2019 American Transplant Congress
Bespoke Immunosuppression: Prolonging Transplant Survival through Enhanced T-cell Activation Induced Cell Death
*Purpose: We aim to develop donor-specific immunosuppression by inhibiting T-cell cellular FLICE like inhibitory protein (c-FLIP). Our current work focuses on clinically relevant pharmacological inhibitors…2019 American Transplant Congress
Apoptosis during Cold Ischemia and Rewarming Involves a Caspase Independent Pathway
*Purpose: We have previously shown that hibernating ground squirrels (GS) tolerate core body temperatures of 4°C for several days with a heart rate that is…2019 American Transplant Congress
Eupatilin Ameliorates Tacrolimus Induced Nephrotoxicity via Inhibiting Apoptosis
Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea, Republic of
*Purpose: Tacrolimus (FK506) is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and…2019 American Transplant Congress
Role of NF-kB in Release of Isletokines via Exosomes in Response to Islet Stress
*Purpose: Human islets are exposed to a range of inflammatory stimuli upon transplantation that leads to poor graft survival. Identifying the various signaling events may…2019 American Transplant Congress
Cyclo (his-pro) Protects Against Gentamicin Induced Cell Apoptosis And Cisplatin Induced Acute Kidney Injury Through Inhibiting P53 Mediated Apoptotic Pathway.
*Purpose: Cyclo(His-Pro) (CHP) is an endogenous cyclic dipeptide that exerts cellular protective effects against anti-oxdative damages. However, the role and mechanisms for CHP in preventing…2019 American Transplant Congress
FcγRIIB is a Novel CD8+ Effector T Cell Intrinsic Regulatory Pathway That Correlates with Freedom from Rejection in Renal Transplant Patients
*Purpose: To understand the functional role and clinical relevance of FcγRIIB on CD8+ T cells in transplantation.*Methods: See results*Results: FcγRIIB is the sole inhibitory Fcγ…2019 American Transplant Congress
Bcl-2/Bcl-xL Inhibition by Navitoclax vs. Bcl-2 Alone Inhibition by Venetoclax for Induction of Mixed Chimerism in Non-Human Primates
*Purpose: We recently demonstrated that a specific Bcl-2 inhibitor, Venetoclax, can promote mixed chimerism and renal allograft tolerance in non-human primates (NHPs) with reduced myelosuppressive…2019 American Transplant Congress
NQO-1 Attenuates Renal Ischemia-Reperfusion Injury in Mice
*Purpose: Ischemia-reperfusion (I-R)-induced reactive oxygen species (ROS) are thought to be a major factor in the development of acute renal injury by promoting the initial…2019 American Transplant Congress
Sigma-1 Receptor Agonists Are Renoprotective in a Rat Model of Kidney Transplantation
*Purpose: Kidney transplantation is associated with better quality of life and reduced costs compared to dialysis, but the shortage in donor organs is a limiting…2019 American Transplant Congress
Predominant Role of Microvascular over Tubular Injury as Driver of Progressive Renal Damage and Fibrosis Post Ischemia Reperfusion Injury
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for allograft dysfunction and chronic renal failure. Although tubular epithelial cells (TEC) are considered the main…
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