Articles tagged "Warm ischemia"

2018 American Transplant Congress
Histone Deacetylase Inhibition Mitigates Limb Ischemia Reperfusion Injury
S. Concors,¹ D. Aufhauser,¹ D. Murken,¹ Z. Wang,¹ G. Ge,¹ T. Bhatti,⁴ W. Hancock,^3,4 M. Levine.^1,2
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Surgery, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Vascular composite allotransplantation (VCA) of the limb involves cold and warm ischemia, further limiting organ availability beyond the constraints of blood type, HLA compatibility,…
2018 American Transplant Congress
In Vivo and In Vitro PPAR-y Activation Decreases M1-Macrophage Polarization and Improves Liver Ischemia Reperfusion Injury
I. Linares,¹ A. Bartczak,¹ K. Farrokhi,¹ D. Kollmann,¹ M. Kaths,¹ M. Hamar,¹ P. Urbanellis,¹ S. Ganesh,¹ O. Adeyi,² P. Yip,³ M. Selzner,¹ N. Selzner.¹
¹Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada; ²Department of Pathology, Toronto General Hospital, Toronto, ON, Canada; ³Laboratory of Medicine and Pathobiology, Toronto General Hospital, Toronto, ON, Canada.
Background:M1-Macrophage polarization has been studied as a potential target to decrease inflammatory response in sepsis and inflammation-related diseases. Its role in the setting of inflammatory…
2018 American Transplant Congress
Donor Hepatectomy Time in Donation after Circulatory Death Donors is an Independent Risk Factor for the Development of Biliary Strictures and Early Graft Loss after Transplantation
O. van Leeuwen,¹ M. van Reeven,² M. Fujiyoshi,¹ V. de Meijer,¹ R. de Kleine,¹ M. de Boer,¹ J. de Jonge,² J. Ijzermans,² W. Polak,² R. Porte.¹
¹Department of Surgery, University Medical Center Groningen, Groningen, Netherlands; ²Department of Surgery, Erasmus Medical Center, Rotterdam, Netherlands.
Introduction: Liver transplantation (LT) from donors after circulatory death (DCD) is associated with an increased risk of non-anastomotic biliary strictures (NAS) and early graft loss…
2018 American Transplant Congress
A Proteomic Analysis of Kidneys Subjected to Normothermic Ex Vivo Kidney Perfusion (NEVKP) Demonstrates That Metabolism is an Important Determinant of Kidney Function Following Warm Ischemia
A. Konvalinka,^1,4 T. Tokar,² S. Reid,⁴ P. Urbanellis,⁴ M. Hamar,⁴ M. Kaths,⁴ I. Jurisica,² L. Robinson,^4,3 M. Selzner.^4,5
¹Medicine/Nephrology, University Health Network, Toronto, ON, Canada; ²Medical Biophysics/Computer Science, University of Toronto, Toronto, ON, Canada; ³Pediatrics/Nephrology, Hospital for Sick Children, Toronto, ON, Canada; ⁴Institute of Medical Science, University of Toronto, Toronto, ON, Canada; ⁵Surgery/General Surgery, University Health Network, Toronto, ON, Canada.
Kidney transplantation reduces mortality compared to staying on dialysis, incentivizing the use of marginal kidneys in face of organ shortage. These marginal kidneys after cardiocirculatory…
2018 American Transplant Congress
GDF15 Preventing Renal Ischemia Reperfusion Injury
C. Zhu,^1,2 A. Patel,¹ Y. Su,^1,2 J. Jiang,¹ D. Lian,¹ A. Sener,¹ W. Min,¹ P. Luke,¹ D. Quan,¹ K. Liu,² X. Zheng.¹
¹University of Western Ontario, London, ON, Canada; ²Jilin University, ChangChun, China.
Rationale: Ischemia reperfusion (I/R) injury still remains one of main causes of early renal dysfunction in kidney transplantation. There are no effective treatments for preventing…
2017 American Transplant Congress
Nuclear Co-Repressor Complex Inhibition Reverses Benefit of HDAC2 Deletion in Renal Ischemia.
D. Aufhauser Jr,¹ D. Murken,¹ Z. Wang,¹ A. Samanta,² G. Ge,¹ T. Bhatti,³ P. Cole,⁴ J. Kalin,⁴ W. Hancock,^2,3 M. Levine.^1,5
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology, University of Pennsylvania, Philadelphia, PA; ³Pathology, Children's Hospital of Philadelphia, Philadelphia, PA; ⁴Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD; ⁵Surgery, Children's Hospital of Philadelphia, Philadelphia, PA
Introduction: Class I histone/protein deacetylases (HDACs) 1 and 2 bear >85% protein sequence homology and conventionally are thought to have similar function via occupancy in…
2017 American Transplant Congress
Longer Anastomotic Time Leads to Delayed Graft Function.
M. Heer,^1,2 P. Trevillian,^1,2,3 A. Hibberd.^1,2,3
¹Newcastle Transplant Unit, John Hunter Hospital, Newcastle, NSW, Australia; ²Newcastle University, Newcastle, NSW, Australia; ³Hunter Transplant Research Foundation, Hunter Medical Research Institute, Newcastle, NSW, Australia
Background: Delayed graft function (DGF) occurs at variable rates in renal transplant recipients. It can be deleterious to renal allograft in long term. Various factors…
2017 American Transplant Congress
Lactate Level Immediate Post-Liver Transplantation Is a Predictor of Early Allograft Dysfunction.
K. Takahashi,^1,2 S. Nagai,¹ M. Safwan,¹ K. Putchakayala,¹ K. Collins,¹ M. Rizzari,¹ A. Yoshida,¹ M. Abouljoud,¹ S.-M. Jafri.³
¹Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; ²Surgery, University of Tsukuba, Tsukuba, Ibaraki, Japan; ³Gastroenterology, Henry Ford Hospital, Detroit, MI
Background; Early allograft dysfunction (EAD) after liver transplantation (LT) is defined as a peak values of aminotransferase >2000 IU/mL during the first week or an…
2017 American Transplant Congress
Controlled Donation After Circulatory Death (cDCD) Donors May Become Similar to Brain Death Donors (DBD).
C. Antoine,¹ M. Videcoq,² B. Riou,³ D. Dorez,⁴ G. Cheisson,⁵ L. Martin-Lefèvre,⁶ L. Durand,¹ E. Savoye,¹ G. Karam,² B. Barrou.³
¹Agence de la Biomedecine, Saint Denis La Plaine, France; ²University Hospital, Nantes, France; ³University Hospital La Pitie, Paris, France; ⁴Hospital, Annecy, France; ⁵University Hospital, Kremlin Bicetre, France; ⁶Hospital, La Roche Sur Yon, France
Since 2014 in France, we started a cDCD program characterized by the introduction of normothermia regional perfusion (nRP) and selection criteria as donor age ≤65…
2017 American Transplant Congress
Warm Ischemic Time as an Additive Predictor of Graft Survival in KDPI/KDRI Era of Kidneys from Donors After Cardiac Death: A Single-Center Experience Over Three Decades.
M. Kusaka,¹ Y. Kubota,¹ H. Takahashi,² H. Sasaki,¹ M. Takenaka,¹ N. Fukami,¹ T. Kenmochi,³ R. Shiroki,¹ K. Hoshinaga.¹
¹Urology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; ²Division of Medical Statistics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan; ³Organ Transplant Surgery, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
It is important to predict the outcome of grafts prior to kidney transplantation and establish an appropriate allocation system, particularly to consider expanded criteria donors…

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