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Articles tagged "Viral therapy"

  • 2019 American Transplant Congress

    Experience With Letermovir Use For The Management Of Cytomegalovirus In Solid Organ Transplant Recipients

    J. L. Orejas1, F. M. Marty1, A. M. McDonnell2, M. P. Cheng1, E. Arbona-Haddad1, S. P. Hammond1, S. Koo1

    1Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, 2Department of Pharmacy, Brigham and Women's Hospital, Boston, MA

    *Purpose: Letermovir is a new antiviral recently approved for cytomegalovirus (CMV) prophylaxis in CMV-seropositive hematopoietic-cell transplant recipients. Its off-label use in solid organ transplant (SOT)…
  • 2018 American Transplant Congress

    Brincidofovir Was Used to Successfully Treat Adenovirus Infections in Solid Organ Transplant Recipients and Other Immunocompromised Patients

    D. Florescu,1 M. Grimley,2 G. Papanicolaou,3 V. Prasad,4 E. Vainorius,5 G. Chittick,5 T. Brundage,5 G. Nichols.5

    1Univ Nebraska Med Center, Omaha; 2Cincinnati Children's Hosp Center, Cincinnati; 3Memorial-Sloan Kettering Cancer Center, New York; 4Pediatric BMT, Duke Univ Med Center, Durham, NC; 5Chimerix, Inc., Durham.

    Background: Adenovirus (AdV) infections cause significant morbidity and mortality in immunocompromised patients. Brincidofovir (BCV) is an investigational antiviral drug with high in vitro potency against…
  • 2018 American Transplant Congress

    Antiviral Therapy for Donor-Derived Hepatitis C Virus Infection after Solid Organ Transplantation

    A. Kwong,1 A. Wall,2 M. Melcher,2 U. Wang,3 A. Ahmed,1 K. Khush,3 A. Subramanian,3 J. Tan,3 P. Kwo.1

    1Gastroenterology and Hepatology, Stanford University, Palo Alto, CA; 2Surgery, Stanford University, Palo Alto, CA; 3Stanford University, Palo Alto, CA.

    Background: In the context of organ shortage, the opioid epidemic, and the advent of effective direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV), more…
  • 2018 American Transplant Congress

    Early Adjunctive Treatment with Human Cytomegaly Virus (CMV) Immunoglobulin Increased CMV-Free Survival after Heart Transplantation

    M. Barten,1 C. Neumaier,1 A. Bernhardt,1 M. Rybczynski,2 R. Plaetke,3 H. Reichenspurner.1

    1Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany; 2General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; 3Institute of Medical Biometry and Epidemiology, University Hospital Eppendorf Hamburg, Hamburg, Germany.

    Purpose: There is still an ongoing discussion whether a prophylactic or a preemptive therapy against cytomegalovirus (CMV) is superior to reduce the incidence of CMV…
  • 2018 American Transplant Congress

    Once Daily CNI Administration Based on Pharmacodynamic Analysis for Preventing Viral Infection

    Y. Matsuoka,1 K. Iwasaki,2 Y. Miwa,2 K. Horimi,1 K. Uchida,2 T. Kobayashi.1

    1Renal Transplant Surgery, Aichi Medical University, Nagakute City, Aichi, Japan; 2Kidney Disease and Transplant Immunology, Aichi Medical University, Nagakute City, Aichi, Japan.

    BackgroundInfectious complications under immunosuppressive therapy are inevitable problems. Viral infection (include reactivation) occurs at a certain frequency even if immunosuppressive agents are totally adjusted by…
  • 2018 American Transplant Congress

    Cytomegalovirus Infection in Pediatric Solid Organ Transplant Recipients and Role of Prophylaxis

    G. Nance,1 A. Serluco,1 S. Deshpande,2,1 R. Garro,3,1 R. George,3,1 M. Kelleman,3 R. Liverman.1

    1Children's Healthcare of Atlanta, Atlanta, GA; 2Sibley Heart Center Cardiology, Atlanta, GA; 3Emory University, Atlanta, GA.

    Objectives: Cytomegalovirus (CMV) is an opportunistic infection that can lead to significant complications post-transplant. Purpose of this study was to evaluate the use of valganciclovir…
  • 2018 American Transplant Congress

    Val-Ganciclovir Prophylaxis Delays Onset of EBV Viremia in the First Year Post-Solid Organ Transplantation in High-Risk Patients

    S. Albatati,1 A. Sharma,2 S. Gantt,1 K. Haubrich,1 A. Wright,1 T. Blydt-Hansen.1

    1University of British Columbia, Vancouver, Canada; 2University of Manitoba, Winnipeg, Canada.

    Introduction: Donor-derived primary Epstein-Barr virus (EBV) infection poses serious risks to EBV naïve children post-solid organ transplantation, including development of EBV-related PTLD. Currently, there is…
  • 2018 American Transplant Congress

    Efficacy of Generic Sofosbuvir and Branded Daclatasvir Compared to Sofosbuvir and Ledipasvir Combination in the Treatment of Genotype 4 Hepatitis C Virus

    H. Joharji, A. Al-Jedai, D. Alkortas, A. Ajlan, E. Devol, M. Ahmed, F. Aba Al-Khail, H. El-Siesy, M. Al-Sebayel, H. Al-Ashgar, M. Al-Quaiz, W. Alhomodi, A. Aloubal, A. Almohishir.

    King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.

    Genotype 4 HCV is the most common genotype in Saudi Arabia and the Middle East. Management of genotype 4 HCV has shifted to interferon free…
  • 2018 American Transplant Congress

    Effect of Direct-Acting Hepatitis C Treatment Regimens on Calcineurin Inhibitors in Liver and Kidney Transplant Patients

    M. Laub, J. Byrns, M. Harris, C. Berg, S. Sanoff.

    Duke University Hospital, Durham, NC.

    Background: It has been suggested that treatment with direct-acting antivirals (DAA) for hepatitis C virus (HCV) may decrease calcineurin inhibitor (CNI) concentrations. The purpose of…
  • 2018 American Transplant Congress

    Building a Third-Party VST Bank from Scratch- The Cincinnati Experience

    A. S. Nelson,1 D. Heyenbruch,2 X. Zhu,3 S. M. Davies,1 C. Lutzko,3 C. Bollard,4 P. Hanley,4 T. Leemhuis,2 L. Danziger-Isakov,5 M. S. Grimley.1

    1Bone Marrow Transplant & Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; 2Hoxworth Blood Center, Univeristy of Cincinnati, Cincinnati, OH; 3Experimental Hematology & Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; 4Proram for Cell Enhancement and Technologies for Immunotherapy, Children's National Health System, Washington, DC; 5Depatment of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

    BackgroundViral infections remain a challenge to treat and significantly contribute to morbidity and mortality. Virus specific T cells (VSTs) have shown clinical efficacy, with minimal…
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