2015 American Transplant Congress
Innate Immune Memory to Allogeneic Non-Self
Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
A hallmark of adaptive immunity is the generation of long-lived, antigen-specific memory T, B, and NK lymphocytes that mount strong anamnestic (recall) responses to previously…2015 American Transplant Congress
Histologic Patterns of C4d Associated With Acute Antibody Mediated Rejection of the Lung Allograft
Pathology, UT Southwestern Medical Center, Dallas, TX.
The diagnosis of antibody mediated rejection (AMR) of the lung allograft still represents a diagnostic challenge for pathologist and transplant physicians alike. The morphologic and…2015 American Transplant Congress
Host NK Cell Allorecognition of Passenger Donor Lymphocytes Within Allografts Is Essential for Preventing Augmentation of Recipient Adaptive Alloimmunity
Department of Surgery, University of Cambridge, Cambridge, United Kingdom.
Background:Memory T cells are now appreciated to reside in peripheral non-lymphoid tissue, but how their presence within solid organ allografts impacts upon transplant outcomes is…2015 American Transplant Congress
Microchimerism-Tolerance Missing Link: Exosome Acquisition by Host Dendritic Cells
Surgery, University of Wisconsin, Madison, WI.
Background: widespread maternal microchimerism (MMc) in mice is associated with development of immune regulation, which can be used to predict transplantation tolerance. We recently showed…2015 American Transplant Congress
Presence of Donor Leukocytes and Donor MHC-Cross-Dressed Recipient Cells and Its Relationship to Direct T Cell Alloresponses After Allotransplantation
We have studied the kinetics of donor cell trafficking from the graft to recipient's lymphoid organs and its correlation to the direct T cell alloresponse…2015 American Transplant Congress
IgM+ Antigen Binding B Cells in Peripheral Blood Regulate IFNγ Production in Response to HLA Proteins
Chronic antibody mediated rejection (CAMR) is a major cause of graft loss in renal transplant recipients. Previous work utilising an IFNγ ELISPOT assay revealed two…
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