2021 American Transplant Congress
The Gut Microbiotainduces Local and Systemic Immune Modulation
*Purpose: We previously demonstrated that gut microbiome alterations, through fecal microbiota transfer (FMT) or single bacteria transfer, had specific immune effects for cardiac allograft outcome.…2021 American Transplant Congress
Results of Litmus (nct 02541916): The Liver Immune Tolerance Bio Marker Utilization Study
*Purpose: Although it is known that some liver transplant recipients are operationally tolerant and can be weaned off immunosuppression (IS), there is not currently a…2021 American Transplant Congress
Prediction of Renal Allograft Tolerance by Machine Learning
*Purpose: An ideal goal of transplantation is to withdraw or minimize immunosuppressants via the induction of tolerance to overcome drug toxicity, prolong allograft survival, and…2021 American Transplant Congress
Expansion of Cd45ra-foxp3hi Activated Regulatory T Cells Predict Immune Tolerance in Patients with Combined Kidney and Bone Marrow Transplantation
*Purpose: Simultaneous transplantation of a solid organ and bone marrow from an identical donor is a possible means of achieving transplant tolerance. Here, we attempted…2021 American Transplant Congress
Primary Outcome of OPTIMAL: A Prospective Multicenter Trial of Immunosuppression Withdrawal (ISW) in Stable Adult Liver Transplant (LT) Recipients
1ITN, San Francisco, CA, 2Rho, Inc., Durham, NC, 3MGH, Boston, MA
*Purpose: To identify clinical & mechanistic correlates of successful ISW and operational tolerance (OT) in a selected cohort of adult LT recipients.*Methods: The Immune Tolerance…2021 American Transplant Congress
Inducing Transient Mixed Chimerism without Chimeric Transition Syndrome for Tolerance Induction After Kidney Transplantation
Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Immunological or operational tolerance, defined as the absence of a destructive immune response to a transplanted tissue without ongoing immunosuppression, is one strategy that…2021 American Transplant Congress
Characterisation of Distinct Graft Infiltrates Following Cellular Therapy in Kidney Transplant Recipients
*Purpose: Cellular therapy is an emerging treatment in the field of clinical transplantation with the potential to improve both short and long-term transplant outcomes. We…2021 American Transplant Congress
In Vitro Generated Regulatory B Cells Induce Cd4+Cd25+Foxp3+Tregs from Cd4+Cd25–T Cells via TGF-β
*Purpose: Our team previous study showed that TLR-Bregs, stimulated through TLR pathway in vitro, harbored regulatory properties by suppressing CD4+ T cell proliferation and function…2021 American Transplant Congress
Long-Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients
*Purpose: 37 subjects were transplanted in a phase 2 protocol based upon tolerogenic CD8+/TCR-facilitating cells (FCR001) to induce tolerance in recipients of living donor renal…2021 American Transplant Congress
Peripheral Blood Hematopoietic Chimerism: A Robust Biomarker for Transplantation Tolerance
*Purpose: Despite the development of highly effective immunosuppressive medications, organ rejection and the toxicity of the drugs themselves remain significant obstacles to long-term graft and…
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