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American Transplant Congress abstracts

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Articles tagged "Warm ischemia"

  • 2018 American Transplant Congress

    Histone Deacetylase Inhibition Mitigates Limb Ischemia Reperfusion Injury

    S. Concors,1 D. Aufhauser,1 D. Murken,1 Z. Wang,1 G. Ge,1 T. Bhatti,4 W. Hancock,3,4 M. Levine.1,2

    1Surgery, University of Pennsylvania, Philadelphia, PA; 2Surgery, Children's Hospital of Philadelphia, Philadelphia, PA; 3Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; 4Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.

    Introduction: Vascular composite allotransplantation (VCA) of the limb involves cold and warm ischemia, further limiting organ availability beyond the constraints of blood type, HLA compatibility,…
  • 2018 American Transplant Congress

    In Vivo and In Vitro PPAR-y Activation Decreases M1-Macrophage Polarization and Improves Liver Ischemia Reperfusion Injury

    I. Linares,1 A. Bartczak,1 K. Farrokhi,1 D. Kollmann,1 M. Kaths,1 M. Hamar,1 P. Urbanellis,1 S. Ganesh,1 O. Adeyi,2 P. Yip,3 M. Selzner,1 N. Selzner.1

    1Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada; 2Department of Pathology, Toronto General Hospital, Toronto, ON, Canada; 3Laboratory of Medicine and Pathobiology, Toronto General Hospital, Toronto, ON, Canada.

    Background:M1-Macrophage polarization has been studied as a potential target to decrease inflammatory response in sepsis and inflammation-related diseases. Its role in the setting of inflammatory…
  • 2018 American Transplant Congress

    Donor Hepatectomy Time in Donation after Circulatory Death Donors is an Independent Risk Factor for the Development of Biliary Strictures and Early Graft Loss after Transplantation

    O. van Leeuwen,1 M. van Reeven,2 M. Fujiyoshi,1 V. de Meijer,1 R. de Kleine,1 M. de Boer,1 J. de Jonge,2 J. Ijzermans,2 W. Polak,2 R. Porte.1

    1Department of Surgery, University Medical Center Groningen, Groningen, Netherlands; 2Department of Surgery, Erasmus Medical Center, Rotterdam, Netherlands.

    Introduction: Liver transplantation (LT) from donors after circulatory death (DCD) is associated with an increased risk of non-anastomotic biliary strictures (NAS) and early graft loss…
  • 2018 American Transplant Congress

    A Proteomic Analysis of Kidneys Subjected to Normothermic Ex Vivo Kidney Perfusion (NEVKP) Demonstrates That Metabolism is an Important Determinant of Kidney Function Following Warm Ischemia

    A. Konvalinka,1,4 T. Tokar,2 S. Reid,4 P. Urbanellis,4 M. Hamar,4 M. Kaths,4 I. Jurisica,2 L. Robinson,4,3 M. Selzner.4,5

    1Medicine/Nephrology, University Health Network, Toronto, ON, Canada; 2Medical Biophysics/Computer Science, University of Toronto, Toronto, ON, Canada; 3Pediatrics/Nephrology, Hospital for Sick Children, Toronto, ON, Canada; 4Institute of Medical Science, University of Toronto, Toronto, ON, Canada; 5Surgery/General Surgery, University Health Network, Toronto, ON, Canada.

    Kidney transplantation reduces mortality compared to staying on dialysis, incentivizing the use of marginal kidneys in face of organ shortage. These marginal kidneys after cardiocirculatory…
  • 2018 American Transplant Congress

    GDF15 Preventing Renal Ischemia Reperfusion Injury

    C. Zhu,1,2 A. Patel,1 Y. Su,1,2 J. Jiang,1 D. Lian,1 A. Sener,1 W. Min,1 P. Luke,1 D. Quan,1 K. Liu,2 X. Zheng.1

    1University of Western Ontario, London, ON, Canada; 2Jilin University, ChangChun, China.

