2022 American Transplant Congress
Protective Immunity Against a Murine Epstein-Barr Virus Homolog is Preserved During CD11b-CD154 Blockade
Emory University Transplant Center, Emory University, Atlanta, GA
*Purpose: CD154 pathway antagonism has shown to be a promising target for inducing long-time graft survival, in some cases showing efficacy that is superior to…2022 American Transplant Congress
Fibroblastic Reticular Cell Subset Transcriptional Reprogramming Differs in Response to Immunity versus Tolerance
1UMB, Baltimore, MD, 2Harvard University, Boston, MD
*Purpose: Lymph node (LN) fibroblastic reticular cells (FRCs) are central contributors to the LN niche. We hypothesized that FRC subsets reactive to immunity versus tolerance…2022 American Transplant Congress
Contributions of Allogenicity and Antigen Presentation to Regulatory B Cell Suppression
Center for Transplantation Sciences, Boston, MA
*Purpose: We previously generated in vitro Toll-like receptor (TLR)-activated B cells became regulatory B cells (Bregs) that suppress T cell proliferation and promote allograft tolerance.…2022 American Transplant Congress
Rhesus-Primatized Mouse Model Generated Using Transgenic Immunodeficient Mice
1Surgery, University of Wisconsin, Madison, WI, 2University of Wisconsin, Madison, WI
*Purpose: To develop a translational primatized mouse model, akin to humanized mice, that allows for high-throughput in vivo experimentation to augment non-human primate pre-clinical studies.*Methods:…2022 American Transplant Congress
Immunomodulatory Effects of Probiotic Bifidobacterium Bifidum with Tacrolimus and Sirolimus in Mouse Skin Graft Model
*Purpose: Accumulating evidence suggests that gut microbiota actively crosstalks with the host immune system, and alterations of gut microbiota may exert immune regulatory effects. We…2022 American Transplant Congress
Donor Kidney-Resident Passenger Macrophages Promote CCL8-CCR8 Mediated Early Allograft Inflammation
*Purpose: Early intragraft infiltration of monocytes and macrophages has been associated with acute and chronic allograft rejections. Nevertheless, underlying mechanism remained poorly understood. In the…2022 American Transplant Congress
A Novel Method for Ex Vivo Stimulation of Mesenchymal Stem Cells via Invariant Natural Killer T Cell Activation with ɑ-galactosylceramide
*Purpose: Mesenchymal stem cells (MSCs) typically exhibit unique regenerative and immunomodulatory properties when exposed to proinflammatory cytokines. Invariant natural killer T (iNKT) cells are known…2022 American Transplant Congress
The Role of LAG3 in Antibody Responses to Kidney Transplantation
*Purpose: The functions of coinhibitory receptor lymphocyte activation gene-3 (LAG3) in T cells are well studied, however its role in humoral immune responses remains poorly…2022 American Transplant Congress
Absence of DAP12 Expression by Donor Liver-Derived Dendritic Cells Enhances Their Contact with T Cells in Host Secondary Lymphoid Tissue: Implications for Abrogation of MHC-mismatched Liver Transplant Tolerance in Mice
University of Pittsburgh, Pittsburgh, PA
*Purpose: Multiphoton intravital microscopy is a high-resolution, real-time, fluorescence imaging technique that enables study of interactions between cells in their native, 3-dimensional environment including organ…2021 American Transplant Congress
Re-Transplantation of Mouse Kidney Grafts to Study Local Immune Responses
Starzl Transplantation Institution, Pittsburgh, PA
*Purpose: Mouse kidney transplantation has been widely used to study the immune response to allogeneic grafts. This response includes a circulating systemic compartment and a…
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