Articles tagged "Vascular disease"

2017 American Transplant Congress
HLA, ANA, and ANCA Negative Vasculitis in Lung Transplantation Due to Overexpression of α1 Collagen V.
E. Daoud,¹ Y. Butt,¹ F. Torres,² T. Jose.¹
¹Pathology, University of Texas Southwestern Medical Center, Dallas, TX; ²Lung Transplant Program, University of Texas Southwestern Medical Center, Dallas, TX
The mechanism of fibrosing vasculopathy in lung allograft is poorly understood. A 58 year old man received a bilateral lung transplant for interstitial lung disease.…
2017 American Transplant Congress
Transcatheter Relief of Symptomatic Hepatic Venous Outflow Obstruction Following Pediatric Liver Transplantation.
B. Goldstein, G. Tiao, M. Alonso, N. Johnson, J. Heubi, K. Averin, J. Bucuvalas.
Cincinnati Children's Hospital, Cincinnati, OH
Background: Technical-variant allograft (TVA) pediatric liver transplantation (LT) is associated with vascular complications. Early recognition and treatment of hepatic venous outflow obstruction (HVOO) may be…
2017 American Transplant Congress
Association Between Matrix-gla Protein Levels and Aortic Stiffness in Kidney Transplantation.
M. Dinic,¹ N. Maillard,¹ P. Delanaye,² J.-M. Krzesinski,² A.-M. Saint-Remy,² E. Cavalier,³ C. Mariat.¹
¹Nephrology, Dialysis and Renal Transplantation, CHU Nord, Saint Etienne, France; ²Nephrology and Dialysis, University of Liège, CHU Sart Tilman, Liège, Belgium; ³Clinical Chemistry, University of Liège, CHU Sart Tilman, Liège, Belgium
INTRODUCTIONAortic stiffness due to vascular calcifications is commonly observed among kidney transplant recipients and is considered as a predictive factor of poor events such as…
2017 American Transplant Congress
Renal Function, Albuminuria, and the Risk of Cardiovascular Events After Kidney Transplantation.
N. Lam,¹ M. Tonelli,² K. Lentine,³ B. Hemmelgarn,² F. Ye,¹ A. Bello,¹ S. Klarenbach.¹
¹University of Alberta, Edmonton, Canada; ²University of Calgary, Calgary, Canada; ³Saint Louis University, St. Louis
The risk of mortality and graft loss is higher in kidney transplant recipients with reduced estimated glomerular filtration rate (eGFR) and heavier albuminuria. It is…
2016 American Transplant Congress
The 20S Proteasome, Active within Exosome-Like Vesicles Released by Apoptotic Cells Accelerates Rejection.
M. Dieudé,^1,4,5 C. Bell,^2,5 J. Turgeon,^1,5 D. Beillevaire,^1,4,5 S. Qi,^1,5 E. Boilard,^3,5 P. Thibault,^2,5 M.-J. Hébert.^1,4,5
¹Research Centre Centre hospitalier de l'Université de Montréal (CRCHUM), Montréal, Canada; ²Institute for research in immunology and cancer (IRIC), Montreal, Canada; ³Centre de Recherche du CHU de Québec, Québec, Canada; ⁴Université de Montréal, Montréal, Canada; ⁵Canadian National Transplant Research Program, Edmonton, Canada.
Apoptotic bodies (ApoBodies) and apoptotic exosome-like MV (ApoExo) released by apoptotic endothelial cells in vitro were purified by sequential centrifugation and analysed by electron microscopy…
2016 American Transplant Congress
Prevalence of Polyreactive Innate-Like B Cells Among Graft-Infiltrating B Cells in Human Cardiac Allograft Vasculopathy.
D. Chatterjee,¹ C. Moore,² B. Gao,³ K. Clerkin,¹ S. See,¹ D. Shaked,¹ K. Rogers,¹ S. Nunez,¹ Y. Veras,¹ L. Addonizio,¹ M. Givertz,⁴ Y. Naka,¹ D. Mancini,¹ R. Vasilescu,⁵ C. Marboe,⁵ S. Restaino,¹ J. Madsen,² E. Zorn.¹
¹Medicine, Columbia University Medical Center, NY, NY; ²Massachusetts General Hospital Transplant Center, Boston; ³First Hospital of Jilin University, Changchun, China; ⁴Brigham and Women's Hospital, Boston; ⁵Pathology & Cell Biology, Columbia University Medical Center, NY.
Cardiac allograft vasculopathy (CAV) is a leading cause of death in long-term heart transplant survivors. Dense B cell infiltrates are common in heart transplants with…
2016 American Transplant Congress
Pre-Transplant Cardiovascular Risk Factors Affect Kidney Allograft Survival: A Multi-Center Study in Korea.
J. An,^1,2 S. Ahn,³ E. Bae,² E. Kang,² H.-L. Kim,⁴ Y.-J. Kim,⁵ Y. Oh,^1,2 C. Lim,^1,2 Y. Kim,² Y. Kim,⁶ J. Lee.^1,2
¹Division of Nephrology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea; ²Division of Nephrology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; ³Department of Preventive Medicine, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do, Korea; ⁴Division of Cardiology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea; ⁵Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; ⁶Department of Surgery, Asan Medical Center and University of Ulsan College of Medicine, Seoul, Korea.
Background - Pre- or post-transplant cardiovascular (CV) risk factors affect the development of CV events even after successful kidney transplantation (KT). However, the impact of…
2016 American Transplant Congress
Outcomes of EVAR in Kidney Transplant Recipients: Results form a National Quality Initiative.
I. Bostock,¹ D. Zarkowsky,¹ D. Stone,¹ M. Eslami,² M. Malas,³ P. Goodney.¹
¹Vascular Surgery, Dartmouth Hitchcock Medical Center, Lebanon, NH; ²Vascular Surgery, Boston Medical Center, Boston, MA; ³School of Public Health, John Hopkins Medical School, Baltimore, MD.
BACKGROUND:Contrast-induced nephropathy following endovascular aortic aneurysm repair (EVAR) in renal transplant patients can have devastating consequences. We describe outcomes within a national cohort of kidney…
2016 American Transplant Congress
Exosome-Like Vesicles Released in Association with Tissue Injury Trigger Anti-LG3 Production.
M. Dieudé,^1,2,3 J. Turgeon,^1,3 B. Yang,^1,2,3 L. Pomerleau,^1,3 K. Hamelin,^1,3 S. Lan,^1,2,3 S. Qi,^1,3 D. Gingras,^1,3 W. Dhari,¹ A. Rivard,¹ M.-J. Hébert.^1,2,3
¹Research Centre, Centre hospitalier de l'Université de Montréal, Montréal, Canada; ²Université de Montréal, Montréal, Canada; ³Canadian National Transplantation Research Program, Edmonton, Canada.
Pre-transplant levels of autoantibodies to perlecan/LG3 predict poor allograft outcomes in renal transplant patients. We showed previously thatapoptotic exosome-like vesicles (ApoExo) enhance anti-LG3 production and…
2016 American Transplant Congress
Air Pollution – An Additional Risk Factor for Developing Cardiac Allograft Vasculopathy.
C. Bara, D. Böthig, Y. Scheibner, D. Bobylev, B. Przybylek, A. Haverich.
Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Purpose:Cardiac allograft vasculopathy (CAV) remains one of the primary causes of death in long-term follow-up after heart transplantation (HTx) and is the most limiting factor…