Articles tagged "Warm ischemia"

2020 American Transplant Congress
The Impact of Transportation Innovation for Human Organs: Surgical Perspectives and Implications
T. Talaie, S. Niederhaus, E. Villalonga, J. Bromberg, J. Scalea
Transplant Surgery, Unviersity of Maryland Medical Center, Baltimore, MD
*Purpose: Recent changes in allocation and the ongoing organ donor shortage have led to increased regional and national sharing, putting intense pressure on the organ…
2020 American Transplant Congress
DCD vs DBD Liver Transplantation: Equivalent Charges and Similar Survival- An Effective Expansion of the Donor Pool
N. Singh, K. Helfrich, M. Alebrahim, C. Akateh, K. Mumtaz, A. Logan, A. Schenk, S. Black, E. Elkhammas, K. Washburn, A. El-Hinnawi
Ohio State University, Columbus, OH
*Purpose: The shortage of allografts available for liver transplantation (LT) has prompted the need for expansion of donor pool to include donation after circulatory death…
2020 American Transplant Congress
Activation of YAP Attenuates Hepatic Damage and Fibrosis in Liver Ischemia-Reperfusion Injury: From Bench to Bedside
Y. Liu¹, T. Lu², C. Zhang¹, Z. Xue¹, R. Busuttil¹, J. Kupiec-Weglinski¹, H. Ji¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²Shanghai Jiaotong University, Shanghai, China
*Purpose: Hepatic ischemia-reperfusion injury (IRI) is a major complication of hemorrhagic shock, liver resection and transplantation. YAP, the effector of Hippo pathway, is essential in…
2020 American Transplant Congress
Genome-Wide Transcriptome Analysis of Extreme Marginal Renal Grafts Indicates Earlier Repair and Less Damage Following Normothermic Ex-Vivo Kidney Perfusion Preservation
P. Urbanellis¹, L. Mazilescu¹, C. McEvoy¹, S. Ganesh¹, R. John¹, I. Mucsi¹, A. Ghanekar¹, D. Bagli², A. Konvalinka¹, L. Robinson¹, M. Selzner¹
¹University Health Network, Toronto, ON, Canada, ²The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) was shown to prevent delayed graft function of kidneys subjected to prolonged warm ischemia (WI) compared to static cold…
2020 American Transplant Congress
Potential to Regenerate Damaged Allografts
L. Brasile¹, B. Stubentisky²
¹Research and Development, Breonics Inc., Watervliet, NY, ²Plastic, Reconstructive & Aesthetic Surgery, St. Antonius Hospital, Utrecht, Netherlands
*Purpose: The chronic shortage of allografts has generated intense interest in the field of regenerative medicine. Given the limited regeneration that can be accomplished in…
2019 American Transplant Congress
Sequestration of PLIN2 Regulates High-Fat Diet Induced Metabolic Syndrome and Nonalcoholic Fatty Liver Disease in a Mouse Model of Ischemia Reperfusion Injury
K. Loh¹, X. Liu¹, L. Belyayev¹, C. Albanese², W. Cui¹, T. M. Fishbein¹, K. M. Khan¹, A. Kroemer¹
¹Transplant, MedStar Georgetown Transplant Institute, Washington, DC, ²Oncology, Georgetown University, Washington, DC
*Purpose: This study aimed to define characteristics and mechanisms leading to nonalcoholic fatty liver disease and metabolic syndrome in a fatty liver mouse model that…
2019 American Transplant Congress
The Impact of Reduction of Warm Ischemia on DCD Kidney Transplantation Outcomes
S. Aquil, D. Wonjoon, M. Levine, R. Al Ogaili, A. Sener, P. Luke
Department of Surgery, Multi Organ Transplant Program, Western University Hospital, LHSC, London, ON, Canada
*Purpose: Warm ischemic time (WIT) during donation after cardiac death (DCD) kidney transplantation has significant effects on post-operative outcomes, such as graft survival, function, and…
2019 American Transplant Congress
Analysis of Lactic Acid Response in Renal Transplant Patients
A. A. Henderson¹, H. Ahmed², M. R. Wakefield¹
¹Surgery/Urology, University of Missouri School of Medicine, Columbia, MO, ²University of Missouri School of Medicine, Columbia, MO
*Purpose: Lactic acid (LA) serves as an important biomarker in the evaluation of ischemia, sepsis, metabolic acidosis, and trauma. During renal transplantation (RT), there is…
2019 American Transplant Congress
Novel Cooling Device for Kidney Transplant Surgery
A. Dergham¹, L. Witherspoon², T. A. Skinner²
¹Department of Medicine, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada, ²Division of Urology, Department of Surgery, The Ottawa Hospital and University of Ottawa, Ottawa, ON, Canada
*Purpose: Metabolic activity in cooled kidneys is minimal at 5ºC and resumes above 15ºC, a temperature reached after only 15 min of warm ischemia time…
2019 American Transplant Congress
Robotic-Assisted versus Open Techniques for Living Donor Kidney Transplant Recipients: A Comparison Using Propensity Score Analysis
F. Tinney, J. Stracke, S. Nagai, L. Malinzak, T. McEvoy, S. Mohamed Ilias, A. Yoshida
Transplant Institute, Henry Ford Hospital, Detroit, MI
*Purpose: Following rapid advancements in minimally invasive urology, living donor robotic-assisted kidney transplantation (RAKT) has developed into a feasible alternative to open kidney transplantation (OKT).…