Articles tagged "Warm ischemia"

2017 American Transplant Congress
Improved Preservation During Normothermic Ex-Vivo Liver Perfusion with Delta Opioid Agonist (D-Ala2, D-Leu5) Enkephalin (DADLE).
E. Beal,¹ J. Kim,¹ D. Hayes Jr.,² K. Washburn,¹ B. Whitson,¹ S. Black.¹
¹Department of Surgery, Division of Transplant, The Ohio State University Wexner Medical Center, Columbus, OH; ²Departments of Pediatrics and Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background: The metabolic demand of donor livers during prolonged normothermic ex-vivo perfusion with its associated oxygen stress is a challenge. Delta opioid agonist (D-Ala2, D-Leu5)…
2017 American Transplant Congress
Donor Warm Ischemic Time >80min Is an Important Predictor of Kidney Graft Survival from Donors After Cardiac Death.
J. Chen,¹ D. Mikhail,² H. Sharma,³ A. Hijazi,¹ D. Nap,¹ L. Stitt,⁴ J. Jevnikar,⁵ M. Cooper,⁶ P. Luke,² A. Sener.²
¹Schulich School of Medicine & Dentistry, London, Canada; ²Urology, Western University, London, Canada; ³General Surgery, Western University, London, Canada; ⁴LW Stitt Statistical Services, London, Canada; ⁵Engineering, Ryerson University, Toronto, Canada; ⁶Georgetown University, Washington
We analyzed UNOS data to determine how donor warm ischemic time (WIT), donor BMI, donor hypertension (dHTN), cold ischemic time (CIT), and vasopressin use in…
2017 American Transplant Congress
Robotic Kidney Transplantation: Bakirkoy Experience.
S. Sahin,¹ V. Tugcu,¹ A. Yavuzsan,¹ F. Akbay,² S. Apaydin.²
¹Urology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey; ²Nephrology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey
INTRODUCTION AND OBJECTIVES: As minimal invasive treatments develop, most urologists have preferred minimally invasive methods in recent years. There is a great shift through laparoscopic…
2017 American Transplant Congress
Neutering Worsens Liver Ischemia/Reperfusion Injury in Both Male and Female Mice.
D. Murken,¹ D. Aufhauser Jr,¹ S. Concors,¹ Z. Wang,¹ G. Ge,¹ W. Hancock,² M. Levine.¹
¹Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA; ²Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
Introduction: Ischemia/reperfusion injury (IRI) causes significant morbidity in liver transplantation and other surgical scenarios. A better understanding of the molecular mechanisms of IRI is required…
2017 American Transplant Congress
Direct Intrahepatic Delivery of Pegylated-Catalase Is Protective in a Rat Ischemia-Reperfusion Injury Model.
E. Beal,¹ S. Black,¹ J. Kim,¹ V. Velazquez,² K. Washburn,¹ D. Hayes Jr.,³ B. Whitson.¹
¹Department of Surgery, Division of Transplant, The Ohio State University Wexner Medical Center, Columbus, OH; ²Center for Vaccines and Immunity, The Research Institute at Nationwide Childrens Hospital, Columbus, OH; ³Departments of Pediatrics and Internal Medicine, The Ohio State University College of Medicine, Columbus, OH
Introduction: Ischemia-reperfusion injury (IRI) is characterized by cessation of blood flow to an organ or tissue leading to accumulation of toxic metabolites and free radicals,…
2017 American Transplant Congress
Down-Regulation of Nuclear HMGB1 by Small Interfering RNA Protects Against Liver Ischemia-Reperfusion Injury.
G. Zhao, C. Fu, L. Wang, L. Zhu, S. Chen, G. Chen.
Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, HUST, Wuhan, Hubei, China
Background:High mobility group box 1 (HMGB1) was found to have both a beneficial intracellular role and injurious extracellular role after a sterile inflammatory insult.Hepatocyte-specific HMGB1…
2017 American Transplant Congress
Estrogen Receptor Alpha Mediates Female Protection from Renal Ischemia-Reperfusion Injury Through Mechanisms Extrinsic to the Kidney.
D. Aufhauser,¹ D. Murken,¹ Z. Wang,¹ G. Ge,¹ S. Concors,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.^1,4
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Surgery, Children's Hospital of Philadelphia, Philadelphia, PA
Introduction: Female protection from renal ischemia-reperfusion injury (IRI) is observed in both mouse and human renal transplantation. We wished to assess the role of estrogen…
2017 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Improves Function of Extreme Marginal Renal Grafts Subjected to Prolonged Ischemia.
P. Urbanellis,¹ M. Hamar,¹ I. Linares,¹ D. Kollmann,¹ C. Cassol,² R. John,² P. Yip,¹ I. Mucsi,¹ A. Ghanekar,¹ D. Bagli,³ D. Grant,¹ L. Robinson,⁴ M. Selzner.¹
¹Multi-Organ Transplant Program, Department of Surgery, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ²Laboratory Medicine and Pathobiology, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ³Departments of Surgery (Urology) and Physiology, The Hospital for Sick Children, Toronto, ON, Canada; ⁴Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
Background: Normothermic ex-vivo kidney perfusion (NEVKP) is an emerging technique for renal graft preservation. We investigated whether NEVKP could promote improved marginal graft function compared…
2017 American Transplant Congress
Histone Deacetylase Inhibition Mitigates Liver Ischemia/Reperfusion Injury in Mice.
D. Murken,¹ D. Aufhauser Jr,¹ S. Concors,¹ Z. Wang,¹ G. Ge,¹ W. Hancock,² M. Levine.¹
¹Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA; ²Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA
Introduction: Ischemia/reperfusion injury (IRI) causes significant morbidity in liver transplantation and other surgical scenarios. A better understanding of the molecular mechanisms of IRI is required…
2017 American Transplant Congress
Nuclear Co-Repressor Complex Inhibition Reverses Benefit of HDAC2 Deletion in Renal Ischemia.
D. Aufhauser Jr,¹ D. Murken,¹ Z. Wang,¹ A. Samanta,² G. Ge,¹ T. Bhatti,³ P. Cole,⁴ J. Kalin,⁴ W. Hancock,^2,3 M. Levine.^1,5
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology, University of Pennsylvania, Philadelphia, PA; ³Pathology, Children's Hospital of Philadelphia, Philadelphia, PA; ⁴Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD; ⁵Surgery, Children's Hospital of Philadelphia, Philadelphia, PA
Introduction: Class I histone/protein deacetylases (HDACs) 1 and 2 bear >85% protein sequence homology and conventionally are thought to have similar function via occupancy in…