Articles tagged "Tolerance"

2021 American Transplant Congress
Clinical Value of Surveillance Biopsies in Pediatric Liver Transplantation: A Single Center Experience with >800 Biopsies
B. Rocque¹, A. Zaldana¹, C. Weaver², J. Huang¹, A. Barbetta¹, V. Shakhin², C. Goldbeck¹, G. Yanni², R. Kohli², Y. Genyk¹, J. Emamaullee¹
¹Surgery, University of Southern California Keck School of Medicine, Los Angeles, CA, ²Pediatrics, Children’s Hospital-Los Angeles, Los Angeles, CA
*Purpose: While pediatric liver transplantation (LT) results in excellent long-term outcomes, a high incidence of early acute cellular rejection (ACR) and late graft fibrosis persists.…
2021 American Transplant Congress
Selective Bcl-2 Inhibition for Induction of Mixed Chimerism and Renal Allograft Tolerance without Myelosupression
G. Lassiter¹, T. Hirose¹, H. Sasaki¹, D. Ma¹, T. Oura¹, A. Dehnadi¹, A. Cosimi¹, P. Cippa², T. Fehr³, T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Division of Nephrology, Ente Ospedaliero Cantonale, Lugano, Switzerland, ³Division of Nephrology, University of Zurich, Zurich, Switzerland
*Purpose: Immunologic tolerance of renal allograft has been achieved by induction of hematopoietic chimerism through donor bone marrow transplantation (DBMT). The myeloablative and genetic toxicity…
2021 American Transplant Congress
Laminin Alpha 4 and Alpha5 Differentially Regulate Lymph Node Tolerogenic Structure
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena¹, T. Zhang¹, J. Iyyathurai², R. Lakhan¹, R. Abdi³, J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²CVID, UMB, Baltimore, MD, ³Harvard University, Boston, MD
*Purpose: Lymph node (LN) stromal laminins α4 (Lama4) and α5 (Lama5) are associated with tolerance and immunity, respectively. We hypothesized that stromal Lama4 and Lama5…
2021 American Transplant Congress
Effects of IL-2 and/ or Anti-IL6R Therapy on Long-term Cardiac Allograft Survival in Non-Human Primates (NHPs)
C. L. Miller, K. J. Ahrens, J. M. O, P. M. Patel, J. A. Morrissette, D. Becerra, T. Costa, A. Dehnadi, I. M. Hanekamp, G. Benichou, J. C. Madsen
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Cardiac allograft tolerance in NHPs has been achieved by our group using a mixed chimerism model with allogeneic bone marrow transplant after non-myeloablative conditioning…
2021 American Transplant Congress
Short-term Therapy with Anti-icam-1 Monoclonal Antibody Induced Long-term Liver Allograft Survival in Non-human Primates
S. Hong¹, D. Han², S. Lee², J. Kim³, E. Hwang³, H. Kim⁴, J. Lee⁵, K. Hong¹, E. Han¹, J. Cho¹, J. Lee¹, Y. Choi¹, K. Lee¹, N. Yi¹, J. Yang¹, K. Suh¹
¹Surgery, Seoul National University College of Medicine, Seoul, Korea, Republic of, ²Biomedical Research Institute, Seoul National University College of Medicine, Seoul, Korea, Republic of, ³Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea, Republic of, ⁴Pathology, Seoul National University College of Medicine, Seoul, Korea, Republic of, ⁵Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of
*Purpose: Tolerance induction remains challenging following liver transplantation and the long-term use of immunosuppressants, especially calcineurin inhibitors, leads to serious complications. We aimed to test…
2021 American Transplant Congress
Regulatory Macrophage Induced by Il-33 Promoted Immune Tolerance of Kidney Transplantation Through Siglec-10
J. d. zhang, w. wang
Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
*Purpose: Acute and chronic rejection are key problems in renal transplantation. It is ideal to induce immune tolerance to suppress rejection while regulatory macrophages (Mregs)…
2021 American Transplant Congress
Novel Discovery of Super-antigen That Mobilize Regulatory Cd8 T Cells Inhibits Donor-specific Antibody and Protects Heart Allografts from Antibody-mediated Rejection
J. Y. Choi¹, H. Nakagawa², Z. Solhjou¹, K. Yatim¹, H. Zhang³, P. Patel³, M. Tawfeek Mohammed³, L. Riella⁴, H. Kim², H. Cantor², J. Azzi¹
¹Brigham and Women's Hospital/Harvard Medical School, Boston, MA, ²Dana Farber Cancer Institute/Harvard Medical School, Boston, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Massachusetts General Hospital/Harvard Medical School, Boston, MA
*Purpose: Antibody-mediated rejection (AMR) is a critical barrier to long-term allograft survival. We showed that Qa-1 (HLA-E in humans) restricted CD8+ T cells (CD8 Treg)…
2021 American Transplant Congress
Analysis of Single Cell RNA Sequencing Data to Define Biomarkers of Human Liver Immune Tolerance
B. Rocque¹, A. Barbetta¹, P. Singh¹, C. Goldbeck¹, D. G. Helou², E. Loh³, N. Ung⁴, J. S. Lee⁴, O. Akbari², J. Emamaullee¹
¹Surgery, University of Southern California Keck School of Medicine, Los Angeles, CA, ²Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, ³Norris Medical Library, University of Southern California Keck School of Medicine, Los Angeles, CA, ⁴Ellison Institute, University of Southern California, Los Angeles, CA
*Purpose: The liver is unique in its ability to maintain immune homeostasis and promote operational tolerance following solid organ transplantation. Single-cell RNA sequencing (scRNA seq)…
2021 American Transplant Congress
The Gut Microbiotainduces Local and Systemic Immune Modulation
V. Saxena, R. Lakhan, J. Iyyathurai, W. Piao, L. Li, T. Zhang, M. W. Shirkey, B. Ma, E. F. Mongodin, J. Bromberg
U Maryland, Baltimore, MD
*Purpose: We previously demonstrated that gut microbiome alterations, through fecal microbiota transfer (FMT) or single bacteria transfer, had specific immune effects for cardiac allograft outcome.…
2021 American Transplant Congress
Results of Litmus (nct 02541916): The Liver Immune Tolerance Bio Marker Utilization Study
A. Chruscinski¹, V. Rojas-Luengas¹, A. Issacher¹, L. Lilly¹, E. Renner¹, M. Epstein¹, O. Adeyi¹, S. Fischer¹, Z. Galvin¹, S. Moshkelgosha¹, E. Jaeckel², S. Juvet¹, N. Selzner¹, G. Levy¹
¹Multi-Organ Transplantation, University Health Network, Toronto, ON, Canada, ²Hannover Medical School, Hannover, Germany
*Purpose: Although it is known that some liver transplant recipients are operationally tolerant and can be weaned off immunosuppression (IS), there is not currently a…

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