ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Warm ischemia"

  • 2020 American Transplant Congress

    HMGB1 Antagonizes the Immunosuppressive Effect of MSCs in AKI

    S. Cai1, S. Wang2, W. Zhang2, A. Chandraker1, C. Yang2, T. Zhu2

    1Renal Division, Brigham and Women's Hospital, Boston, MA, 2Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China

    *Purpose: Kidney ischemia reperfusion injury (IRI) is a common cause of acute kidney injury and an unavoidable consequence of kidney transplantation and still lacks specific…
  • 2020 American Transplant Congress

    Short Recipient Warm Ischemia Time Improves Graft Survival in Liver Transplantation from Donation after Brain Death: 20-Year Experience of Liver Transplantation

    A. Al-Kurd, T. Kitajima, K. Delvecchio, A. M. Elsabbagh, S. Yeddula, M. Rizzari, K. Collins, A. Yoshida, M. Abouljoud, S. Nagai

    Transplant Institute, Henry Ford Hospital, Detroit, MI

    *Purpose: Although the correlation between warm ischemia time (WIT) and the outcomes of liver transplantation has been extensively studied, few investigations have focused on the…
  • 2020 American Transplant Congress

    Benefits of Normothermia Regional Perfusion (NRP), Hypothermic Machine Perfusion (HMP) and Short Cold Ischemia Time (CIT) for Kidney Transplants with Controlled Donation after Circulatory Death (cDCD)

    E. Savoye1, C. Legeai1, J. Branchereau2, S. Gay3, S. Drouin4, F. Gaudez5, B. Veber6, J. Venhard7, G. Cheisson8, T. Kerforne9, O. Bastien1, C. Antoine1

    1Agence de la Biomedecine, La Plaine Saint Denis, France, 2CHU Nantes, Nantes, France, 3CH Annecy, Annecy, France, 4CHU Pitié Salpetriere, Paris, France, 5CHU Saint Louis, Paris, France, 6CHU Rouen, Rouen, France, 7CHU Tours, Tours, France, 8CHU Kremlin-Bicetre, Kremlin-Bicetre, France, 9CHU Poitiers, Poitiers, France

    *Purpose: cDCD are considered as extended criteria donors with poorer kidney transplant outcomes and high delayed graft function (DGF) rate. We built a French national…
  • 2020 American Transplant Congress

    Roles of Calpastatin in Ischemia/Reperfusion Injury in Aged Livers

    J. Kim, C. Lee, W. Chapman

    Surgery, Washington University St. Louis, St. Louis, MO

    *Purpose: Aged livers are far more susceptible to ischemia/reperfusion (I/R) injury than young livers. No therapeutic strategies are available to reduce I/R injury in elderly…
  • 2020 American Transplant Congress

    Initial North American Experience in Renal Transplantation from Medical Assistance in Dying Donors

    M. A. Levine, S. Sami, A. Sener, P. Luke

    Surgery, London Health Sciences Centre, London, ON, Canada

    *Purpose: In 2016, Canadian federal legislation was passed creating a regulatory framework for medical assistance in dying (MAiD) for individuals who are suffering from a…
  • 2019 American Transplant Congress

    Histone Deacetylase-2 Knockout in Renal Tubular Cells is Protective in Renal Ischemia-Reperfusion Injury

    P. T. Hernandez1, S. J. Concors1, L. Krumeich1, D. D. Aufhauser1, Z. Wang1, D. D. Murken1, G. Ge1, W. Hancock2, M. Levine3

    1General Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, 2Pathology, Children's Hospital of Philadelphia, Philadelphia, PA, 3Transplant Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA

    *Purpose: Ischemia-reperfusion injury (IRI) is a major source of morbidity in renal transplantation and is without targeted therapy. In renal transplantation, IRI contributes to poorer…
  • 2019 American Transplant Congress

    Incidence of Autoresuscitation in Donation after Cardiac Death Donors

    C. W. Koo1, R. A. Helmick1, K. Van Frank2, K. Gilley2, J. D. Eason1

    1UTHSC / Methodist University Hospital Transplant Institute, Memphis, TN, 2Mid South Transplant Foundation, Memphis, TN

    *Purpose: Donation after cardiac death (DCD) donors are subject to an observation period after asystole to monitor for cardiopulmonary autoresuscitation (AR). Periods vary between and…
  • 2019 American Transplant Congress

    Effects of Static Subnormothermic Preservation of Extended Warm Ischemic Porcine Kidneys Assessed by Ex-Vivo Machine Perfusion and Renal Transplant Model

    H. Sahara, Y. Ariyoshi, M. Sekijima, T. Iwanaga, A. Shimizu, K. Yamada

    Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan

    *Purpose: The donation after circulatory death (DCD) donors has the potential to match the increasing need for transplantable organs, however, DCD kidneys have a higher…
  • 2019 American Transplant Congress

    Cryopreserved Human Iliac Arteries Allografts: Different Thawing Rates Affect on Their Structural Changes and Mechanical Properties

    R. Novotny1, J. Chlupac1, R. Matejka2, T. Marada1, P. Mericka3, L. Sterba3, L. Janousek1, J. Fronek1

    1Transplant Surgery Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2Department of Biomedical Engineerin, Faculty of Biomedical Engineering, Czech Technical University, Prague, Czech Republic, 3Tissue Bank, Faculty Hospital Hradec Kralove, Hradec Kralove, Czech Republic

    *Purpose: The rate of thawing of cryopreserved human iliac arteries allografts (CHIAA) directly affects the severeness of structural changes that occur during this process. This…
  • 2019 American Transplant Congress

    Inhibition of Cyclin-Dependent Kinase 2 Signaling Prevents Liver Ischemia and Reperfusion Injury

    Z. Xue, J. Xu, C. Zhang, Y. Liu, R. Busuttil, J. Kupiec-Weglinski, H. Ji

    Dumont-UCLA Transplant Center, Los Angeles, CA

    *Purpose: Hepatic ischemia/reperfusion injury (IRI), an exogenous antigen-independent local inflammation response, occurs in multiple clinical settings including liver transplantation, hepatic resection, trauma, and shock. The…
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