2019 American Transplant Congress
Utilization of DCD Donors >50 Years Old for Liver Transplantation
Arizona Transplant Associates, PC, Phoenix, AZ
*Purpose: End stage liver disease is becoming more prevalent in the United States with approximately 4.9 million adults carrying the diagnosis. It is estimated that…2019 American Transplant Congress
Histone Deacetylase-2 Knockout in Renal Tubular Cells is Protective in Renal Ischemia-Reperfusion Injury
*Purpose: Ischemia-reperfusion injury (IRI) is a major source of morbidity in renal transplantation and is without targeted therapy. In renal transplantation, IRI contributes to poorer…2019 American Transplant Congress
Incidence of Autoresuscitation in Donation after Cardiac Death Donors
*Purpose: Donation after cardiac death (DCD) donors are subject to an observation period after asystole to monitor for cardiopulmonary autoresuscitation (AR). Periods vary between and…2019 American Transplant Congress
Effects of Static Subnormothermic Preservation of Extended Warm Ischemic Porcine Kidneys Assessed by Ex-Vivo Machine Perfusion and Renal Transplant Model
Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan
*Purpose: The donation after circulatory death (DCD) donors has the potential to match the increasing need for transplantable organs, however, DCD kidneys have a higher…2019 American Transplant Congress
Cryopreserved Human Iliac Arteries Allografts: Different Thawing Rates Affect on Their Structural Changes and Mechanical Properties
*Purpose: The rate of thawing of cryopreserved human iliac arteries allografts (CHIAA) directly affects the severeness of structural changes that occur during this process. This…2019 American Transplant Congress
Inhibition of Cyclin-Dependent Kinase 2 Signaling Prevents Liver Ischemia and Reperfusion Injury
Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Hepatic ischemia/reperfusion injury (IRI), an exogenous antigen-independent local inflammation response, occurs in multiple clinical settings including liver transplantation, hepatic resection, trauma, and shock. The…2019 American Transplant Congress
Combined Ischemic and Rapamycin Preconditioning Alleviated Liver Ischemia and Reperfusion Injury by Restoring Autophagy in Old Mice
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Old livers are more damaged by hepatic ischemia and reperfusion (IR) injury than young livers. The aim of this study was to investigate the…2019 American Transplant Congress
Epithelial to Mesenchymal Transition: A Cellular Mediator of Ischemic Cholangiopathy after Liver Transplant
1VCUHealth, Richmond, VA, 2Department of Surgery, VCUHealth, Richmond, VA
*Purpose: Epithelial-to-mesenchymal transition (EMT) is a genetic reprogramming that causes epithelial cells to assume a migratory, mesenchymal phenotype, and it is induced by hypoxia. Ischemic…2019 American Transplant Congress
Quantitative Proteomics Analysis of Ischemia Reperfusion Injured Liver Tissue Provides Insight into Liver Allograft Quality Evaluation
Transplant Center, Sun Yat-sen University, Guangzhou, China
*Purpose: Successful orthotopic liver transplantation (OLT) surgery mostly depends on good and functional liver donor, besides of mature transplant technology. The molecular basis of different…2018 American Transplant Congress
Extra-Renal Effects of Estrogen Receptor-Alpha Mediate Protection from Renal Ischemia-Reperfusion Injury
Introduction: Females exhibit protection from renal ischemia-reperfusion injury (IRI) compared to males in animal models and in human kidneys transplants. Previous experiments have shown that…
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