2019 American Transplant Congress
Xenorejection of Porcine Islets in Humanized Mice is Dominated by a Human Th17 Cytokine Immune Response
*Purpose: We have previously shown that interleukin(IL)-17 producing CD4 T cells (Th17 response) dominate in the early anti-donor immune responses of a pig-to-mouse xenogeneic model…2019 American Transplant Congress
Pancreatic Extracellular Matrix Improves Human Islet Culture and Function In Vitro
Virginia Commonwealth University, Richmond, VA
*Purpose: Islet transplantation is a thriving therapy for patients with Chronic Pancreatitis and Type-1 Diabetes. Within the pancreas, the islets are surrounded by Extracellular Matrix…2019 American Transplant Congress
Improvement of the Outcome of Clinical Islet Transplantation Depending on the Era in Japan
*Purpose: Islet transplantation (ITX) is an ideal treatment for type 1 diabetic patients. In this paper, we compared the outcome of ITX depending on Era…2019 American Transplant Congress
Human Mesenchymal Stem Cells Inhibits Hypoxia-Induced Islets Apoptosis via Regulation of Autophagy
The Third Xiang Ya Hospital,Central South University, ChangSha, China
*Purpose: Xenotransplantation of porcine islets has been an emerging and effective option for clinicians to treat type 1 diabetes recently. Comparing with other damage, hypoxic…2019 American Transplant Congress
Microparticle Delivery to Lymph Nodes Induces Specific Suppression to Prolong Islet Survival
1Surgery, U. Maryland, Baltimore, MD, 2U.Maryland, Baltimore, MD, 3U. Maryland, College Park, MD
*Purpose: Microparticles (MP) loaded with peptide antigen plus other immune signals and delivered directly into lymph nodes (LN) can result in either proinflammatory or antiinflammatory…2019 American Transplant Congress
Exosomes Carry Stress and Damage Specific miRNAs during Peritransplant Period in TPIAT
*Purpose: Innate inflammation and hypoxia during peritransplant period significantly affect survival of islet grafts. Markers that can identify stress and/or damage during this early period…2019 American Transplant Congress
CD46 Transgene Modification and Thrombosis in Neonatal Porcine Islet Xenotransplantation
Surgery, Duke University, Durham, NC
*Purpose: Vascular thrombosis activation is an important cause for early xeno-islet loss. To better understand the thrombosis process in islet xenotransplantation and the effect of…2019 American Transplant Congress
Insulin Treatment in Pancreas Donors on the Intensive Care is a Marker of Beta Cell Death as Evidenced by microRNA Data
University of Manchester, Manchester, United Kingdom
*Purpose: We showed in prior studies that donor insulin use on intensive care predicts early beta cell dysfunction in islet and solid pancreas transplantation. We…2019 American Transplant Congress
microRNA-375 Provides an Objective Measure of Pancreas Quality in Organ Donors
*Purpose: Donor pancreatic beta cells are at high risk from apoptosis. Objective methods for assessing the quality of donor pancreases for transplantation are limited. We…2019 American Transplant Congress
Using a Massive Open Online Course on Clinical Kidney, Prancreas and Islet Transplantion in Different Settings of Transplant Education
*Purpose: In 2016 our center launched a Massive Open Online Course (MOOC) on Kidney, Pancreas and Islet Transplantation. As opposed to on-campus education, this course…
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