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American Transplant Congress abstracts

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Articles tagged "Warm ischemia"

  • 2019 American Transplant Congress

    Cryopreserved Human Iliac Arteries Allografts: Different Thawing Rates Affect on Their Structural Changes and Mechanical Properties

    R. Novotny1, J. Chlupac1, R. Matejka2, T. Marada1, P. Mericka3, L. Sterba3, L. Janousek1, J. Fronek1

    1Transplant Surgery Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2Department of Biomedical Engineerin, Faculty of Biomedical Engineering, Czech Technical University, Prague, Czech Republic, 3Tissue Bank, Faculty Hospital Hradec Kralove, Hradec Kralove, Czech Republic

    *Purpose: The rate of thawing of cryopreserved human iliac arteries allografts (CHIAA) directly affects the severeness of structural changes that occur during this process. This…
  • 2019 American Transplant Congress

    Inhibition of Cyclin-Dependent Kinase 2 Signaling Prevents Liver Ischemia and Reperfusion Injury

    Z. Xue, J. Xu, C. Zhang, Y. Liu, R. Busuttil, J. Kupiec-Weglinski, H. Ji

    Dumont-UCLA Transplant Center, Los Angeles, CA

    *Purpose: Hepatic ischemia/reperfusion injury (IRI), an exogenous antigen-independent local inflammation response, occurs in multiple clinical settings including liver transplantation, hepatic resection, trauma, and shock. The…
  • 2019 American Transplant Congress

    Combined Ischemic and Rapamycin Preconditioning Alleviated Liver Ischemia and Reperfusion Injury by Restoring Autophagy in Old Mice

    Z. Rao, X. Pan, W. Zhong, Z. Ding, H. Zhou, C. Liu

    The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: Old livers are more damaged by hepatic ischemia and reperfusion (IR) injury than young livers. The aim of this study was to investigate the…
  • 2019 American Transplant Congress

    Epithelial to Mesenchymal Transition: A Cellular Mediator of Ischemic Cholangiopathy after Liver Transplant

    N. A. Wickramaratne1, R. Li2, R. C. Fyffe-Freil2, T. Tian2, M. J. Mangino2

    1VCUHealth, Richmond, VA, 2Department of Surgery, VCUHealth, Richmond, VA

    *Purpose: Epithelial-to-mesenchymal transition (EMT) is a genetic reprogramming that causes epithelial cells to assume a migratory, mesenchymal phenotype, and it is induced by hypoxia. Ischemic…
  • 2019 American Transplant Congress

    Quantitative Proteomics Analysis of Ischemia Reperfusion Injured Liver Tissue Provides Insight into Liver Allograft Quality Evaluation

    M. Chen, M. Han, W. Ju, Q. Zhao, D. Wang, Z. Guo, X. He

    Transplant Center, Sun Yat-sen University, Guangzhou, China

    *Purpose: Successful orthotopic liver transplantation (OLT) surgery mostly depends on good and functional liver donor, besides of mature transplant technology. The molecular basis of different…
  • 2019 American Transplant Congress

    Sequestration of PLIN2 Regulates High-Fat Diet Induced Metabolic Syndrome and Nonalcoholic Fatty Liver Disease in a Mouse Model of Ischemia Reperfusion Injury

    K. Loh1, X. Liu1, L. Belyayev1, C. Albanese2, W. Cui1, T. M. Fishbein1, K. M. Khan1, A. Kroemer1

    1Transplant, MedStar Georgetown Transplant Institute, Washington, DC, 2Oncology, Georgetown University, Washington, DC

    *Purpose: This study aimed to define characteristics and mechanisms leading to nonalcoholic fatty liver disease and metabolic syndrome in a fatty liver mouse model that…
  • 2019 American Transplant Congress

    The Impact of Reduction of Warm Ischemia on DCD Kidney Transplantation Outcomes

    S. Aquil, D. Wonjoon, M. Levine, R. Al Ogaili, A. Sener, P. Luke

    Department of Surgery, Multi Organ Transplant Program, Western University Hospital, LHSC, London, ON, Canada

    *Purpose: Warm ischemic time (WIT) during donation after cardiac death (DCD) kidney transplantation has significant effects on post-operative outcomes, such as graft survival, function, and…
  • 2019 American Transplant Congress

    Analysis of Lactic Acid Response in Renal Transplant Patients

    A. A. Henderson1, H. Ahmed2, M. R. Wakefield1

    1Surgery/Urology, University of Missouri School of Medicine, Columbia, MO, 2University of Missouri School of Medicine, Columbia, MO

    *Purpose: Lactic acid (LA) serves as an important biomarker in the evaluation of ischemia, sepsis, metabolic acidosis, and trauma. During renal transplantation (RT), there is…
  • 2019 American Transplant Congress

    Novel Cooling Device for Kidney Transplant Surgery

    A. Dergham1, L. Witherspoon2, T. A. Skinner2

    1Department of Medicine, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada, 2Division of Urology, Department of Surgery, The Ottawa Hospital and University of Ottawa, Ottawa, ON, Canada

    *Purpose: Metabolic activity in cooled kidneys is minimal at 5ºC and resumes above 15ºC, a temperature reached after only 15 min of warm ischemia time…
  • 2018 American Transplant Congress

    A Proteomic Analysis of Kidneys Subjected to Normothermic Ex Vivo Kidney Perfusion (NEVKP) Demonstrates That Metabolism is an Important Determinant of Kidney Function Following Warm Ischemia

    A. Konvalinka,1,4 T. Tokar,2 S. Reid,4 P. Urbanellis,4 M. Hamar,4 M. Kaths,4 I. Jurisica,2 L. Robinson,4,3 M. Selzner.4,5

    1Medicine/Nephrology, University Health Network, Toronto, ON, Canada; 2Medical Biophysics/Computer Science, University of Toronto, Toronto, ON, Canada; 3Pediatrics/Nephrology, Hospital for Sick Children, Toronto, ON, Canada; 4Institute of Medical Science, University of Toronto, Toronto, ON, Canada; 5Surgery/General Surgery, University Health Network, Toronto, ON, Canada.

    Kidney transplantation reduces mortality compared to staying on dialysis, incentivizing the use of marginal kidneys in face of organ shortage. These marginal kidneys after cardiocirculatory…
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