2016 American Transplant Congress
Impact of Mixed Xenogeneic Porcine Hematopoietic Chimerism on Human NK Cell Recognition in a Humanized Mouse Model.
Xenotransplantation is a potential solution for the shortage of organs for transplantation. However, potent xenograft rejection responses present a formidable barrier. Mixed xenogeneic hematopoietic chimerism…2016 American Transplant Congress
Long Term Heterotopic Cardiac Xenograft Survival from Donor Pigs with Six Gene Modifications.
1CSRP, NHLBI/NIH, Bethesda, MD; 2DVR / RS, NIH, Bethesda, MD; 3Revivicor, Inc, Blacksburgh, VA.
Introduction: We have recently reported pig xenograft survival of more than 2.5 years in a heterotopic cardiac xenograft model. Some of the animals exhibited local…2016 American Transplant Congress
Human Leukocyte Antigen-E Expression on Porcine GalTKO.hCD46 Cells Improves Ex-Vivo Xenograft Survival and Attenuates Injury.
1University of Maryland School of Medicine, Baltimore, MD; 2Revivicor, Inc, Blacksburg, VA.
Purpose:Lung xenografts are subject to injury mechanisms associated with the sequestration of human cells, including natural killer (NK) cells. To control NK cell associated injury,…2016 American Transplant Congress
Long-Term Islet Xenograft Survival Requires Effective Control of Early Xenogeneic IL-17 Response and Late Xenogeneic IFN-γ Response.
Introduction: Tolerance induction for xenogeneic islet transplant remains a challenge. We have previously shown that peri-transplant infusion of donor cells treated with 1-ethyl-3-(3'-dimethylaminopropyl)-carbodiimide (ECDI) is…2016 American Transplant Congress
Successful Human-to-NonHuman Primate Pancreatic Islet Intraportal Xenotransplantation Using a Human Allo-Based Immunosuppression Regimen and Its Potential Pre-Clinical Application.
Intraportal pancreatic islet cell transplantation is a successful treatment for type-1 diabetes (T1DM) in humans. Unfortunately, the lack of donor pancreatic organs is a major…2016 American Transplant Congress
Multiplex Profiling of Plasma Proteins After Xenogenic Lung Exposure.
Background: Porcine lungs exhibit injury by human blood and are only partially protected in GalTKO organs with additional human membrane cofactor protein (hCD46). Residual injury…2016 American Transplant Congress
Human PDL1+ SLA-DR– Swine Vascular Endothelial Cells Suppress Pig-Human PBMC Xeno-MLR(Mixed Lymphocyte Reaction) by Inducing Human Regulatory IL-10+Tr1(Type 1 Regulatory T Cells) Subset for Suppression of Xenogeneic Reactions.
Type 1 regulatory T cells(Tr1) are active in transplantation tolerance. The Tr1 cells are inducible in our lab from human CD4 T cells (hCD4 T)…2016 American Transplant Congress
Porcine Islets Engineered with SA-FasL Protein Induces Robust Tolerance in Mice through CD4+CD25+FoxP3+ Treg Cells.
Introduction: We have shown that porcine islets engineered to transiently display SA-FasL protein on their surface establish tolerance in mice following transplantation under the kidney…2016 American Transplant Congress
An Improved Flow Cytometry Based Platelet Counting in Xeno Perfusion Models.
Aim: Human or baboon platelet sequestration and activation occurs during pig organ xenograft perfusion; its mechanism remains poorly understood. In the context of a regimen…2016 American Transplant Congress
aPC Pretreatment of hEPCR-Expressing PAECs Attenuates Endothelial Cell Damage and Thrombosis.
IntroductionActivated Protein C (aPC), acting primarily through the human endothelial protein C receptor (hEPCR), mediates anti-thrombotic and anti-inflammatory cytoprotective effects in humans. We hypothesized that…
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