2020 American Transplant Congress
Evaluation of Pretransplant Serologies and Vaccination Rates in Kidney Transplant Candidates
Department of Pharmacy Services, University of Utah Health, Salt Lake City, UT
*Purpose: Assessing serologic status presents opportunities to provide live vaccinations to solid organ transplant (SOT) candidates. This is especially important given the increased risk of…2020 American Transplant Congress
HLA-Antibody Develops Preferentially in Healthy Subjects with a T-bethiB Cell Response to Vaccine
University of Alabama, Birmingham, AL
*Purpose: Bystander B cell differentiation into antibody (Ab) secreting cells (ASCs) may augment alloimmunity in the HLA-sensitized patient. Recently, a population of FcrL5+IgDnegB cells that…2020 American Transplant Congress
DEPTOR Expression within CD4+Foxp3+ T Regulatory Cells is Crucial for B Cell Activation Responses and Immunoregulation
1Boston Children's Hospital, Boston, MA, 2Lavel University, Quebec, QC, Canada
*Purpose: We have previously reported that the intracellular protein DEPTOR stabilizes Foxp3 expression, enhances suppressive Treg function and inhibits Treg dedifferentiation. Overexpression of DEPTOR within…2020 American Transplant Congress
Direct Acting Anti-Viral Prophylaxis to Prevent Virus Transmission from Hepatitis C Viremic Donors to Hepatitis C Negative Kideney Transplant Recipients
Virginia Commonwealth University, Richmond, VA
*Purpose: Previous trials in kidney transplantation (KT) have described a 12-week course of direct-acting anti-viral drugs (DAA) to treat HCV transmission from infected donors to…2020 American Transplant Congress
Use of Subunit Herpes Zoster Vaccine in VZV-Seronegative Transplant Recipients to Prevent Primary Varicella
*Purpose: Varicella-zoster virus (VZV) primary infection can be prevented by using the live varicella vaccine. However, this is contraindicated after organ transplant. We investigated the…2020 American Transplant Congress
Safety and Immunogenicity of Adjuvanted Recombinant Subunit Herpes Zoster Vaccine in Lung Transplant Recipients
1University Health Network, Toronto, ON, Canada, 2CDC, Atlanta, GA
*Purpose: The new adjuvanted subunit recombinant herpes zoster vaccine (RZV; Shingrix™) may have potential utility in transplant patients for the prevention of shingles, but there…2020 American Transplant Congress
Role of Peptide Antigen, Antigen-Presenting Cells and CD4 T Cells in Modulating BK Polyomavirus (BKPyV)-Specific CD8 T Cell Responses In Vitro
Biomedicine, University of Basel, Basel, Switzerland
*Purpose: BKPyV persists as significant cause of premature kidney transplant failure. Current treatment is based on reducing immunosuppression to regain immune control over BKPyV replication…2019 American Transplant Congress
Vaccination Rates and Relation to Health Beliefs in Inner-City Kidney Transplant Recipients (KTRs)
SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: Prophylaxis against viral and bacterial infections as outlined by guidelines issued by the 2013 Infectious Diseases Society of America (IDSA) Clinical Practice Guideline for…2019 American Transplant Congress
A CMV Vaccine Based on Non-Replicating Lymphocytic Choriomeningitis Virus Vectors Expressing gB and pp65 is Safe and Immunogenic in Healthy Volunteers and Entering a Phase 2 Trial in Kidney Transplant Recipients
*Purpose: Cytomegalovirus (CMV) is a significant pathogen in pregnancy and immunocompromised patients. Antiviral prophylaxis is limited by toxicities, recurrent infection, and resistance. A safe and…2019 American Transplant Congress
Vaccine Response as a Predictor of Kidney Transplant Rejection and Serious Infection
Department of Nephrology, Monash Health, Clayton, Australia
*Purpose: Vaccination generates immune memory, including antibodies against harmful pathogens. Transplant immunosuppression prevents similar processes occurring against alloantigens. Transplant recipients have significantly reduced seroresponses to…
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