    Rationale: Ischemia reperfusion (I/R) injury still remains one of main causes of early renal dysfunction in kidney transplantation. There are no effective treatments for preventing…
  • 2017 American Transplant Congress

    Warm Ischemic Time as an Additive Predictor of Graft Survival in KDPI/KDRI Era of Kidneys from Donors After Cardiac Death: A Single-Center Experience Over Three Decades.

    M. Kusaka,1 Y. Kubota,1 H. Takahashi,2 H. Sasaki,1 M. Takenaka,1 N. Fukami,1 T. Kenmochi,3 R. Shiroki,1 K. Hoshinaga.1

    1Urology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; 2Division of Medical Statistics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; 3Organ Transplant Surgery, Fujita Health University School of Medicine, Toyoake, Aichi, Japan

    It is important to predict the outcome of grafts prior to kidney transplantation and establish an appropriate allocation system, particularly to consider expanded criteria donors…
  • 2017 American Transplant Congress

    Beneficial Effects of Hydrogen Sulfide (H2S) on Renal Ischemia-Reperfusion Injury (IRI) in CLAWN Miniature Swine.

    Y. Ariyoshi, M. Sekijima, H. Sahara, T. Murokawa, A. Shimizu, K. Yamada.

    Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan

    Objective: The prevention of IRI is important for both early and long-term graft function, especially when using extended-criteria or donation after cardiac donors. H2S has…
  • 2017 American Transplant Congress

    Dendritic Cell Expression of Rictor (mTORC2), but Not Raptor (mTORC1), Protects Against Renal Ischemia-Reperfusion Injury.

    H. Dai,1,3 N. Rogers,1,2 A. Watson,1 D. Fantus,1 A. Thomson.1

    1Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; 2Westmead Institute for Medical Research, Sydney, Australia; 3Urologic Organ Transplantation Department, the Second Xiangya Hospital, Central South University, Changsha, China

    Background: Dendritic cells (DC) are critical initiators of innate immunity in the kidney and orchestrate inflammation subsequent to ischemia-reperfusion injury (IRI). The mechanistic target of…
  • 2017 American Transplant Congress

    Objective Assessment of Graft Metabolism and Function During Ex Vivo Liver Perfusion.

    J. Echeverri,1 S. Cleland,2 M. Kaths,1 I. Linares,1 R. Roizales,1 N. Goldaracena,1 D. Kollmann,1 M. Hamar,1 P. Urbanellis,1 S. Ganesh,1 O. Adeyi,3 D. Grant,1 N. Selzner,4 M. Wasowicz,2 M. Selzner.1

    1Multi-Organ Transplant Program, Department of Surgery, University of Toronto - Toronto General Hospital, Toronto, ON, Canada; 2Multi-Organ Transplant Program, Department of Anesthesia, University of Toronto - Toronto General Hospital, Toronto, ON, Canada; 3Multi-Organ Transplant Program, Department of Pathology, University of Toronto - Toronto General Hospital, Toronto, ON, Canada; 4Multi-Organ Transplant Program, Department of Medicine, University of Toronto - Toronto General Hospital, Toronto, ON, Canada

    During EVLP no objective perfusion parameters have been found to predict outcome after transplantation.Methods: Livers with 4grades of injury were perfused for 4 hours and…
  • 2017 American Transplant Congress

    Ex-Situ Extended Limb Preservation: A Protocol for Porcine Limb Perfusion.

    E. Dalla Pozza,1 E. Duraes,1 M. Madajka,1 R. Frautschi,1 K. Cho,1 N. Dawlagala,1 V. Fahradyan,1 H. Shah,1 C. Cakmakoglu,1 C. Quintini,2 F. Papay,1 A. Rampazzo,1 B. Bassiri Gharb.1

    1Plastic Surgery, Cleveland Clinic, Cleveland, OH; 2General Surgery, Cleveland Clinic, Cleveland, OH

    Background: Ischemia and reperfusion injury remains a significant limiting factor for the success of vascularized composite allotransplantation. Compared to the cold storage of the procured…
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