ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Viral therapy"

  • 2017 American Transplant Congress

    Can Viral Load Be Used as a Surrogate Marker in Clinical Studies of Cytomegalovirus in Solid Organ Transplantation: A Systematic Review and Metaanalysis.

    Y. Natori,1 A. Alghamdi,1 D. Kumar,1 V. Miller,2 P. Ljungman,3 S. Husain,1 A. Humar.1

    1Multi-Organ Transplant Program, UHN, Toronto, Canada; 2UC-Berkeley, Berkeley; 3Karolinska Inst., Solna, Sweden

    Background: Regulatory trials assessing CMV drugs have utilized symptomatic CMV disease as the primary endpoint. However CMV disease occurs infrequently, CMV syndrome is nonspecific, and…
  • 2017 American Transplant Congress

    Generation of Autologous CMV and EBV-Specific T-Cell Lines from Seronegative Patients for Cell Therapy of Opportunistic Infections Following Kidney Transplantation.

    C. Lamarche,1 T. Pincez,1 J. Orio,1 C. Carli,1 A. Humar,2 J.-S. Delisle.1

    1Centre de Recherche de l'Hôpital Maisonneuve-Rosemont, Montreal, QC, Canada; 2Toronto General Research Institute, Toronto, ON, Canada

    Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) reactivations after kidney transplant are associated with substantial morbidity, especially in seronegative patients. Adoptive immunotherapy using virus-specific T cells…
  • 2017 American Transplant Congress

    Assessment of Attitudes Toward Use of Hepatitis C Positive Liver Allografts in US Transplant Centers.

    S. Kilaru,1 E. Tapper,2 M. Curry.3

    1Medicine, NYU School of Medicine, New York, NY; 2Medicine, University of Michigan, Ann Arbor, MI; 3Medicine, Beth Israel Deaconess Medical Center, Boston, MA

    Background:Direct-acting antivirals (DAAs) have been shown to have high cure rates in hepatitis C (HCV)-positive liver transplantation (LT) recipients. The organ donor shortage has led…
  • 2017 American Transplant Congress

    Evaluation of Low Dose Valganciclovir for the Prevention of Cytomegalovirus in Liver Transplant Recipients.

    C. Payne,1 J. Melaragno,1 D. Hutchinson,1 T. Babu,2 P. Prasad,2,3 T. Dick.1

    1Pharmacy, University of Rochester Medical Center, Rochester, NY; 2Division of Infectious Diseases, University of Rochester Medical Center, Rochester, NY; 3Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, Rochester, NY

    BACKGROUND: Cytomegalovirus (CMV) causes significant morbidity and mortality following orthotopic liver transplantation (OLT). Valganciclovir (VGCV) is used to prevent CMV, but at labeled doses can…
  • 2017 American Transplant Congress

    Impact of Ritonavir on Graft Function in Human Immunodeficiency Virus Infected Kidney Transplant Recipients.

    K. Roach, E. Meredith, M. Lyon.

    Emory University Hospital, Atlanta, GA

    Purpose: The purpose of this study was to determine the difference in 6 and 12 month graft function between patients with human immunodeficiency virus (HIV)…
  • 2017 American Transplant Congress

    Tenofovir Use Is Not Associated with Reduced Bone Density or Fractures in Liver Transplant Recipients.

    N. Lim, C. Engler, J. Lake.

    University of Minnesota, Minneapolis, MN

    BackgroundTenofovir disproxil fumarate (TDF) and reduced bone density in the HIV population is well-documented. The effect of TDF use on bone density in patients who…
  • 2017 American Transplant Congress

    Influenza Viral Dynamics in a Large Cohort of Transplant Patients with Natural Influenza Infection.

    V. Ferreira,1 A. Humar,1 E. Cordero,2 E. Blumberg,3 A. Limaye,8 F. Silveira,5 L. Danziger-Isakov,6 M. Levi,7 J. Kalpoe,4 J. Englund,9 M. Multicenter Influenza Group, D. Kumar.1

    1UHN, Toronto, Canada; 2REIPI, Seville, Spain; 3UPenn, Philadelphia; 4LUMC, Leiden, Netherlands; 5UPMC, Pittsburgh; 6CCHMC, Cincinnati; 7UCD, Denver; 8UW, Seattle; 9SCH, Seattle

    Background:Influenza infection significantly impacts transplant patients. Despite this, there are limited data on how virological characteristics, including influenza viral load (VL), impact the outcome of…
  • 2017 American Transplant Congress

    A Single Center's Experience of Direct Acting Anti-Viral Agents in HCV Positive Patients Receiving an HCV Positive Kidney.

    N. Kapila,1 B. Zervos,2 B. Ismail,1 G. Schnickel,2 J. Rivas,2 D. Reino,2 N. Agrawal,2 A. Tzakis.2

    1Gastroenterology/Hepatology, Cleveland Clinic, Weston, FL; 2Transplant, Cleveland Clinic, Weston, FL

    Background: Nearly 8% of patients in the U.S. undergoing hemodialysis are Hepatitis C (HCV) positive. There is a survival benefit in HCV positive patients who…
  • 2017 American Transplant Congress

    Mutations in Influenza A Virus and Clinical Implications in Transplant Recipients.

    V. Ferreira,1 A. Humar,1 E. Cordero,2 E. Blumberg,3 S. Husain,1 J. Kalpoe,4 M. Multicenter Influenza Group, D. Kumar.1

    1UHN, Toronto, Canada; 2REIPI, Seville, Spain; 3UPenn, Philadelphia; 4LUMC, Leiden, Netherlands

    Background: Organ and hematopoietic stem cell transplant (HSCT) recipients are predisposed to complications of influenza infection and as such may constitute an important source of…
  • 2017 American Transplant Congress

    Hepatitis E Virus-Associated Cryoglobulinemia in Solid-Organ-Transplant Recipients: A Prospective Study.

    O. Marion,1 F. Abravanel,2 L. Esposito,1 S. Lhomme,2 A. Del Bello,1 J. Izopet,2 N. Kamar.1

    1Nephrology and Organ Transplant Unit, CHU Rangueil, Toulouse, France; 2Laboratory of Virology, CHU Purpan, Toulouse, France

    Hepatitis E virus (HEV) is responsible for acute and chronic autochthonous hepatitis in developed countries, particularly in Western Europe. Conversely to hepatitis B or C,…
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