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American Transplant Congress abstracts

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Articles tagged "Tolerance"

  • 2021 American Transplant Congress

    Prediction of Renal Allograft Tolerance by Machine Learning

    Q. Fu1, K. Deng2, H. Yang1, S. Deng1, J. F. Markmann2

    1Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Sciences and Technology of China, Chengdu, China, 2Center for Transplantation Sciences, MGH, Boston, MA

    *Purpose: An ideal goal of transplantation is to withdraw or minimize immunosuppressants via the induction of tolerance to overcome drug toxicity, prolong allograft survival, and…
  • 2021 American Transplant Congress

    Expansion of Cd45ra-foxp3hi Activated Regulatory T Cells Predict Immune Tolerance in Patients with Combined Kidney and Bone Marrow Transplantation

    Y. Kwon1, K. Lee2, J. Park2

    1Transplantation Research Center, Samsung Medical Center, Seoul, Korea, Republic of, 2Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of

    *Purpose: Simultaneous transplantation of a solid organ and bone marrow from an identical donor is a possible means of achieving transplant tolerance. Here, we attempted…
  • 2021 American Transplant Congress

    Primary Outcome of OPTIMAL: A Prospective Multicenter Trial of Immunosuppression Withdrawal (ISW) in Stable Adult Liver Transplant (LT) Recipients

    S. Chandran1, K. Mason2, L. F. Sun1, N. Tanimine3, M. DesMarais1, B. Burrell1, J. F. Markmann3

    1ITN, San Francisco, CA, 2Rho, Inc., Durham, NC, 3MGH, Boston, MA

    *Purpose: To identify clinical & mechanistic correlates of successful ISW and operational tolerance (OT) in a selected cohort of adult LT recipients.*Methods: The Immune Tolerance…
  • 2021 American Transplant Congress

    Inducing Transient Mixed Chimerism without Chimeric Transition Syndrome for Tolerance Induction After Kidney Transplantation

    K. Lee, J. Park

    Samsung Medical Center, Seoul, Korea, Republic of

    *Purpose: Immunological or operational tolerance, defined as the absence of a destructive immune response to a transplanted tissue without ongoing immunosuppression, is one strategy that…
  • 2021 American Transplant Congress

    Characterisation of Distinct Graft Infiltrates Following Cellular Therapy in Kidney Transplant Recipients

    M. O. Brook1, P. N. Harden2, I. Roberts2, W. R. Mulley3, J. Hester1, M. E. Reinders4, F. Issa1

    1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 2Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom, 3Department of Nephrology, Monash Medical Centre, Melbourne, Australia, 4Division of Nephrology and Transplant Center, Leiden University Medical Center, Leiden, Netherlands

    *Purpose: Cellular therapy is an emerging treatment in the field of clinical transplantation with the potential to improve both short and long-term transplant outcomes. We…
  • 2021 American Transplant Congress

    In Vitro Generated Regulatory B Cells Induce Cd4+Cd25+Foxp3+Tregs from Cd4+Cd25–T Cells via TGF-β

    G. Huai1, K. Lee2, K. Deng2, Q. Fu1, C. G. Rickert2, S. Deng1, C. LeGuern2, J. F. Markmann2

    1Department of Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China, 2Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA

    *Purpose: Our team previous study showed that TLR-Bregs, stimulated through TLR pathway in vitro, harbored regulatory properties by suppressing CD4+ T cell proliferation and function…
  • 2021 American Transplant Congress

    Long-Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients

    J. Leventhal1, J. Galvin2, J. Mathew1, L. Gallon1, D. Belshe1, M. Gibson1, K. Ravindra3, M. Horwitz3, S. Ildstad4

    1Northwestern University, Comprehensive Transplant Center, Chicago, IL, 2Northwestern University, Chicago, IL, 3Duke Medical Center, Durham, NC, 4University of Louisville, Llouisville, KY

    *Purpose: 37 subjects were transplanted in a phase 2 protocol based upon tolerogenic CD8+/TCR-facilitating cells (FCR001) to induce tolerance in recipients of living donor renal…
  • 2021 American Transplant Congress

    Peripheral Blood Hematopoietic Chimerism: A Robust Biomarker for Transplantation Tolerance

    D. Tollerud1, E. Gornstein1, J. Leventhal2, K. V. Ravindra3, S. Ildstad1

    1Talaris Therapeutics, Louisville, KY, 2Division of Organ Transplantation, Northwestern Medical Group, Chicago, IL, 3Department of Surgery, Duke University Medical Center, Durham, NC

    *Purpose: Despite the development of highly effective immunosuppressive medications, organ rejection and the toxicity of the drugs themselves remain significant obstacles to long-term graft and…
  • 2021 American Transplant Congress

    Transgenic Beta-cell Cxcl12 Expression and Stem Cell Mobilization Synergize to Suppress Type 1 Diabetes

    D. A. Alagpulinsa, A. Jajoo, M. H. Chapin II, M. C. Poznansky

    Vaccine & Immunotherapy Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA

    *Purpose: Hematopoietic stem and progenitor cells (HSPCs) and regulatory T cells (Tregs) highly express CXCR4, the receptor for the CXCL12 chemokine. This keeps them predominantly…
  • 2021 American Transplant Congress

    Immunologic Benefits of Maternal Living Donor Allografts in Pediatric Liver Transplantation: Less Rejection Episodes and No Evidence of De Novo Allosensitization

    A. Barbetta1, G. Meeberg2, B. Rocque1, S. Barhouma3, S. Gilmour4, F. Faytrouni5, O. Guttman5, P. Campbell4, J. Shapiro2, J. Emamaullee1

    1Surgery, Abdominal Transplant, University of Southern California, Los Angeles, CA, 2Surgery, University of Alberta, Edmonton, AB, Canada, 3University of Southern California, Los Angeles, CA, 4University of Alberta, Edmonton, AB, Canada, 5University of British Columbia, Vancouver, BC, Canada

    *Purpose: Living donor liver transplantation (LDLT) offers improved graft and patient survival in pediatric liver transplant (LT) recipients. Prior studies have suggested immunological advantage when…
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