2021 American Transplant Congress
Long-Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients
*Purpose: 37 subjects were transplanted in a phase 2 protocol based upon tolerogenic CD8+/TCR-facilitating cells (FCR001) to induce tolerance in recipients of living donor renal…2021 American Transplant Congress
Peripheral Blood Hematopoietic Chimerism: A Robust Biomarker for Transplantation Tolerance
*Purpose: Despite the development of highly effective immunosuppressive medications, organ rejection and the toxicity of the drugs themselves remain significant obstacles to long-term graft and…2021 American Transplant Congress
Transgenic Beta-cell Cxcl12 Expression and Stem Cell Mobilization Synergize to Suppress Type 1 Diabetes
*Purpose: Hematopoietic stem and progenitor cells (HSPCs) and regulatory T cells (Tregs) highly express CXCR4, the receptor for the CXCL12 chemokine. This keeps them predominantly…2021 American Transplant Congress
Immunologic Benefits of Maternal Living Donor Allografts in Pediatric Liver Transplantation: Less Rejection Episodes and No Evidence of De Novo Allosensitization
*Purpose: Living donor liver transplantation (LDLT) offers improved graft and patient survival in pediatric liver transplant (LT) recipients. Prior studies have suggested immunological advantage when…2021 American Transplant Congress
Quilty Lesions are Associated with a Tolerance Profile in Heart Allografts Biopsies
Pathology, UTSW Medical Ctr, Dallas, TX
*Purpose: Previously, in 42 cardiac allograft biopsies, we demonstrated that the presence of Foxp3+ innate and TGF- β + adaptive regulatory lymphocytes in Quilty lesions…2021 American Transplant Congress
Enhancement of Regulatory T Cell Therapies by Biomimetic Nanofiber Matrices on Single Cells
*Purpose: Here we report a new method to create an artificial and biodegradable matrix of biomimetic nanofibers on single cells with the goal of enhancing…2021 American Transplant Congress
MDR-101-MLK-MERCURY Kidney Transplant Tolerance Study Update
*Purpose: We report interim results of the Phase 3 MERCURY tolerance study, which produces mixed chimerism and ultimately generates operational tolerance allowing for the elimination…2021 American Transplant Congress
Effects of IL-18 on Key Post-Translational Modifications of Human Foxp3 and Innate Immunity
1CHOP & University of Pennsylvania, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA
*Purpose: Most of our ideas about Treg cells are extrapolated from findings in mice, with actual clinical data typically involving flow cytometric enumeration of CD4+FOXP3+…2021 American Transplant Congress
Reassessing TCMR in Kidney Transplant Indication Biopsies: Emerging Evidence for Partial Exhaustion in Late TCMR
1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2., ., AB, Canada
*Purpose: We rederived the MMDx rejection archetypes in an expanded set of 1679 kidney transplant biopsies to add power and potentially define heterogeneity in TCMR.…2021 American Transplant Congress
IL-10 Signaling in T Cells Modulates Costimulation-independent Activation and is Essential for Transplant Tolerance Induction
*Purpose: Costimulation blockade (CoB)-based immunotherapy remains a very promising approach for better management of transplant recipients. Understanding the mechanisms that impact the efficacy of CoB…
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