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Articles tagged "Viral therapy"

  • 2018 American Transplant Congress

    An Individualized Strategy Using Virus and Immune-Based Markers to Prevent Cytomegalovirus Disease after Face Transplantation

    R. Razonable, H. Amer, S. Mardini.

    Mayo Clinic, Rochester, MN.

    Introduction: There is limited data on CMV prevention after face transplantation. We report an individualized approach using prophylaxis followed by surveillance and preemptive therapy guided…
  • 2018 American Transplant Congress

    Brincidofovir Was Used to Successfully Treat Adenovirus Infections in Solid Organ Transplant Recipients and Other Immunocompromised Patients

    D. Florescu,1 M. Grimley,2 G. Papanicolaou,3 V. Prasad,4 E. Vainorius,5 G. Chittick,5 T. Brundage,5 G. Nichols.5

    1Univ Nebraska Med Center, Omaha; 2Cincinnati Children's Hosp Center, Cincinnati; 3Memorial-Sloan Kettering Cancer Center, New York; 4Pediatric BMT, Duke Univ Med Center, Durham, NC; 5Chimerix, Inc., Durham.

    Background: Adenovirus (AdV) infections cause significant morbidity and mortality in immunocompromised patients. Brincidofovir (BCV) is an investigational antiviral drug with high in vitro potency against…
  • 2018 American Transplant Congress

    Antiviral Therapy for Donor-Derived Hepatitis C Virus Infection after Solid Organ Transplantation

    A. Kwong,1 A. Wall,2 M. Melcher,2 U. Wang,3 A. Ahmed,1 K. Khush,3 A. Subramanian,3 J. Tan,3 P. Kwo.1

    1Gastroenterology and Hepatology, Stanford University, Palo Alto, CA; 2Surgery, Stanford University, Palo Alto, CA; 3Stanford University, Palo Alto, CA.

    Background: In the context of organ shortage, the opioid epidemic, and the advent of effective direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV), more…
  • 2018 American Transplant Congress

    Early Adjunctive Treatment with Human Cytomegaly Virus (CMV) Immunoglobulin Increased CMV-Free Survival after Heart Transplantation

    M. Barten,1 C. Neumaier,1 A. Bernhardt,1 M. Rybczynski,2 R. Plaetke,3 H. Reichenspurner.1

    1Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany; 2General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; 3Institute of Medical Biometry and Epidemiology, University Hospital Eppendorf Hamburg, Hamburg, Germany.

    Purpose: There is still an ongoing discussion whether a prophylactic or a preemptive therapy against cytomegalovirus (CMV) is superior to reduce the incidence of CMV…
  • 2018 American Transplant Congress

    Once Daily CNI Administration Based on Pharmacodynamic Analysis for Preventing Viral Infection

    Y. Matsuoka,1 K. Iwasaki,2 Y. Miwa,2 K. Horimi,1 K. Uchida,2 T. Kobayashi.1

    1Renal Transplant Surgery, Aichi Medical University, Nagakute City, Aichi, Japan; 2Kidney Disease and Transplant Immunology, Aichi Medical University, Nagakute City, Aichi, Japan.

    BackgroundInfectious complications under immunosuppressive therapy are inevitable problems. Viral infection (include reactivation) occurs at a certain frequency even if immunosuppressive agents are totally adjusted by…
  • 2017 American Transplant Congress

    Impact of Timeliness of Assessment of Positive Cytomegalovirus Polymerase Chain Reaction Results in Abdominal Organ Transplant Recipients.

    K. Roach, H. Triemer, M. Hurtik, A. Mehta.

    Emory University Hospital, Atlanta, GA

    Purpose: The purpose of this study was to evaluate the timeliness of assessment of positive cytomegalovirus (CMV) polymerase chain reaction (PCR) results. This study served…
  • 2017 American Transplant Congress

    EXPANDER-1: Exploring Renal Transplants Using Hepatitis-C Infected Donors for HCV-Negative Recipients.

    C. Durand, D. Brown, R. Wesson, N. Bhair, F. Naqvi, D. Ostrander, M. Bowring, A. Massie, S. Rasmussen, J. Sugarman, D. Segev, M. Sulkowski, N. Desai.

    JHU, Baltimore, MD

    Kidneys from hepatitis C-infected (HCV+) donors are underutilized in an era of severe organ shortage. In an effort to expand the donor pool, we evaluated…
  • 2017 American Transplant Congress

    Reproducibility of the Cobas CMV Test (cobas CMV) and Clinical Concordance with the Cobas Ampliprep / Cobas TaqMan CMV Test (CAP/CTM CMV).

    P. Baum,1 J. Yao,2 A. Butcher,1 P. Hemyari,1 A. Valsamakis,3 S. Young.4

    1Roche Diagnostics, Pleasanton, CA; 2Mayo, Rochester, MN; 3JHMI, Baltimore, MD; 4Tricore, Albuquerque, NM

    cobas CMV is a new, automated, high-throughput assay for use on the cobas 6800/8800 systems that quantifies CMV DNA in EDTA-plasma. It can be run…
  • 2017 American Transplant Congress

    Contribution of New Generation Sequencing to CMV Resistance Analysis in Renal Transplant Recipients (on Behalf of the CMV Resist Group).

    C. Danthu,1 M. Gomes-Mayeras,1 D. Andouard,2 E. Munteanu,1 R. Moulinas,1,4 G. Ligat,2 S. Hantz,1,2 J. Rerolle,3 F. Garnier,1 M. Essig,3 S. Alain.1,2,4

    1National Reference Center for CMV-Virology, CHU Limoges, Limoges, France; 2UMR Inserm 1092, Université Limoges, Limoges, France; 3Nephrology, CHU Limoges, Limoges, France; 4GenoLim/Biscem Genomic Platform, Université Limoges, Limoges, France

    Results from the French Cohorts 2006-2010 and OrphaVic (NCTNCT02067169) indicates that fifty percent of graft failures in renal recipients infected by HCMV after treatment with…
  • 2017 American Transplant Congress

    Usefulness of Valacyclovir Prophylaxis for Preventing Cytomegalovirus Infection After Anti-Thymocyte Globulin Treatment as Antirejection Therapy.

    E. Ko,1,2 J. Yu,1,2 B. Choi,1,2 C. Park,1,2 Y. Kim,1,2 C. Yang,1,2 B. Chung.1,2

    1Transplant Research Center, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea; 2Division of Nephrology, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea

    Anti-thymocyte globulin (ATG) treatment for acute T-cell mediated rejection (TCMR) can increase the risk of CMV infection. We purposed to evaluate the effect of valacyclovir…
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