ATC Abstracts

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Articles tagged "Viral therapy"

  • 2022 American Transplant Congress

    Evaluation of the Management of Cytomegalovirus in Kidney Transplant Recipients After Establishment of a Multidisciplinary Cytomegalovirus Workgroup

    A. Boyle, A. Spenningsby, H. Rhodes, T. Anderson-Haag

    Hennepin County Medical Center, Minneapolis, MN

    *Purpose: To assess the effectiveness of a multidisciplinary cytomegalovirus (CMV) workgroup in managing CMV in kidney transplant recipients.*Methods: Retrospective chart review at a single transplant…
  • 2022 American Transplant Congress

    Ultra-Short Duration Prophylaxis for Hepatitis C Donor Positive to Recipient Negative Simultaneous Kidney/Pancreas Transplants

    G. Gupta, I. Yakubu, A. Khan, R. Sterling

    Virginia Commonwealth University, Richmond, VA

    *Purpose: Recent trials have successfully utilized a strategy of hepatitis C virus (HCV) D+ [Donor nucleic acid test (NAT) positive]/R- (Recipient NAT negative) kidney and/or…
  • 2022 American Transplant Congress

    Preemptive  Therapy for Cytomegalovirus (CMV) Disease Prevention in High-Risk CMV Donor Seropositive Recipient Seronegative (D+/R-) Liver Transplant Recipients in a Real-World Setting 

    K. M. Doss1, C. Kling1, M. R. Heldman1, N. Singh2, M. Wagener3, C. E. Fisher1, A. Limaye1

    1University of Washington, Seattle, WA, 2University of Pittsburgh, PIttsburgh, PA, 3University of Pittsburgh, Pittsburgh, PA

    *Purpose:  Preemptive therapy  (PET)  has  demonstrated superiority to antiviral prophylaxis  for  prevention of  cytomegalovirus (CMV)  disease  in  CMV  donor seropositive/recipient seronegative (D+R-)  liver transplant recipients …
  • 2022 American Transplant Congress

    Use of Targeted T-Cell Therapy (Posoleucel) for the Treatment of Epstein-Barr Virus Associated Leiomyosarcoma in an Adult Kidney Transplant Recipient: A Case Report

    R. Saranu1, S. Nikiforow2, V. Jo3, H. So2, P. Stowe2, S. Tripathi1, F. Cardarelli4, A. Chandraker1

    1Renal Division, Brigham and Women's Hospital, Boston, MA, 2Dana Farber Cancer Institute, Boston, MA, 3Pathology, Brigham and Women's Hospital, Boston, MA, 4Allovir, Cambridge, MA

    *Purpose: Epstein-Barr virus (EBV)-associated leiomyosarcomas (EBV+LMS) are neoplasms rarely seen in solid organ transplant (SOT) recipients and currently lack effective treatment options. We present a…
  • 2022 American Transplant Congress

    Impact of Dysgeusia on Transplant Recipients with Refractory Cytomegalovirus with/without Resistance Receiving Maribavir: Post-Hoc Analyses from a Phase 3 Randomized Trial

    F. Silveira1, S. Haider2, D. Kaul3, O. Witzke4, J. Gu5, A. Sundberg5

    1Univ. Pittsburgh, Pittsburgh, PA, 2McMaster Univ., Hamilton, ON, Canada, 3Univ. Michigan, Ann Arbor, MI, 4Univ. Duisburg-Essen, Essen, Germany, 5Takeda Development Center Americas, Inc., Lexington, MA

    *Purpose: In a Phase 3 study (SOLSTICE; NCT02931539), maribavir (MBV) was superior to investigator-assigned therapies (IAT; val/ganciclovir, foscarnet, or cidofovir) for CMV clearance at Wk…
  • 2022 American Transplant Congress

    Immunoglobulin M (IgM) Inhibits Replication of SARS-CoV-2 In Vero E6 Cells In Vitro and Delays Disease in K18-hACE2 Mice Infected with SARSCoV-2 In Vivo

    P. Chhabra1, B. Mann2, M. Ma1, S. Feldman3, K. L. Brayman1

    1Department of Surgery, University of Virginia Health System, Charlottesville, VA, 2Department of Infectious Diseases, University of Virginia Health System, Charlottesville, VA, 3Center for Comparative Medicine, University of Virginia Health System, Charlottesville, VA

    *Purpose: To determine if IgM has a direct effect in preventing SARS-CoV-2 replication in Vero E6 cells, and delaying or preventing disease in infected K18-hACE2…
  • 2022 American Transplant Congress

    Adenosine A2A Receptor (A2AR) Agonist Apadenoson Promotes Survival in K28-hACE2 Mice and Syrian Hamsters Infected with Sars-CoV-2

    P. Chhabra1, B. Mann2, M. Ma1, S. Feldman3, J. Linden4, K. L. Brayman1

    1Department of Surgery, University of Virginia Health System, Charlottesville, VA, 2Department of Infectious Diseases, University of Virginia Health System, Charlottesville, VA, 3Center for Comparative Medicine, University of Virginia Health System, Charlottesville, VA, 4Department of Nephrology, University of Virginia Health System, Charlottesville, VA

    *Purpose: To determine if Apadenoson or Regadenoson has a therapeutic effect in attenuating hyper-inflammation and improving survival rate in K18-hACE2mice or Syrian hamsters infected with…
  • 2022 American Transplant Congress

    Metagenomic Next-Generation Sequencing Reveals the Profile of Viral Infections in Kidney Transplant Recipients During the Covid-19 Pandemic

    X. Tian, W. Duan, C. Zhang, X. Wu, T. Yan

    Henan Province People's Hospital, Zhengzhou, Henan Province, China

    *Purpose: To study the clinical application of metagenomic next-generation sequencing (mNGS) in the detection of viral infections in kidney transplant recipients (KTRs) during the COVID-19…
  • 2022 American Transplant Congress

    Management of Hepatitis B Positive Donors in Liver Transplant

    M. Tilley1, T. A. Sparkman2, K. Gutierrez2

    1Pharmacy, UAB, Birmingham, AL, 2UAB, Birmingham, AL

    *Purpose: In an effort to expand the pool of solid organ transplant donors, patients with end stage liver disease may receive an organ from a…
  • 2022 American Transplant Congress

    Transplantation of Hepatitis C Viremic Donor Organs to Hepatitis C Nonviremic Recipients: A Retrospective Review

    M. Leick, M. Blaha, M. Henry

    Nebraska Medicine, Omaha, NE

    *Purpose: The advent of combination direct-acting antiviral (DAA) agents has improved the ability to treat hepatitis C virus (HCV) infections. As a result, utilization of…
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