Objectives: To evaluate the influence of single nucleotide polymorphisms (SNP)of IL10, TNFα, IFNγand IL18 in the incidence of CMV infection in renal transplant recipients. Methods: A retrospective cohort study from a prospective database included 709 patients that received a renal transplant at our center between 2005-2013. We excluded re-transplant, not Caucasian, primary graft failure or death in the early post-transplant. SNP analysis was performed by real-time PCR with Taqman® probes. The patients were stratified according to the higher producing genotype. Results: The incidence of CMV infection and disease was of 37% and 6.4% respectively.The main risk factors are described in tables 1 and 2. There was a significant independent association between SNP -137 G/C of IL18 and CMV infection, where carriers of G allele had a higher risk of CMV infection (OR=2.79; CI 95%: 1.00-7.78; p=0.044). In the subgroup of patients that received prophylaxis for CMV, the main risk factor for infection after discontinuation of Valgancyclovir was being a carrier of G allele (OR=5.10; CI 95%: 1.12-23.20; p=0.035). No patients developed CMV disease within non-carriers.

Conclusions: SNP -137G/C of IL18 can affect the incidence of CMV infection and response towards prophylaxis with Valgancyclovir. The knowledge of these polymorphisms in recipients previous to transplantation and a closer virologicalmonitorization in those patients with a higher risk of CMV infection can aid in the individualization of treatment regimens and lower the rate of infectious complications.

CITATION INFORMATION: Perez-Flores I, Moreno De La Higuera M, Calvo Romero N, Rodriguez Cubillo B, Shabaka A, Calvo Arevalo M, Lopez De La Manzanara V, Sanchez-Fructuoso A. CMV Infection in Renal Transplant Recipients: Incidence and Efficacy of Prophylaxis According to Cytokine Single Nucleotide Polymorphisms. Am J Transplant. 2017;17 (suppl 3).

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