Articles tagged "Viral therapy"

2021 American Transplant Congress
Evaluation of Low Dose Famciclovir as Herpes Simplex Virus and Varicella Zoster Virus Prophylaxis in Cytomegalovirus Low Risk Solid Organ Transplant Recipients
M. Cote, A. Cubley, C. Rogers, S. Shao, C. N. Kotton
Massachusetts General Hospital, Boston, MA
*Purpose: Famciclovir is recommended for herpes simplex virus (HSV) and varicella-zoster virus (VZV) prophylaxis in cytomegalovirus (CMV) low risk (both donor and recipient CMV seronegative)…
2021 American Transplant Congress
Clinical Outcomes and Management of Covid-19 Patients Among Kidney Transplant Recipients: A Systematic Review
S. Ismail¹, A. Babonj², S. Al Harbi³, A. Babonj², A. Almalki¹, E. J. Murray⁴
¹King Khalid hospital, MNGHA, Jeddah, Saudi Arabia, ²King Abdulaziz University, Jeddah, Saudi Arabia, ³King Faisal Specialist Hospital, Jeddah, Saudi Arabia, ⁴Boston University School of Public Health, Boston, MA
*Purpose: We aim to systematically review published literature and synthesize the evidence available on therapeutic interventions and clinical outcomes used in the management of COVID-19…
2021 American Transplant Congress
Real-world Treatment Patterns of Antiviral Agents for Cytomegalovirus Among Adult Kidney Transplant Recipients: A USRDS-Medicare Linked Database Study
A. D. Raval¹, M. Ganz², P. Saravanan², Y. Tang¹, C. A. Santos³
¹Merck & Co., Inc., Kenilworth, NJ, ²Evidera, Inc., Waltham, MA, ³Rush University Medical Center, Chicago, IL
*Purpose: Cytomegalovirus (CMV) is a common viral pathogen among kidney transplant recipients (KTRs). Although guidelines recommend the use of prophylaxis or pre-emptive antiviral (AV) therapy…
2021 American Transplant Congress
Impact of Cytomegalovirus Prophylaxis on Herpes Simplex and Varicella Zoster Virus Infections in Kidney Transplant Recipients
K. Ridgely¹, B. Crowther², P. Klem², K. Schoeppler¹, K. Schwarz¹, A. Nadrash², V. Lewis¹, E. Benamu³
¹Department of Pharmacy Services, UCHealth University of Colorado Hospital, Aurora, CO, ²Ambulatory Care Pharmacy Services, UCHealth University of Colorado Hospital, Aurora, CO, ³Department of Medicine, UCHealth University of Colorado Hospital, Aurora, CO
*Purpose: To assess the impact of cytomegalovirus (CMV) targeted antiviral prophylaxis on the development of herpes simplex (HSV) and varicella zoster (VZV) infections after kidney…
2021 American Transplant Congress
Clinical Outcomes of Solid Organ Transplant Recipients Treated with Remdesivir and Convalescent Plasma for Covid-19 at the Largest Transplant Center in the United States
A. Fernandez, S. Anjan, A. Chandorkar, D. de Lima, R. Zamora, L. A. Mendez-Castaner, J. Simkins, J. Camargo, M. Morris, M. Loebe, J. Bauerlein, C. O’Brien, N. Sinha, G. Burke, G. Ciancio, A. Mattiazzi, R. Vianna, L. Abbo, G. Guerra, Y. Natori
Miami Transplant Institute, Jackson Health System, Miami, FL
*Purpose: Solid organ transplant recipients (SOTr) are at high risk for severe disease with SARS-CoV-2. Data on efficacy of potential treatment options and long-term outcomes…
2021 American Transplant Congress
Longitudinal Antibody Response and Viral Loads in Covid-infected Organ Transplant Recipients
T. M. Marinelli, V. H. Ferreira, M. Ierullo, V. Kulasingham, B. Majchrzak-Kita, C. Rotstein, S. Husain, S. Hosseini, A. Humar, D. Kumar
UHN, Toronto, ON, Canada
*Purpose: The full spectrum of COVID-19 disease and the impact of disease severity on antibody response and viral shedding dynamics in transplant patients is unclear.…
2021 American Transplant Congress
Leflunomide Therapy for Treatment of Bk Viremia in Pediatric Kidney Transplant Recipients
A. Aldieri¹, M. Chandran², D. Matossian³, B. Magella⁴, D. Lazear⁴, M. Bock², E. Blanchette²
¹Children's Hospital Colorado, Denver, CO, ²Children's Hospital Colorado, Aurora, CO, ³Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁴Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: BK viremia (BKV) after kidney transplantation (KT) poses significant risk for BK virus-associated nephropathy (BKVN) and impacts graft survival. Conventional treatment involves reduction of…
2021 American Transplant Congress
Influence of Induction Therapy and Antiretroviral Regimen on Outcomes in HIV Positive Renal Transplant Recipients
C. Rogers Marks¹, C. Durand², J. Hand³, M. Abidi⁴, M. Malinis⁵, B. Barnaba², H. Patel⁶, C. D. Alonso⁶
¹Massachussetts General Hospital, Boston, MA, ²Johns Hopkins Medical Center, Baltimore, MD, ³Ochsner Medical Center, New Orleans, LA, ⁴Univ. of Colorado, Aurora, CO, ⁵Yale, New Haven, CT, ⁶Beth Israel Deaconess Medical Center, Boston, MA
*Purpose: Transplantation of HIV+ individuals has become more common over the past decade with increasing data supporting good outcomes. Questions remain regarding the impact of…
2021 American Transplant Congress
Monoclonal Antibody Therapy for COVID-19 in Solid Organ Transplant Recipients
Z. A. Yetmar¹, E. Beam¹, J. C. O'Horo¹, R. Ganesh², D. M. Bierle², L. Brumble³, M. T. Seville⁴, R. R. Razonable¹
¹Infectious Diseases, Mayo Clinic, Rochester, MN, ²General Internal Medicine, Mayo Clinic, Rochester, MN, ³Infectious Diseases, Mayo Clinic, Jacksonville, FL, ⁴Infectious Diseases, Mayo Clinic, Scottsdale, AZ
*Purpose: Bamlanivimab and casirivimab-imdevimab are authorized for emergency use treatment of mild-to-moderate COVID-19 in patients at high-risk for progression to severe disease or hospitalization. For…
2021 American Transplant Congress
Outcomes of Short-Duration Anti-Viral Prophylaxis for Hepatitis C Positive Donor Kidney Transplants
G. Gupta, I. Yakubu, P. Kimball, L. Kang, K. Mitchell, M. Shinbashi, D. Kumar, I. Moinuddin, L. Kamal, A. King, C. Bhati, M. Levy, A. Cotterell, A. Sharma, R. Sterling
Virginia Commonwealth University Health System, Richmond, VA
*Purpose: Trials describing 4-12 week courses of direct-acting anti-viral drugs (DAAs) to treat hepatitis C virus (HCV) transmission from infected donors to uninfected kidney transplant…