Articles tagged "Warm ischemia"

2017 American Transplant Congress
Longer Anastomotic Time Leads to Delayed Graft Function.
M. Heer,^1,2 P. Trevillian,^1,2,3 A. Hibberd.^1,2,3
¹Newcastle Transplant Unit, John Hunter Hospital, Newcastle, NSW, Australia; ²Newcastle University, Newcastle, NSW, Australia; ³Hunter Transplant Research Foundation, Hunter Medical Research Institute, Newcastle, NSW, Australia
Background: Delayed graft function (DGF) occurs at variable rates in renal transplant recipients. It can be deleterious to renal allograft in long term. Various factors…
2017 American Transplant Congress
Lactate Level Immediate Post-Liver Transplantation Is a Predictor of Early Allograft Dysfunction.
K. Takahashi,^1,2 S. Nagai,¹ M. Safwan,¹ K. Putchakayala,¹ K. Collins,¹ M. Rizzari,¹ A. Yoshida,¹ M. Abouljoud,¹ S.-M. Jafri.³
¹Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; ²Surgery, University of Tsukuba, Tsukuba, Ibaraki, Japan; ³Gastroenterology, Henry Ford Hospital, Detroit, MI
Background; Early allograft dysfunction (EAD) after liver transplantation (LT) is defined as a peak values of aminotransferase >2000 IU/mL during the first week or an…
2017 American Transplant Congress
Controlled Donation After Circulatory Death (cDCD) Donors May Become Similar to Brain Death Donors (DBD).
C. Antoine,¹ M. Videcoq,² B. Riou,³ D. Dorez,⁴ G. Cheisson,⁵ L. Martin-Lefèvre,⁶ L. Durand,¹ E. Savoye,¹ G. Karam,² B. Barrou.³
¹Agence de la Biomedecine, Saint Denis La Plaine, France; ²University Hospital, Nantes, France; ³University Hospital La Pitie, Paris, France; ⁴Hospital, Annecy, France; ⁵University Hospital, Kremlin Bicetre, France; ⁶Hospital, La Roche Sur Yon, France
Since 2014 in France, we started a cDCD program characterized by the introduction of normothermia regional perfusion (nRP) and selection criteria as donor age ≤65…
2016 American Transplant Congress
Comparison of Three Approaches for Laparoscopic Donor Nephrectomy: Transvaginal, Transumbilical Single Site and Retroperitoneal.
M. Miura, H. Higashiyama.
Department of Urology and Renal Transplantation Surgery, Sapporo Hokuyu Hospital, Sapporo, Japan.
Objectives: Reduction of burdens to live kidney donors are important. The aim of this study was to compare the surgical outcomes of 3 approaches we…
2016 American Transplant Congress
HO-1/SIRT1/p53 Axis Regulates Macrophage Activation and Attenuates Liver Ischemia-Reperfusion Injury in Mice.
K. Nakamura,¹ M. Zhang,² B. Ke,¹ S. Kageyama,¹ R. Busuttil,¹ J. Araujo,² J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, University of California-Los Angeles, Los Angeles, CA; ²Medicine, Division of Cardiology, University of California-Los Angeles, Los Angeles, CA.
Background/Aim: The mechanism by which macrophage heme oxygenase-1 (HO-1)-Sirtuin1 (SIRT1) signaling promotes resistance against inflammation response in liver ischemia-reperfusion injury (IRI) remains elusive. As tumor…
2016 American Transplant Congress
Protective Effects of Nrf2 Over-Activation in Myeloid Cells During Hepatic Ischemia Reperfusion Correlates with Stat3 Signaling in Hepatocytes.
C. Harberg,¹ L.-Y. Lee,¹ S. Werner,² D. Johnson,³ J. Johnson,³ D. Foley.¹
¹Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI; ²Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland; ³Pharmaceutical Sciences, University of Wisconsin School of Pharmacy, Madison, WI.
Ischemia-reperfusion injury (IRI) is a consequence of liver resection and liver transplantation. The Nrf2-antioxidant response element pathway is a key mediator of cellular defense against…
2016 American Transplant Congress
Reciprocal Effects of HDAC1 and HDAC2 Deletion on Renal Cold Ischemia Survival and Nuclear Co-Repressor Complex Expression.
D. Aufhauser Jr,¹ D. Murken,¹ Z. Wang,¹ A. Samanta,² G. Ge,¹ T. Bhatti,³ W. Hancock,^2,3 M. Levine.¹
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ³Pathology and Laboratory Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Class I histone/protein deacetylases (HDACs) 1 and 2 bear >85% protein sequence homology and conventionally are thought to have similar function via occupancy in…
2016 American Transplant Congress
Short, Cool and Well Oxygenated – HOPE for DCD Kidneys.
P. Kron, A. Schlegel, O. de Rougemont, C. Oberkofler, P.-A. Clavien, P. Dutkowski.
University Hospital, Zurich, Switzerland.
Background Organs from donors after cardiac death (DCD) suffer from severe loss of function requiring development of innovative methods of preservation. A novel perfusion approach,…
2016 American Transplant Congress
Hydrogen Sulfide Supplementation Helps Mitigate Effects of Ischemia Reperfusion Injury in a Murine Model of Donation After Cardiac Death Renal Transplantation.
J. Grewal,¹ I. Lobb,¹ M. Saha,² J. Jiang,² A. Haig,¹ A. Sener.^1,2
¹Microbiology & Immunology, University of Western Ontario, London, Canada; ²Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, Canada.
Donation after cardiac death(DCD) renal grafts experience a combination of prolonged warm and cold ischemia leading to greater ischemia reperfusion injury(IRI) that results in higher…
2016 American Transplant Congress
Predictors of Urologic Complications After Pediatric En-Bloc Donor Kidney Transplantation.
S. Kabagambe,¹ A. De Mattos,² R. Perez,¹ C. Santhanakrishnan,¹ J. Sageshima,¹ C. Troppmann,¹ J. McVicar.¹
¹Surgery, University of California-Davis, Sacramento, CA; ²Transplant Nephrology, University of California-Davis, Sacramento, CA.
Pediatric en-bloc kidney transplant (PEBKT) has expanded the donor pool. Association of donor characteristics and urologic complications is not well described. The objective of this…