Effect of Angiotensin Converting Enzyme Inhibitor (ACEI) or Angiotensin Receptor Blockade (ARB) Exposure on Intragraft Gene Expression of Kidney Transplant Patients.
1Kidney Transplant, Montefiore Medical Center, Bronx, NY
2Albert Einstein College of Medicine, Bronx, NY
3National University of Ireland Galway University, Galway, Ireland
4Funded by NIH T-32 DK007110, National Institute of Health, Bethesda, MD.
Meeting: 2016 American Transplant Congress
Abstract number: 341
Keywords: Gene expression, Genomics
Session Information
Session Name: Concurrent Session: Metabolic Complications in Kidney Transplantation
Session Type: Concurrent Session
Date: Monday, June 13, 2016
Session Time: 4:30pm-6:00pm
Presentation Time: 4:54pm-5:06pm
Location: Room 312
Objective: Treatment with ACEI or ARB has been shown to have anti-inflammatory effects in animal models but this effect has not been investigated in kidney transplant recipients. We aimed to study the effect of ACEI or ARB treatment on intragraft gene expression profiles of transplant kidney biopsies using microarrays.
Methods: We identified 29 near normal biopsies with chronic sum allograft injury score (ct+ci+cv) ≤ 3 for gene expression profiling comparing 2 groups; Group 1 (n=16), patients with no exposure of ACEI or ARB treatment and Group 2 patients (n=13) with exposure to ACEI or ARB at least 6 months prior to kidney biopsy. Biopsies with a diagnosis of acute or chronic rejection, recurrent or de novo glomerular disease, or polyoma nephropathy were excluded. The gene expression profiles were studied by Affymetrix HuGene 1.0 ST expression arrays.
Results: Both groups had similar demographics characteristics in terms of age, race, sex, type of transplant, previous history of transplantation or acute rejection, panel reactive antibody levels and immunosuppressive treatment. There were no differences in acute and chronic Banff allograft injury scores between the 2 Groups. Intragraft gene expression profiles of ACEI or ARB treated Group 2 biopsies showed decreased gene transcripts of interferon-gamma and rejection-associated transcripts (GRIT) and constitutive macrophage-associated transcripts (CMAT) compared to Group 1 biopsies. There were no statistically significant differences in expression of cytotoxic T cell (CAT), regulatory T cell (TREG), B-cell (BAT), natural killer cell (NKAT), and endothelial cell-associated transcripts (ENDAT) between the 2 Groups.
Conclusions: Our data suggest that exposure to ACEI or ARB was associated with down-regulation of GRIT and CMAT. This anti-inflammatory effect of ACEI or ARB treatment could be an additional benefit in kidney transplant recipients.
| Pathogenesis Based Transcripts | G2 VS G1 (DOWNREGULATED) |
| GRIT | 0.048 |
| CAT | 0.18 |
| TREG | 0.07 |
| BAT | 0.42 |
| NKAT | 0.35 |
| CMAT | 0.048 |
| ENDAT | 0.52 |
CITATION INFORMATION: Suarez-Fuentes C, O Broin P, Bao Y, Akalin E. Effect of Angiotensin Converting Enzyme Inhibitor (ACEI) or Angiotensin Receptor Blockade (ARB) Exposure on Intragraft Gene Expression of Kidney Transplant Patients. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Suarez-Fuentes C, Broin PO, Bao Y, Akalin E. Effect of Angiotensin Converting Enzyme Inhibitor (ACEI) or Angiotensin Receptor Blockade (ARB) Exposure on Intragraft Gene Expression of Kidney Transplant Patients. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/effect-of-angiotensin-converting-enzyme-inhibitor-acei-or-angiotensin-receptor-blockade-arb-exposure-on-intragraft-gene-expression-of-kidney-transplant-patients/. Accessed November 22, 2024.« Back to 2016 American Transplant Congress