Articles tagged "Tolerance"

2022 American Transplant Congress
Phase I/ii Car-Treg Cell Therapy Clinical Trial To Induce Long-term Tolerance In Liver Transplant Patients
A. Sanchez-Fueyo¹, A. Taylor¹, D. Collin², C. Nathalie², S. Chris², M. Martinez-Llordella², N. Belmonte², I. McGill², D. Hartl²
¹King's College London, London, United Kingdom, ²Quell Therapeutics Ltd, London, United Kingdom
*Purpose: Life-long pharmacological immunosuppression (IS) is considered essential to prevent rejection following liver transplantation (LT), but is associated with significant side effects such as infections,…
2022 American Transplant Congress
Novel Role of CD74 in Regulatory T Cell Homeostasis and Function in Allo-Immune Response
Z. Solhjou¹, H. Zhang¹, N. Younis¹, J. Choi¹, C. Deban¹, A. Saad¹, A. Halawi¹, Z. Jing¹, R. Bucala², J. Azzi¹
¹Brigham and Women's Hospital, Boston, MA, ²Yale University School of Medicine, New Haven, CT
*Purpose: Identifying new molecular targets based on our understanding of the biology of the allo-immune response in the allograft microenvironment is critical to develop more…
2022 American Transplant Congress
Effector T Cells Potentiate Treg Migration to Allografts
H. Baydoun, M. Fathallah, A. Pena, B. Robinson, G. Camirand
Surgery and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: CD4+ regulatory T cells (Treg) maintain transplantation tolerance through the suppression of immunity in both secondary lymphoid organs and allografts. However, the signals promoting…
2022 American Transplant Congress
Successful Use of Anti-IL-6R Therapy to Achieve Cardiac Allograft Tolerance in Non-Human Primates
C. L. Miller, K. J. Ahrens, J. M. O, P. M. Patel, A. Dehnadi, T. Costa, M. Momodu, J. A. Morrissette, D. Muldoon, I. M. Hanekamp, J. S. Allan, G. Benichou, J. C. Madsen
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: In contrast to kidney allografts, attempts to achieve tolerance of isolated cardiac allografts in non-human primates (NHPs) using a mixed chimerism strategy have been…
2022 American Transplant Congress
Using mTOR Inhibitor Nanoimmunotherapy to Induce Cardiac Allograft Tolerance in Non-Human Primates
J. M. O¹, P. M. Patel², A. J. Teunissen³, C. L. Miller⁴, T. Costa¹, M. Momodu¹, D. Muldoon¹, A. Dehnadi¹, I. M. Hanekamp¹, V. Pothula⁵, R. Sanchez-Tarjuelo⁶, G. Prevot⁶, W. J. Mulder⁶, J. Allan⁷, J. Ochando⁸, J. Madsen⁹
¹MGH, Boston, MA, ²Emory University, Atlanta, GA, ³Icahn School of Medicine at Mount Sinai, New york, NY, ⁴Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ⁵Icahn School of Medicine at Mount Sinai, New York, NM, ⁶Icahn School of Medicine at Mount Sinai, New York, NY, ⁷Massachusetts General Hospital - Harvard Medical S, Marblehead, MA, ⁸Mount Sinai School of Med, New York, NY, ⁹Massachusetts General Hospital, Boston, MA
*Purpose: Though tolerance of kidney allografts has been consistently achieved using a mixed-chimerism model, cardiac allografts remain resistant to tolerance induction. Lipoprotein-based nanobiologics loaded with…
2022 American Transplant Congress
Delivery of Extracellular Matrix Targeted Regulatory T Cells by Novel Nanofiber Coatings for Transplantation Therapies
L. Gallon¹, J. K. Carrow², J. He¹, Y. Sambandam¹, X. Lai¹, J. Mathew¹, L. C. Palmer², J. R. Leventhal¹, Z. Zhang¹, S. I. Stupp²
¹Surgery - Transplant, Northwestern University, Chicago, IL, ²Simpson Querrey Institute, Northwestern University, Chicago, IL
*Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models and can mitigate transplant rejection or injury following ischemic reperfusion…
2022 American Transplant Congress
High Dimensional Analysis of IL-10-Producing Human B Cells and Their Characterization in Operationally Tolerant Transplant Recipients
M. C. Glass, D. Glass, J. Oliveria, B. Mbiribindi, C. Esquivel, S. M. Krams, S. C. Bendall, O. M. Martinez
Stanford University Sch of Med, Stanford, CA
*Purpose: Regulatory B cells (Breg) participate in control of alloimmune responses in murine models of graft tolerance and are associated with improved outcomes in clinical…
2022 American Transplant Congress
Why Females Have Weaker Tregs Than Males: Inhibitory Effects of Estrogen Receptor Signaling on Foxp3+ Treg Cell Suppressive Function
L. M. Christensen¹, T. Akimova¹, G. Ge², R. Han¹, L. Wang³, C. O'Brien², M. Levine², W. W. Hancock³
¹Children's Hospital of Philadelphia, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Childrens Hospital of Philadelphia, Philadelphia, PA
*Purpose: Estrogen signaling is thought to play a role in nearly every cell type, but the biological significance of estrogen signaling via estrogen receptors in…
2021 American Transplant Congress
Successful Induction of Hematopoietic Chimerism by Dual Inhibition of Mcl-1 and Bcl-2 Without Myeloablative Treatments in Nonhuman Primates
T. Hirose, D. Ma, G. Lassiter, T. Kawai
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Induction of hematopoietic chimerism by donor bone marrow transplantation (BMT) is essential for achievement of allograft tolerance in clinical HLA mismatched kidney transplantation, while…
2021 American Transplant Congress
Tissue-Specific Features of Immunity Revealed by Single-cell RNA Sequencing of Healthy Human Kidney
S. Q. Crome¹, J. M. Szusz², C. McEvoy¹, J. An¹, S. Clotet-Freixas¹, S. A. MacParland¹, G. D. Bader³, A. Konvalinka¹
¹Toronto General Hospital Research Institute, Ajmera Transplant Centre, University Health Network and the University of Toronto, Toronto, ON, Canada, ²Immunology, University of Toronto, Toronto, ON, Canada, ³Molecular Genetics, University of Toronto, Toronto, ON, Canada
*Purpose: Tissue-resident immune cells reside within distinct niches across organs, where they sustain tissue homeostasis and rapidly respond to perturbations in the local microenvironment. Across…

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