Articles tagged "Tolerance"

2021 American Transplant Congress
Novel Discovery of Super-antigen That Mobilize Regulatory Cd8 T Cells Inhibits Donor-specific Antibody and Protects Heart Allografts from Antibody-mediated Rejection
J. Y. Choi¹, H. Nakagawa², Z. Solhjou¹, K. Yatim¹, H. Zhang³, P. Patel³, M. Tawfeek Mohammed³, L. Riella⁴, H. Kim², H. Cantor², J. Azzi¹
¹Brigham and Women's Hospital/Harvard Medical School, Boston, MA, ²Dana Farber Cancer Institute/Harvard Medical School, Boston, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Massachusetts General Hospital/Harvard Medical School, Boston, MA
*Purpose: Antibody-mediated rejection (AMR) is a critical barrier to long-term allograft survival. We showed that Qa-1 (HLA-E in humans) restricted CD8+ T cells (CD8 Treg)…
2021 American Transplant Congress
Analysis of Single Cell RNA Sequencing Data to Define Biomarkers of Human Liver Immune Tolerance
B. Rocque¹, A. Barbetta¹, P. Singh¹, C. Goldbeck¹, D. G. Helou², E. Loh³, N. Ung⁴, J. S. Lee⁴, O. Akbari², J. Emamaullee¹
¹Surgery, University of Southern California Keck School of Medicine, Los Angeles, CA, ²Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, ³Norris Medical Library, University of Southern California Keck School of Medicine, Los Angeles, CA, ⁴Ellison Institute, University of Southern California, Los Angeles, CA
*Purpose: The liver is unique in its ability to maintain immune homeostasis and promote operational tolerance following solid organ transplantation. Single-cell RNA sequencing (scRNA seq)…
2021 American Transplant Congress
The Gut Microbiotainduces Local and Systemic Immune Modulation
V. Saxena, R. Lakhan, J. Iyyathurai, W. Piao, L. Li, T. Zhang, M. W. Shirkey, B. Ma, E. F. Mongodin, J. Bromberg
U Maryland, Baltimore, MD
*Purpose: We previously demonstrated that gut microbiome alterations, through fecal microbiota transfer (FMT) or single bacteria transfer, had specific immune effects for cardiac allograft outcome.…
2021 American Transplant Congress
Results of Litmus (nct 02541916): The Liver Immune Tolerance Bio Marker Utilization Study
A. Chruscinski¹, V. Rojas-Luengas¹, A. Issacher¹, L. Lilly¹, E. Renner¹, M. Epstein¹, O. Adeyi¹, S. Fischer¹, Z. Galvin¹, S. Moshkelgosha¹, E. Jaeckel², S. Juvet¹, N. Selzner¹, G. Levy¹
¹Multi-Organ Transplantation, University Health Network, Toronto, ON, Canada, ²Hannover Medical School, Hannover, Germany
*Purpose: Although it is known that some liver transplant recipients are operationally tolerant and can be weaned off immunosuppression (IS), there is not currently a…
2021 American Transplant Congress
Prediction of Renal Allograft Tolerance by Machine Learning
Q. Fu¹, K. Deng², H. Yang¹, S. Deng¹, J. F. Markmann²
¹Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Sciences and Technology of China, Chengdu, China, ²Center for Transplantation Sciences, MGH, Boston, MA
*Purpose: An ideal goal of transplantation is to withdraw or minimize immunosuppressants via the induction of tolerance to overcome drug toxicity, prolong allograft survival, and…
2021 American Transplant Congress
Expansion of Cd45ra-foxp3hi Activated Regulatory T Cells Predict Immune Tolerance in Patients with Combined Kidney and Bone Marrow Transplantation
Y. Kwon¹, K. Lee², J. Park²
¹Transplantation Research Center, Samsung Medical Center, Seoul, Korea, Republic of, ²Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Simultaneous transplantation of a solid organ and bone marrow from an identical donor is a possible means of achieving transplant tolerance. Here, we attempted…
2021 American Transplant Congress
Primary Outcome of OPTIMAL: A Prospective Multicenter Trial of Immunosuppression Withdrawal (ISW) in Stable Adult Liver Transplant (LT) Recipients
S. Chandran¹, K. Mason², L. F. Sun¹, N. Tanimine³, M. DesMarais¹, B. Burrell¹, J. F. Markmann³
¹ITN, San Francisco, CA, ²Rho, Inc., Durham, NC, ³MGH, Boston, MA
*Purpose: To identify clinical & mechanistic correlates of successful ISW and operational tolerance (OT) in a selected cohort of adult LT recipients.*Methods: The Immune Tolerance…
2021 American Transplant Congress
Inducing Transient Mixed Chimerism without Chimeric Transition Syndrome for Tolerance Induction After Kidney Transplantation
K. Lee, J. Park
Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Immunological or operational tolerance, defined as the absence of a destructive immune response to a transplanted tissue without ongoing immunosuppression, is one strategy that…
2021 American Transplant Congress
Characterisation of Distinct Graft Infiltrates Following Cellular Therapy in Kidney Transplant Recipients
M. O. Brook¹, P. N. Harden², I. Roberts², W. R. Mulley³, J. Hester¹, M. E. Reinders⁴, F. Issa¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ²Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom, ³Department of Nephrology, Monash Medical Centre, Melbourne, Australia, ⁴Division of Nephrology and Transplant Center, Leiden University Medical Center, Leiden, Netherlands
*Purpose: Cellular therapy is an emerging treatment in the field of clinical transplantation with the potential to improve both short and long-term transplant outcomes. We…
2021 American Transplant Congress
In Vitro Generated Regulatory B Cells Induce Cd4⁺Cd25⁺Foxp3⁺Tregs from Cd4⁺Cd25^–T Cells via TGF-β
G. Huai¹, K. Lee², K. Deng², Q. Fu¹, C. G. Rickert², S. Deng¹, C. LeGuern², J. F. Markmann²
¹Department of Organ Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China, ²Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA
*Purpose: Our team previous study showed that TLR-Bregs, stimulated through TLR pathway in vitro, harbored regulatory properties by suppressing CD4+ T cell proliferation and function…

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