Articles tagged "Tolerance"

2021 American Transplant Congress
Transgenic Beta-cell Cxcl12 Expression and Stem Cell Mobilization Synergize to Suppress Type 1 Diabetes
D. A. Alagpulinsa, A. Jajoo, M. H. Chapin II, M. C. Poznansky
Vaccine & Immunotherapy Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA
*Purpose: Hematopoietic stem and progenitor cells (HSPCs) and regulatory T cells (Tregs) highly express CXCR4, the receptor for the CXCL12 chemokine. This keeps them predominantly…
2021 American Transplant Congress
Immunologic Benefits of Maternal Living Donor Allografts in Pediatric Liver Transplantation: Less Rejection Episodes and No Evidence of De Novo Allosensitization
A. Barbetta¹, G. Meeberg², B. Rocque¹, S. Barhouma³, S. Gilmour⁴, F. Faytrouni⁵, O. Guttman⁵, P. Campbell⁴, J. Shapiro², J. Emamaullee¹
¹Surgery, Abdominal Transplant, University of Southern California, Los Angeles, CA, ²Surgery, University of Alberta, Edmonton, AB, Canada, ³University of Southern California, Los Angeles, CA, ⁴University of Alberta, Edmonton, AB, Canada, ⁵University of British Columbia, Vancouver, BC, Canada
*Purpose: Living donor liver transplantation (LDLT) offers improved graft and patient survival in pediatric liver transplant (LT) recipients. Prior studies have suggested immunological advantage when…
2021 American Transplant Congress
Quilty Lesions are Associated with a Tolerance Profile in Heart Allografts Biopsies
J. Torrealba, S. Moore, S. Sathirareuangchai, L. De Las Casas, Q. Cai
Pathology, UTSW Medical Ctr, Dallas, TX
*Purpose: Previously, in 42 cardiac allograft biopsies, we demonstrated that the presence of Foxp3+ innate and TGF- β + adaptive regulatory lymphocytes in Quilty lesions…
2021 American Transplant Congress
Enhancement of Regulatory T Cell Therapies by Biomimetic Nanofiber Matrices on Single Cells
L. A. Fraser¹, S. Lee¹, Y. Sambandam², J. He², X. Huang², D. Z. Ivancic², J. Mathew², Z. J. Zhang², J. R. Leventhal², L. Gallon², S. I. Stupp¹
¹Simpson Querrey Institute, Northwestern, Chicago, IL, ²Surgery – Comprehensive Transplant Center, Northwestern, Chicago, IL
*Purpose: Here we report a new method to create an artificial and biodegradable matrix of biomimetic nanofibers on single cells with the goal of enhancing…
2021 American Transplant Congress
MDR-101-MLK-MERCURY Kidney Transplant Tolerance Study Update
D. Kaufman¹, S. Akkina², M. Stegall³, J. Piper⁴, A. O. Gaber⁵, E. Marin⁶, S. Busque⁷, D. Alonso⁸, M. De Vera⁹, A. Shah¹⁰, A. Patel¹¹, K. Chavin¹², M. Laftavi¹³, S. Collette¹⁴, E. Stites¹⁵, M. Mai¹⁶, M. Cooper¹⁷, D. Brennan¹⁸
¹Surgery, UW, Madison, WI, ²Surgery, Loyola, Chicago, IL, ³Surgery, Mayo, Rochester, MN, ⁴Surgery, Inova, Fairfax, VA, ⁵Surgery, Houston Methodist, Houston, TX, ⁶Nephrology, Yale, New Haven, CT, ⁷Surgery, Stanford, San Francisco, CA, ⁸Surgery, Intermountain, Murray, UT, ⁹Surgery, Loma Linda, Loma Linda, CA, ¹⁰Surgery, TJU, Philadelphia, PA, ¹¹Nephrology, St. Barnabas, Livingston, NJ, ¹²Surgery, UHH, Cincinnati, OH, ¹³Surgery, Upstate, Syracuse, NY, ¹⁴Surgery, CIUSSS, Montreal, ON, Canada, ¹⁵Nephrology, UC Denver, Denver, CO, ¹⁶Nephrology, Mayo - FL, Jacksonville, FL, ¹⁷Surgery, Georgetown, Washington, DC, ¹⁸Medeor, San Francisco, CA
*Purpose: We report interim results of the Phase 3 MERCURY tolerance study, which produces mixed chimerism and ultimately generates operational tolerance allowing for the elimination…
2021 American Transplant Congress
Effects of IL-18 on Key Post-Translational Modifications of Human Foxp3 and Innate Immunity
T. Akimova¹, L. M. Christensen¹, Z. Wang², M. H. Levine², W. W. Hancock¹
¹CHOP & University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA
*Purpose: Most of our ideas about Treg cells are extrapolated from findings in mice, with actual clinical data typically involving flow cytometric enumeration of CD4+FOXP3+…
2021 American Transplant Congress
Reassessing TCMR in Kidney Transplant Indication Biopsies: Emerging Evidence for Partial Exhaustion in Late TCMR
P. Halloran¹, J. Reeve¹, &. the INTERCOMEX Study Group²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: We rederived the MMDx rejection archetypes in an expanded set of 1679 kidney transplant biopsies to add power and potentially define heterogeneity in TCMR.…
2021 American Transplant Congress
IL-10 Signaling in T Cells Modulates Costimulation-independent Activation and is Essential for Transplant Tolerance Induction
M. Iglesias Lozano¹, D. Bibicheff¹, M. Chicco², A. Komin¹, G. Brandacher¹, G. Raimondi¹
¹Plastic Surgery, Johns Hopkins University, Baltimore, MD, ²Frimley Health NHS Foundation Trust, London, United Kingdom
*Purpose: Costimulation blockade (CoB)-based immunotherapy remains a very promising approach for better management of transplant recipients. Understanding the mechanisms that impact the efficacy of CoB…
2021 American Transplant Congress
TIGIT Identifies Polyfunctional Donor-Specific CD4+ T Cells Lost After Kidney Transplantation
A. C. van der List, N. H. Litjens, M. G. Betjes, M. Klepper
Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands
*Purpose: Development of T-cell hyporesponsiveness to donor antigen may explain the substantial decrease in the risk for acute rejection in the years following kidney transplantation.…
2021 American Transplant Congress
Proteomic Analysis of Extracellular Vesicles Derived From a Potent Donor-specific Regulatory T Cell-enriched Population Demonstrates Multiple Markers of Immune Suppression
B. Schreiber¹, S. Tripathi¹, M. Blaser², T. Pham², S. Kuraoka², S. A. Singh², E. Aikawa², A. Chandraker¹
¹Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA, ²Center for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA
*Purpose: Extracellular vesicles (EVs) are emerging as vital mediators of intercellular communication and immune regulation. Regulatory T cells (Tregs) play an integral role in immune…

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