Objectives: The aims of this study were to evaluate the prognostic value of preoperative serum gamma-glutamyltranspeptidase (γ-GGT) in patients with hepatocellular carcinoma (HCC) underwent liver transplantation (LT) and the relationship between γ-GGT and tumor-related characteristics.

Methods: We retrospectively analyzed the clinical data of 101 HCC patients after LT. The optimal cutoff value of γ-GGT was determined by the receiver operating characteristic (ROC) curve. The disease-free survival (DFS) and overall survival (OS) curves were plotted using Kaplan-Meier method and compared using log-rank test. The correlation of γ-GGT with tumor-related characteristics was also analyzed.

Results: The optimal cutoff value of γ-GGT was 128U/L, with the sensitivity and specificity of 60.0% and 72.5%, respectively. Elevated preoperative serum γ-GGT was significantly associated with high alpha-fetoprotein (AFP), large tumor size, macro- and micro-vascular invasion. The 1-, 3-, 5-year DFS (49.4%, 33.8%, 19.7% VS 80.7%, 68.3%, 63.8%, P < 0.001) and OS rates (68.2%, 36.4%, 25.7% VS 94.7%, 77.1%, 67.7%, P < 0.001) of HCC patients in the γ-GGT > 128U/L group were poorer than those in the γ-GGT ≤ 128U/L group[figure1]. Stratification analysis founded that γ-GGT indicated a greater predictive value for DFS and OS in HCC patients without Milan criteria and no macro-vascular invasion .

Conclusions: Elevated preoperative serum γ-GGT was significantly associated with advanced tumor stage and aggressive tumor behaviors, and it can be considered as a prognostic factor for HCC patients after LT, especially for patients without Milan criteria and no macro-vascular invasion.

CITATION INFORMATION: Fu S, Zhao Q, Chen M, Wu L, Ren Q, Ji F, Guo Z, He X. Predictive Value of Preoperation Serum Gamma-Glutamyltranspeptidase for Hepatocellular Carcinoma Prognosis After Liver Transplantation. Am J Transplant. 2016;16 (suppl 3).

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