ATC Abstracts

American Transplant Congress abstracts

Urine Biomarkers (UBio) Correlate Poorly with Pre-Liver Transplant (LT) Kidney Biopsy Findings and Post-LT Kidney Function.

1Transplant, Mayo Clinic, Jacksonville, FL
2Medicine, Section of Nephrology, Yale University, New Haven, CT
3Medicine, Division of Nephrology, Mayo Clinic, Rochester, MN

Meeting: 2017 American Transplant Congress

Abstract number: D40

Keywords: , ,

Session Information

Session Name: Poster Session D: Diagnostics/Biomarkers Session II

Session Type: Poster Session

Date: Tuesday, May 2, 2017

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall D1

UBio might be valuable in determining the etiology of renal dysfunction in LT candidates.Aim: Correlate UBio with pre-LT kidney biopsy and post-LT kidney function.Methods:78 LT candidates with renal dysfunction (iothalamate GFR<40ml/min or proteinuria>500mg/d) had pre-LT UBio. 28 patients had either pre-LT (n=20) or intra-operative (n=8) kidney biopsy. 58 patients received LT. Serum Cr and 24-hr urine Cr clearance were measured post-LT. UBio were correlated with the % interstitial fibrosis (IF) and % glomerulosclerosis (GS) on kidney biopsy and post-LT renal function.Results: Patients' demographics and biopsy findings are in Table 1

Variable N=78
Median age 61
%Caucasian 92
%Male 53
%HCV 31
%Diabetes Mellitus 41
%Hypertension 61
Median serum Cr 1.8 (0.6,3.3)
Median iGFR 29 (9,127)
Kidney Biopsy findings N=28
Median %IF 5 (0,40)
Median %GS 22 (0,77)

Correlations of UBio with biopsy findings are in Table 2

Urinary biomarker Correlation with %IF P Correlation with %GS P
Neutrophil gelatinase-associated lipocalin (NGAL) n=18 0.4(-0.08,0.7) 0.09 0.09(-0.4,0.5) 0.7
Insulin-like binding protein-7(IGFBP-7)n=9 -0.7(-0.9,-0.2) 0.02 -0.3(-0.8,0.5) 0.5
Tissue injury marker protein-2 (TIMP-2)n=8 -0.1(-0.8,0.6) 0.7 0.8 (0.3,0.9) 0.007
α-1 microglobulin (α-1m)n=9 0.7(-0.03,0.9) 0.06 0.6(-0.2,0.9) 0.1
Interleukin-18 (IL-18)n=23 0.2(-0.5,0.3) 0.4 -0.5(-0.7,-0.05) 0.03
Kidney Injury Marker-1 (KIM-1)n=21 0.003(-0.4,0.4) 0.9 0.3(-0.1,0.7) 0.1

and with the post-LT renal function in Table 3Conclusions: elevated α-1m and low IGFBP-7 may reflect renal fibrosis LT candidates.No consistent pattern of UBio with post-LT renal function was observed.

CITATION INFORMATION: Wadei H, Belcher J, Parikh C, Gonwa T, Mai M, Lieske J. Urine Biomarkers (UBio) Correlate Poorly with Pre-Liver Transplant (LT) Kidney Biopsy Findings and Post-LT Kidney Function. Am J Transplant. 2017;17 (suppl 3).

To cite this abstract in AMA style:

Wadei H, Belcher J, Parikh C, Gonwa T, Mai M, Lieske J. Urine Biomarkers (UBio) Correlate Poorly with Pre-Liver Transplant (LT) Kidney Biopsy Findings and Post-LT Kidney Function. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/urine-biomarkers-ubio-correlate-poorly-with-pre-liver-transplant-lt-kidney-biopsy-findings-and-post-lt-kidney-function/. Accessed November 22, 2024.

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