Post-Transplant Graft Function Is Associated with Major Cardiovascular Events in Kidney Transplant Recipients: A Multicenter Cohort Study.
1Department of Internal Medicine, Dongguk University Ilsan Hospital, Gyeonggi-do, Korea
2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
3Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea
4Department of Internal Medicine, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Korea
5Department of Surgery, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Korea
6Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea
Meeting: 2017 American Transplant Congress
Abstract number: D133
Keywords: Graft failure, Graft function, Kidney transplantation, Mortality
Session Information
Session Name: Poster Session D: Kidney: Cardiovascular and Metabolic
Session Type: Poster Session
Date: Tuesday, May 2, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
Background: Reduced kidney function is an independent risk factor for cardiovascular disease in the general population. However, the association between post-transplantation graft function and subsequent cardiovascular disease remains uncertain. Therefore, we investigated the outcomes of transplantation in kidney transplant recipients.
Methods: A total of 2,419 kidney transplant recipients in a multicenter cohort were included to evaluate the effects of post-transplant graft function on major adverse cardiovascular events (MACE: cardiac death, nonfatal myocardial infarction, or coronary revascularization), graft failure, and mortality. Recipients were classified into 3 groups according to their estimated glomerular filtration rate (eGFR): group 1 (eGFR ≥ 60 mL/min/1.73 m2, n=1,441), group 2 (30 ≤ eGFR < 60 mL/min/1.73 m2, n=907), and group 3 (eGFR < 30 mL/min/1.73 m2, n=71). Multivariate Cox hazard model was used to explore the association of eGFR with MACE.
Results:Median age was 42 years and 58.8% were male. Median eGFR was 63.6 mL/min/1.73 m2. In 2,419 participants, there were 93 cases of MACE, 214 cases of graft failure, and 76 patient deaths over a median of 6.1 years. The cumulative rates of MACE were higher in the group of lower graft function. In multivariate Cox regression, lower graft function was significantly associated with the occurrence of MACE (hazard ratio 1.5, 95% confidence interval 1.0–2.3, P[thinsp]=[thinsp]0.04) compared to higher graft function.Additionally, cumulative rates of graft failure and mortality were also significantly higher in recipients with lower graft function.
Conclusion:Post-transplant graft function independently correlates with MACE, graft failure, and mortality, suggesting management of graft function may improve the patient and graft survival and cardiac outcome of kidney transplant recipients.
CITATION INFORMATION: Park J, Kim Y, Yang S, Park S, Park S.-K, Han D, Kim Y, Kim Y, Lee J. Post-Transplant Graft Function Is Associated with Major Cardiovascular Events in Kidney Transplant Recipients: A Multicenter Cohort Study. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Park J, Kim Y, Yang S, Park S, Park S-K, Han D, Kim Y, Kim Y, Lee J. Post-Transplant Graft Function Is Associated with Major Cardiovascular Events in Kidney Transplant Recipients: A Multicenter Cohort Study. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/post-transplant-graft-function-is-associated-with-major-cardiovascular-events-in-kidney-transplant-recipients-a-multicenter-cohort-study/. Accessed November 22, 2024.« Back to 2017 American Transplant Congress