Articles tagged "Vaccination"

2021 American Transplant Congress
Limited Immunogenicity of a Single Dose of Sars-cov-2 Mrna Vaccine in Solid Organ Transplant Recipients
B. Boyarsky, M. Ou, R. Greenberg, A. Teles, W. Werbel, R. Avery, A. Tobian, A. Massie, D. Segev, J. Garonzik Wang
Johns Hopkins, Baltimore, MD
*Purpose: Given substantial challenges with vaccine allocation and evidence for short-term vaccine efficacy after a single dose of SARS-CoV-2 mRNA vaccines in clinical trials, some…
2021 American Transplant Congress
Detection of SARS-CoV-2 Specific Functional T Cells Using a Seven Color Flow Cytometry Assay
L. Flebbe-Rehwaldt, J. Hayden, K. Mickey, S. Manley, S. Kleiboeker
Eurofins-Viracor, Lees Summit, MO
*Purpose: The need to evaluate SARS-CoV-2 immune responses is an important clinical research focus. Detecting neutralizing antibodies is one measure of immune response, but the…
2020 American Transplant Congress
Improving Vaccination Rates for Influenza and Pneumococcal Disease in Pediatric Kidney Transplant Recipients
A. M. McGrath¹, J. Baquir¹, L. Maestretti¹, G. James¹, K. DiNello¹, M. Patton¹, A. Fong¹, A. Gallo², V. Sigurjonsdottir², P. Grimm², A. Chaudhuri²
¹Pediatric Kidney Transplant, Lucile Packard Children's Hospital Stanford, Palo Alto, CA, ²Pediatric Kidney Transplant, Stanford University, Palo Alto, CA
*Purpose: Pediatric renal transplant recipients are highly vulnerable to infections caused by influenza and pneumococcus and vaccines are recommended in this population. At our center,…
2020 American Transplant Congress
Incidence and Effects of Posttransplant Herpes Zoster in Adult Solid Organ Transplant Recipients : A Meta-Analysis
S. H. Han, D. Kwon
Yonsei University Health System, Seoul, Korea, Republic of
*Purpose: Recently, non-live recombinant subunit HZ vaccine showed highly effective for herpes zoster (HZ) in hematopoietic stem cell transplantation. Several observational studies reported various features…
2020 American Transplant Congress
Vaccine Safety Concerns and Relationship to Comfort with Provider Communication in a Population of Inner-City Kidney Transplant Recipients
T. Morancy, I. Nadeem, G. Cordero, D. Lee, M. Markell
SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: Misperceptions and incorrect beliefs among patients may contribute to patient refusal of vaccines. We examined beliefs and sources of information in a population of…
2020 American Transplant Congress
Risk Factors for Losing Varicella Immunity after Pediatric Kidney Transplantation
H. Pizzo¹, J. Mirocha², J. Garrison¹, P. R. Soni³, S. Nadipuram³, D. Puliyanda¹
¹Pediatric Nephrology, Cedars-Sinai Medical Center, Los Angeles, CA, ²Biostatistics Core, Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, ³Pediatric Infectious Disease, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Vaccination against varicella zoster (VZV) pre-kidney transplant (kid tx) can help prevent severe disseminated VZV disease in immunosuppressed patients (pts) post-tx. Despite confirmation of…
2020 American Transplant Congress
Evaluation of Pretransplant Serologies and Vaccination Rates in Kidney Transplant Candidates
S. Schneider, C. Truax, A. Carlson, B. Clark, B. Sirandas, L. Smith
Department of Pharmacy Services, University of Utah Health, Salt Lake City, UT
*Purpose: Assessing serologic status presents opportunities to provide live vaccinations to solid organ transplant (SOT) candidates. This is especially important given the increased risk of…
2020 American Transplant Congress
HLA-Antibody Develops Preferentially in Healthy Subjects with a T-bet^hiB Cell Response to Vaccine
A. Nellore, G. R. Martens, J. T. Killian, J. Houp, E. Zumaquero, B. Mousseau, J. Bradley, F. Zhou, P. A. Goepfert, F. E. Lund
University of Alabama, Birmingham, AL
*Purpose: Bystander B cell differentiation into antibody (Ab) secreting cells (ASCs) may augment alloimmunity in the HLA-sensitized patient. Recently, a population of FcrL5+IgDnegB cells that…
2020 American Transplant Congress
DEPTOR Expression within CD4⁺Foxp3⁺ T Regulatory Cells is Crucial for B Cell Activation Responses and Immunoregulation
J. Wedel¹, M. Maslyar¹, S. Kong¹, M. Laplante², D. M. Briscoe¹
¹Boston Children's Hospital, Boston, MA, ²Lavel University, Quebec, QC, Canada
*Purpose: We have previously reported that the intracellular protein DEPTOR stabilizes Foxp3 expression, enhances suppressive Treg function and inhibits Treg dedifferentiation. Overexpression of DEPTOR within…
2020 American Transplant Congress
Direct Acting Anti-Viral Prophylaxis to Prevent Virus Transmission from Hepatitis C Viremic Donors to Hepatitis C Negative Kideney Transplant Recipients
G. Gupta, I. Yakubu, D. Kumar, I. Moinuddin, L. Kamal, A. King, C. Bhati, A. Sharma, A. Cotterell, A. Khan, M. Levy, R. Sterling
Virginia Commonwealth University, Richmond, VA
*Purpose: Previous trials in kidney transplantation (KT) have described a 12-week course of direct-acting anti-viral drugs (DAA) to treat HCV transmission from infected donors to…