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American Transplant Congress abstracts

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Articles tagged "Viral therapy"

  • 2019 American Transplant Congress

    Reduction in Waitlist Time Using HCV Positive Liver Grafts in HCV Negative Recipients

    E. M. Bugeaud, N. Bzowej, J. Hand, J. Scheuermann, H. Bohorquez, C. Brown, D. Bruce, I. Carmody, A. Cohen, S. Joshi, N. Latt, J. Seal, D. Sonnier, G. Therapondos, G. Tyson, N. Girgrah, G. Loss

    Ochsner Health System, New Orleans, LA

    *Purpose: With direct-acting antiviral (DAA) therapy, we feel that HCV+ organs are safe for all patients regardless of their HCV status and have adopted a…
  • 2018 American Transplant Congress

    Impact of Direct Acting Antivirals of Hepatitis C Virus Therapy on Tacrolimus Dosing Post-Liver Transplant

    A. Bixby, L. Fitzgerald, R. Leek, J. Mellinger, S. Tischer.

    Michigan Medicine, Ann Arbor, MI.

    Background: Direct acting antivirals (DAA) have transformed hepatitis C virus (HCV) management post-liver transplant (LT). As HCV clears, hepatic metabolism improves, resulting in decreased tacrolimus…
  • 2018 American Transplant Congress

    Direct-Acting Antiviral Therapy Immune-Mediated Graft Dysfunction in Liver Transplant Recipients with Hepatitis C

    C. Chan,1 E. Agudelo,2 J. Haydek,3 M. Hoteit,4 M. Laurito,5 J. Norvell,3 T. Schiano,6 N. Terrault,2 E. Verna,5 A. Yang,1 J. Levitsky.1

    1Northwestern University, Chicago, IL; 2UCSF, San Francisco, CA; 3Emory University, Atl, GA; 4University of Pennsylvania, Philadelphia, PA; 5Columbia University, NY, NY; 6Mount Sinai, NY, NY.

    Background and Aims:Interferon (IFN) treatment of hepatitis C virus (HCV) infection after liver transplantation (LT) can result in severe immune-mediated graft dysfunction (IGD). The occurrence…
  • 2018 American Transplant Congress

    Incidence of Acute Cellular Rejection in Liver Transplant Patients Receiving Direct Acting Antivirals for Hepatitis C Treatment

    D. Bley,1 L. Sagardia,1 R. Ford,2 S. Todd.1

    1Pharmacy, Emory University Hospital, Atlanta, GA; 2School of Medicine, Emory University, Atlanta, GA.

    Direct acting antivirals (DAAs) have been used for the treatment of hepatitis C (HCV) in liver transplant patients since early on after their approval, however…
  • 2018 American Transplant Congress

    An Individualized Strategy Using Virus and Immune-Based Markers to Prevent Cytomegalovirus Disease after Face Transplantation

    R. Razonable, H. Amer, S. Mardini.

    Mayo Clinic, Rochester, MN.

    Introduction: There is limited data on CMV prevention after face transplantation. We report an individualized approach using prophylaxis followed by surveillance and preemptive therapy guided…
  • 2018 American Transplant Congress

    Brincidofovir Was Used to Successfully Treat Adenovirus Infections in Solid Organ Transplant Recipients and Other Immunocompromised Patients

    D. Florescu,1 M. Grimley,2 G. Papanicolaou,3 V. Prasad,4 E. Vainorius,5 G. Chittick,5 T. Brundage,5 G. Nichols.5

    1Univ Nebraska Med Center, Omaha; 2Cincinnati Children's Hosp Center, Cincinnati; 3Memorial-Sloan Kettering Cancer Center, New York; 4Pediatric BMT, Duke Univ Med Center, Durham, NC; 5Chimerix, Inc., Durham.

    Background: Adenovirus (AdV) infections cause significant morbidity and mortality in immunocompromised patients. Brincidofovir (BCV) is an investigational antiviral drug with high in vitro potency against…
  • 2018 American Transplant Congress

    Antiviral Therapy for Donor-Derived Hepatitis C Virus Infection after Solid Organ Transplantation

    A. Kwong,1 A. Wall,2 M. Melcher,2 U. Wang,3 A. Ahmed,1 K. Khush,3 A. Subramanian,3 J. Tan,3 P. Kwo.1

    1Gastroenterology and Hepatology, Stanford University, Palo Alto, CA; 2Surgery, Stanford University, Palo Alto, CA; 3Stanford University, Palo Alto, CA.

    Background: In the context of organ shortage, the opioid epidemic, and the advent of effective direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV), more…
  • 2018 American Transplant Congress

    Early Adjunctive Treatment with Human Cytomegaly Virus (CMV) Immunoglobulin Increased CMV-Free Survival after Heart Transplantation

    M. Barten,1 C. Neumaier,1 A. Bernhardt,1 M. Rybczynski,2 R. Plaetke,3 H. Reichenspurner.1

    1Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany; 2General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; 3Institute of Medical Biometry and Epidemiology, University Hospital Eppendorf Hamburg, Hamburg, Germany.

    Purpose: There is still an ongoing discussion whether a prophylactic or a preemptive therapy against cytomegalovirus (CMV) is superior to reduce the incidence of CMV…
  • 2018 American Transplant Congress

    Once Daily CNI Administration Based on Pharmacodynamic Analysis for Preventing Viral Infection

    Y. Matsuoka,1 K. Iwasaki,2 Y. Miwa,2 K. Horimi,1 K. Uchida,2 T. Kobayashi.1

    1Renal Transplant Surgery, Aichi Medical University, Nagakute City, Aichi, Japan; 2Kidney Disease and Transplant Immunology, Aichi Medical University, Nagakute City, Aichi, Japan.

    BackgroundInfectious complications under immunosuppressive therapy are inevitable problems. Viral infection (include reactivation) occurs at a certain frequency even if immunosuppressive agents are totally adjusted by…
  • 2018 American Transplant Congress

    Cytomegalovirus Infection in Pediatric Solid Organ Transplant Recipients and Role of Prophylaxis

    G. Nance,1 A. Serluco,1 S. Deshpande,2,1 R. Garro,3,1 R. George,3,1 M. Kelleman,3 R. Liverman.1

    1Children's Healthcare of Atlanta, Atlanta, GA; 2Sibley Heart Center Cardiology, Atlanta, GA; 3Emory University, Atlanta, GA.

    Objectives: Cytomegalovirus (CMV) is an opportunistic infection that can lead to significant complications post-transplant. Purpose of this study was to evaluate the use of valganciclovir…
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