Circulating Immune Complexes of IgA Bound to Beta 2 Glycoprotein I Is a Predictive Marker for Graft Loss in Patients Positive for IgA aB2GPI.

J. Morales, M. Serrano, J. Martínez-Flores, D. Perez, M. Sevilla, O. Cabrera, A. Serrano.

Immunology, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain.

Meeting: 2016 American Transplant Congress

Abstract number: B224

Keywords: Antibodies, Autoimmunity, Graft survival

Session Information

Session Name: Poster Session B: Kidney: Cardiovascular and Metabolic

Session Type: Poster Session

Date: Sunday, June 12, 2016

Session Time: 6:00pm-7:00pm

Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

Pretransplant IgA anti Beta-2-Glycoprotein 1 antibodies (IgA aB2GPI) is a risk marker for early kidney graft lost, mainly by thrombosis. About 30% of patients are IgA aB2GPI positive in pretransplant situation. However, only 10% of them lose the graft, needing new biomarkers to predict graft loss. Recently we describe immune complexes of IgA bounded to B2GPI (B2A-CIC) in patients IgA aB2GPI positive and clinical criteria of Antiphospholipid Syndrome

Our aim is to evaluate B2A-CIC in patients positive por IgA aB2GPI who receive a kidney transplant

25 positive IgA aB2GPI patients without early graft loss (Group-1) and 25 positive IgA aB2GPI patients with early graft loss in the firsts 6 months (Group-2) during 2009 to 2012 were analyzed in the pretransplant sample.

Group-1 IgA aB2GPI mean levels was 68.5± 12.3 UI and 71.4± 10.5 UI for Group 2 (p>0.05). B2A-CIC mean levels was 14.1 ± 2.2AU, significantly lower than Group-2 mean levels, 27.1 ± 3.8AU (p = 0.001). Percentage of positive B2A-CIC patients in Group-1 was 20.0% (5/25) (> 21.0 AU) and Group-2 presented a positivity of 80.0% (20/25) (P <0.001).

The presence of B2A-CIC is a predictive marker of graft loss. This makes possible the localization the population actually at risk of graft loss and improve the management and treatment of patients trying to avoid graft loss.

CITATION INFORMATION: Morales J, Serrano M, Martínez-Flores J, Perez D, Sevilla M, Cabrera O, Serrano A. Circulating Immune Complexes of IgA Bound to Beta 2 Glycoprotein I Is a Predictive Marker for Graft Loss in Patients Positive for IgA aB2GPI. Am J Transplant. 2016;16 (suppl 3).

To cite this abstract in AMA style:

Morales J, Serrano M, Martínez-Flores J, Perez D, Sevilla M, Cabrera O, Serrano A. Circulating Immune Complexes of IgA Bound to Beta 2 Glycoprotein I Is a Predictive Marker for Graft Loss in Patients Positive for IgA aB2GPI. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/circulating-immune-complexes-of-iga-bound-to-beta-2-glycoprotein-i-is-a-predictive-marker-for-graft-loss-in-patients-positive-for-iga-ab2gpi/. Accessed November 22, 2024.

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