Articles tagged "Warm ischemia"

2017 American Transplant Congress
Longer Anastomotic Time Leads to Delayed Graft Function.
M. Heer,^1,2 P. Trevillian,^1,2,3 A. Hibberd.^1,2,3
¹Newcastle Transplant Unit, John Hunter Hospital, Newcastle, NSW, Australia; ²Newcastle University, Newcastle, NSW, Australia; ³Hunter Transplant Research Foundation, Hunter Medical Research Institute, Newcastle, NSW, Australia
Background: Delayed graft function (DGF) occurs at variable rates in renal transplant recipients. It can be deleterious to renal allograft in long term. Various factors…
2017 American Transplant Congress
Lactate Level Immediate Post-Liver Transplantation Is a Predictor of Early Allograft Dysfunction.
K. Takahashi,^1,2 S. Nagai,¹ M. Safwan,¹ K. Putchakayala,¹ K. Collins,¹ M. Rizzari,¹ A. Yoshida,¹ M. Abouljoud,¹ S.-M. Jafri.³
¹Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; ²Surgery, University of Tsukuba, Tsukuba, Ibaraki, Japan; ³Gastroenterology, Henry Ford Hospital, Detroit, MI
Background; Early allograft dysfunction (EAD) after liver transplantation (LT) is defined as a peak values of aminotransferase >2000 IU/mL during the first week or an…
2017 American Transplant Congress
Controlled Donation After Circulatory Death (cDCD) Donors May Become Similar to Brain Death Donors (DBD).
C. Antoine,¹ M. Videcoq,² B. Riou,³ D. Dorez,⁴ G. Cheisson,⁵ L. Martin-Lefèvre,⁶ L. Durand,¹ E. Savoye,¹ G. Karam,² B. Barrou.³
¹Agence de la Biomedecine, Saint Denis La Plaine, France; ²University Hospital, Nantes, France; ³University Hospital La Pitie, Paris, France; ⁴Hospital, Annecy, France; ⁵University Hospital, Kremlin Bicetre, France; ⁶Hospital, La Roche Sur Yon, France
Since 2014 in France, we started a cDCD program characterized by the introduction of normothermia regional perfusion (nRP) and selection criteria as donor age ≤65…
2017 American Transplant Congress
Warm Ischemic Time as an Additive Predictor of Graft Survival in KDPI/KDRI Era of Kidneys from Donors After Cardiac Death: A Single-Center Experience Over Three Decades.
M. Kusaka,¹ Y. Kubota,¹ H. Takahashi,² H. Sasaki,¹ M. Takenaka,¹ N. Fukami,¹ T. Kenmochi,³ R. Shiroki,¹ K. Hoshinaga.¹
¹Urology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; ²Division of Medical Statistics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; ³Organ Transplant Surgery, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
It is important to predict the outcome of grafts prior to kidney transplantation and establish an appropriate allocation system, particularly to consider expanded criteria donors…
2017 American Transplant Congress
Beneficial Effects of Hydrogen Sulfide (H2S) on Renal Ischemia-Reperfusion Injury (IRI) in CLAWN Miniature Swine.
Y. Ariyoshi, M. Sekijima, H. Sahara, T. Murokawa, A. Shimizu, K. Yamada.
Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan
Objective: The prevention of IRI is important for both early and long-term graft function, especially when using extended-criteria or donation after cardiac donors. H2S has…
2017 American Transplant Congress
Dendritic Cell Expression of Rictor (mTORC2), but Not Raptor (mTORC1), Protects Against Renal Ischemia-Reperfusion Injury.
H. Dai,^1,3 N. Rogers,^1,2 A. Watson,¹ D. Fantus,¹ A. Thomson.¹
¹Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; ²Westmead Institute for Medical Research, Sydney, Australia; ³Urologic Organ Transplantation Department, the Second Xiangya Hospital, Central South University, Changsha, China
Background: Dendritic cells (DC) are critical initiators of innate immunity in the kidney and orchestrate inflammation subsequent to ischemia-reperfusion injury (IRI). The mechanistic target of…
2017 American Transplant Congress
Objective Assessment of Graft Metabolism and Function During Ex Vivo Liver Perfusion.
J. Echeverri,¹ S. Cleland,² M. Kaths,¹ I. Linares,¹ R. Roizales,¹ N. Goldaracena,¹ D. Kollmann,¹ M. Hamar,¹ P. Urbanellis,¹ S. Ganesh,¹ O. Adeyi,³ D. Grant,¹ N. Selzner,⁴ M. Wasowicz,² M. Selzner.¹
¹Multi-Organ Transplant Program, Department of Surgery, University of Toronto - Toronto General Hospital, Toronto, ON, Canada; ²Multi-Organ Transplant Program, Department of Anesthesia, University of Toronto - Toronto General Hospital, Toronto, ON, Canada; ³Multi-Organ Transplant Program, Department of Pathology, University of Toronto - Toronto General Hospital, Toronto, ON, Canada; ⁴Multi-Organ Transplant Program, Department of Medicine, University of Toronto - Toronto General Hospital, Toronto, ON, Canada
During EVLP no objective perfusion parameters have been found to predict outcome after transplantation.Methods: Livers with 4grades of injury were perfused for 4 hours and…
2017 American Transplant Congress
Ex-Situ Extended Limb Preservation: A Protocol for Porcine Limb Perfusion.
E. Dalla Pozza,¹ E. Duraes,¹ M. Madajka,¹ R. Frautschi,¹ K. Cho,¹ N. Dawlagala,¹ V. Fahradyan,¹ H. Shah,¹ C. Cakmakoglu,¹ C. Quintini,² F. Papay,¹ A. Rampazzo,¹ B. Bassiri Gharb.¹
¹Plastic Surgery, Cleveland Clinic, Cleveland, OH; ²General Surgery, Cleveland Clinic, Cleveland, OH
Background: Ischemia and reperfusion injury remains a significant limiting factor for the success of vascularized composite allotransplantation. Compared to the cold storage of the procured…
2017 American Transplant Congress
Improved Preservation During Normothermic Ex-Vivo Liver Perfusion with Delta Opioid Agonist (D-Ala2, D-Leu5) Enkephalin (DADLE).
E. Beal,¹ J. Kim,¹ D. Hayes Jr.,² K. Washburn,¹ B. Whitson,¹ S. Black.¹
¹Department of Surgery, Division of Transplant, The Ohio State University Wexner Medical Center, Columbus, OH; ²Departments of Pediatrics and Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background: The metabolic demand of donor livers during prolonged normothermic ex-vivo perfusion with its associated oxygen stress is a challenge. Delta opioid agonist (D-Ala2, D-Leu5)…
2017 American Transplant Congress
Donor Warm Ischemic Time >80min Is an Important Predictor of Kidney Graft Survival from Donors After Cardiac Death.
J. Chen,¹ D. Mikhail,² H. Sharma,³ A. Hijazi,¹ D. Nap,¹ L. Stitt,⁴ J. Jevnikar,⁵ M. Cooper,⁶ P. Luke,² A. Sener.²
¹Schulich School of Medicine & Dentistry, London, Canada; ²Urology, Western University, London, Canada; ³General Surgery, Western University, London, Canada; ⁴LW Stitt Statistical Services, London, Canada; ⁵Engineering, Ryerson University, Toronto, Canada; ⁶Georgetown University, Washington
We analyzed UNOS data to determine how donor warm ischemic time (WIT), donor BMI, donor hypertension (dHTN), cold ischemic time (CIT), and vasopressin use in…