Introduction: Major concerns about the utilization of pediatric pancreata are the cumulative islet mass and the increased technical complexity. The primary aim of this study was to investigate the non-inferiority of pediatric donor when compared to adult donor.

Materials and Methods: Analysis was performed from the OPTN database. The study subject was pancreas transplantation from pediatric donor (≤18 years) in the era 2000 to 2015.

Results: In the era selected, 18430 pancreas transplants were performed from 4915 (27.7%) pediatric donors. Differences between the pediatric and the adults donor cohort included: donor BMI (22.2 vs 24.2 p<0.000) and weight (65.0Kg vs. 73.3Kg p<0.000); Amylase value at procurement (72 u/L vs. 63 u/L p<0.000), donor Insulin requirement (1888 (57.8%) vs 5653 (61.2%) p:0.001); recipient BMI (24.5 vs 24.7 p:0.005) and weight (71.4Kg vs 72.1 p:0.004). Results of patient and graft survival by donor type, age groups, weight groups and recipient donor weight ratio are summarized in

The risk of graft loss was associated with younger age (HR 0.98 95% CI 0.97-0.99 p<0.001) and longer length of stay (HR 1 CI 1.00-1.00 p: 0.001).

Conclusion: Pancreata from pediatric donors offers not inferior outcome of their adult counterpart and should be used without hesitation. However the graft (and patient) survival standardized by weight groups clearly shows at 10 years that the cumulative islet mass matters. Keeping a recipient/donor weight ratio <2 could be an easy strategy to optimize the long term results.

CITATION INFORMATION: Spaggiari M, Tzvetanov I, Jeon H, Benedetti E, Oberholzer J. Pancreas Transplantation from Pediatric Donors: A UNOS Registry Analysis. Am J Transplant. 2016;16 (suppl 3).

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