Date: Saturday, June 11, 2016
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Halls C&D
Background. A high incidence of delayed graft function (DGF), after deceased donor kidney transplantation, occurs in Brazil and the reasons for such finding have not been adequately studied.
Methods. We performed a retrospective single center cohort study including 517 deceased donor kidney transplant recipients. Risk factors for DGF were analyzed and correlated with graft outcomes. A multivariable analysis (Poisson regression) was used to identify independent risk factors and patient and graft survival were assessed using Kaplan-Meier curves.
Results. The incidence of DGF was 65.6% (339 cases). In the final multivariate analysis model DGF is significantly associated with donor final serum creatinine, donor age, cold ischemia time, use of antibody induction therapy and diabetes mellitus. The relative risks and 95% confidence intervals were: donor final serum creatinine: 1.088 (1.018 – 1.162); donor age: 1.007 (1.002 – 1.012), cold ischemia time: 1.020 (1.006 – 1.034), use of antibody induction therapy: 1.787 (1.103 – 2.896) and diabetes mellitus as cause o recipient kidney disease: 1.162 (1.002 – 1.347). The occurrence of DGF was also associated with longer length of hospital stay (31.7 ± 20.9 versus 18.5 ± 12.9 days; P = 0.01), higher incidence of acute treated (35.9 versus 20.0%; P < 0.01) and BANFF 1A or higher acute rejection (24.5 versus 14.7%; P = 0.017), lower graft function at 3, 6 and 12 months after transplantation and worse death censored graft survival at 1 year (94.0% versus 96.6%; P < 0.038) and at 5 years (84,6 versus 95%, p=0,038). No differences were found in patient survival.
Conclusion. In the present cohort DGF was associated with higher donor age, final serum creatinine, cold ischemia time, diabetes mellitus and need for antibody induction therapy. Most importantly, DGF was associated with worse outcomes in terms of graft function and survival.
CITATION INFORMATION: Ribeiro A, Helfer M, Costa O, Viccari A, Manfro R. Incidence, Risk Factors, and Outcomes of Delayed Graft Function in Deceased Donor Kidney Transplantation in a Brazilian Center. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Ribeiro A, Helfer M, Costa O, Viccari A, Manfro R. Incidence, Risk Factors, and Outcomes of Delayed Graft Function in Deceased Donor Kidney Transplantation in a Brazilian Center. [abstract]. Am J Transplant. 2016; 16 (suppl 3). http://atcmeetingabstracts.com/abstract/incidence-risk-factors-and-outcomes-of-delayed-graft-function-in-deceased-donor-kidney-transplantation-in-a-brazilian-center/. Accessed September 21, 2017.
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