2018 American Transplant Congress
Mitochondrial Quality Control through PGC-1α in Syngenic Mouse Heart Transplant
1Anesthesiology, Duke University, Durham, NC; 2Surgery, Duke University, Durham, NC.
Intro: Impaired mitochondrial function plays a role in graft dysfunction after transplant, and recovery is facilitated by mitochondrial quality control (MQC). Two key elements of…2017 American Transplant Congress
High CTLA-4 Expression and Diminished FOXO3 Expression Underlie Differential CD28 Signaling on Human Memory Th17 Cells.
Pathogen primed memory T cells can cross-react with allogeneic antigen and mediate graft rejection, a process termed allogeneic heterologous immunity. Th17 cells are pro-inflammatory CD4+…2017 American Transplant Congress
Vital Role of the CoREST Complex as a Master Regulator of Foxp3+ T-Regulatory Cell Gene Expression and Suppressive Function.
While the Foxp3 promoter and its three associated conserved non-coding sequence (CNS)/enhancer regions have received much attention, literally nothing is known of the contribution of…2017 American Transplant Congress
Transcriptome Analysis of CD4-Lymphocyte Specifically Deleted of IKKbeta or NEMO in an Experimental Model of Rapid Progressive Glomerulonephritis (RPGN).
RPGN is T-cell mediated and can recur after kidney transplantation. T-cell receptor stimulation leads to intracellular signaling events ultimately causing activation of transcription factors such…2016 American Transplant Congress
Hydrogen Sulphide Is an Important Regulator of Erythropoietin Synthesis in Patients with Anemia of Chronic Kidney Disease.
Anemia affects 90% of hemodialysis patients and is a tremendous concern for patients and health care providers. CKD leads to chronic interstitial fibrosis which leads…2016 American Transplant Congress
IL-17-Producing CCR6+CD4+ Th17 Cells Drive Intestinal Allograft Rejection in Humans.
MedStar Georgetown Transplant Institute, Washington DC.
A. Allograft rejection remains a significant source of mortality and morbidity in intestinal transplant (ITx) recipients. However, the underlying mechanisms remain unclear. The purpose of…2016 American Transplant Congress
T-Bet Regulates nTreg Stability and Suppression in an Islet Allograft Model.
University of Maryland, Baltimore.
The transcription factor T-bet endows Treg with properties tosuppress Th1 inflammation. However, the mechanisms by which T-bet controls alloimmune responses are not fully understood. We…2016 American Transplant Congress
Liver Graft Rejuvenation Prior to Transplantation: A Bench-to-Bedside Approach.
1Surgery, Dumont-UCLA Translant Center, Los Angeles, CA; 2Pathology, UCLA, Los Angeles, CA.
To address the shortage of organs for transplantation many use “marginal” livers, which are particularly susceptible to ischemia-reperfusion injury (IRI). We have taken a two-pronged…2015 American Transplant Congress
Th-17 Alloimune Responses in Renal Allograft Biopsies from Recipients of Kidney Transplants Using Extended Criteria Donors During Acute T-Cell Mediated Rejection
Although renal transplantation using expanded criteria donors has become a common practice, immune responses related to immunosenescence in those kidney allografts have not been studied…2015 American Transplant Congress
Pro-Inflammatory Actions of New Non-HLA Antibodies Targeting Protease-Activated Receptor (PAR-1)
Microvascular endothelium is major target for antibodies directed against HLA and non-HLA antigens. Functional antibodies targeting G-protein coupled receptors (GPCRs) such as AT1R or ETAR…
American Transplant Congress abstracts