Articles tagged "Warm ischemia"

2019 American Transplant Congress
Cryopreserved Human Iliac Arteries Allografts: Different Thawing Rates Affect on Their Structural Changes and Mechanical Properties
R. Novotny¹, J. Chlupac¹, R. Matejka², T. Marada¹, P. Mericka³, L. Sterba³, L. Janousek¹, J. Fronek¹
¹Transplant Surgery Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Department of Biomedical Engineerin, Faculty of Biomedical Engineering, Czech Technical University, Prague, Czech Republic, ³Tissue Bank, Faculty Hospital Hradec Kralove, Hradec Kralove, Czech Republic
*Purpose: The rate of thawing of cryopreserved human iliac arteries allografts (CHIAA) directly affects the severeness of structural changes that occur during this process. This…
2019 American Transplant Congress
Inhibition of Cyclin-Dependent Kinase 2 Signaling Prevents Liver Ischemia and Reperfusion Injury
Z. Xue, J. Xu, C. Zhang, Y. Liu, R. Busuttil, J. Kupiec-Weglinski, H. Ji
Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Hepatic ischemia/reperfusion injury (IRI), an exogenous antigen-independent local inflammation response, occurs in multiple clinical settings including liver transplantation, hepatic resection, trauma, and shock. The…
2019 American Transplant Congress
Combined Ischemic and Rapamycin Preconditioning Alleviated Liver Ischemia and Reperfusion Injury by Restoring Autophagy in Old Mice
Z. Rao, X. Pan, W. Zhong, Z. Ding, H. Zhou, C. Liu
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Old livers are more damaged by hepatic ischemia and reperfusion (IR) injury than young livers. The aim of this study was to investigate the…
2019 American Transplant Congress
Epithelial to Mesenchymal Transition: A Cellular Mediator of Ischemic Cholangiopathy after Liver Transplant
N. A. Wickramaratne¹, R. Li², R. C. Fyffe-Freil², T. Tian², M. J. Mangino²
¹VCUHealth, Richmond, VA, ²Department of Surgery, VCUHealth, Richmond, VA
*Purpose: Epithelial-to-mesenchymal transition (EMT) is a genetic reprogramming that causes epithelial cells to assume a migratory, mesenchymal phenotype, and it is induced by hypoxia. Ischemic…
2019 American Transplant Congress
Quantitative Proteomics Analysis of Ischemia Reperfusion Injured Liver Tissue Provides Insight into Liver Allograft Quality Evaluation
M. Chen, M. Han, W. Ju, Q. Zhao, D. Wang, Z. Guo, X. He
Transplant Center, Sun Yat-sen University, Guangzhou, China
*Purpose: Successful orthotopic liver transplantation (OLT) surgery mostly depends on good and functional liver donor, besides of mature transplant technology. The molecular basis of different…
2019 American Transplant Congress
Sequestration of PLIN2 Regulates High-Fat Diet Induced Metabolic Syndrome and Nonalcoholic Fatty Liver Disease in a Mouse Model of Ischemia Reperfusion Injury
K. Loh¹, X. Liu¹, L. Belyayev¹, C. Albanese², W. Cui¹, T. M. Fishbein¹, K. M. Khan¹, A. Kroemer¹
¹Transplant, MedStar Georgetown Transplant Institute, Washington, DC, ²Oncology, Georgetown University, Washington, DC
*Purpose: This study aimed to define characteristics and mechanisms leading to nonalcoholic fatty liver disease and metabolic syndrome in a fatty liver mouse model that…
2019 American Transplant Congress
The Impact of Reduction of Warm Ischemia on DCD Kidney Transplantation Outcomes
S. Aquil, D. Wonjoon, M. Levine, R. Al Ogaili, A. Sener, P. Luke
Department of Surgery, Multi Organ Transplant Program, Western University Hospital, LHSC, London, ON, Canada
*Purpose: Warm ischemic time (WIT) during donation after cardiac death (DCD) kidney transplantation has significant effects on post-operative outcomes, such as graft survival, function, and…
2019 American Transplant Congress
Analysis of Lactic Acid Response in Renal Transplant Patients
A. A. Henderson¹, H. Ahmed², M. R. Wakefield¹
¹Surgery/Urology, University of Missouri School of Medicine, Columbia, MO, ²University of Missouri School of Medicine, Columbia, MO
*Purpose: Lactic acid (LA) serves as an important biomarker in the evaluation of ischemia, sepsis, metabolic acidosis, and trauma. During renal transplantation (RT), there is…
2019 American Transplant Congress
Novel Cooling Device for Kidney Transplant Surgery
A. Dergham¹, L. Witherspoon², T. A. Skinner²
¹Department of Medicine, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada, ²Division of Urology, Department of Surgery, The Ottawa Hospital and University of Ottawa, Ottawa, ON, Canada
*Purpose: Metabolic activity in cooled kidneys is minimal at 5ºC and resumes above 15ºC, a temperature reached after only 15 min of warm ischemia time…
2018 American Transplant Congress
A Proteomic Analysis of Kidneys Subjected to Normothermic Ex Vivo Kidney Perfusion (NEVKP) Demonstrates That Metabolism is an Important Determinant of Kidney Function Following Warm Ischemia
A. Konvalinka,^1,4 T. Tokar,² S. Reid,⁴ P. Urbanellis,⁴ M. Hamar,⁴ M. Kaths,⁴ I. Jurisica,² L. Robinson,^4,3 M. Selzner.^4,5
¹Medicine/Nephrology, University Health Network, Toronto, ON, Canada; ²Medical Biophysics/Computer Science, University of Toronto, Toronto, ON, Canada; ³Pediatrics/Nephrology, Hospital for Sick Children, Toronto, ON, Canada; ⁴Institute of Medical Science, University of Toronto, Toronto, ON, Canada; ⁵Surgery/General Surgery, University Health Network, Toronto, ON, Canada.
Kidney transplantation reduces mortality compared to staying on dialysis, incentivizing the use of marginal kidneys in face of organ shortage. These marginal kidneys after cardiocirculatory…

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