2015 American Transplant Congress
MicroRNA let-7i Targeting IL-10 Via JAK1-STAT3 Signal Pathway Regulates Dendritic Cells Maturation Subsequently Induces Cardiac Allograft Tolerance
Background: Our previous study demonstrated that microRNA (MiR) let-7i could regulate dendritic cells (DCs) maturation and functional state via targeting SOCS1. In this study, we…2015 American Transplant Congress
Neonatal Tolerance: Donor and Host Cells Fuse in Livers of Newborn Mice Injected With F1-Bone Marrow/Spleen Cells
University of Alberta, Edmonton, Canada.
Purpose: Multiple liver cell-types induce immunological tolerance. Indeed liver allografts are often spontaneously accepted in humans and mice. The role of host liver in the…2015 American Transplant Congress
Use of RNA Sequencing for Discovery of Markers of Accommodation in Surveillance Biopsies from Recipients of an ABO-Incompatible Renal Transplant
Recipients of an ABO incompatible transplant have circulating anti-AB antibodies, A and/or B antigens expressed on endothelium and usually C4d deposition on the endothelium, yet…2015 American Transplant Congress
Non-Chimeric HLA-Identical Renal Transplant Tolerance: Regulatory Immunophenotypic/Genomic Biomarkers
Background. We previously described 3-year results of a non-chimeric tolerance protocol in HLA-identical living donor renal transplant (RT) recipients and now report on longer term,…2015 American Transplant Congress
Regulatory T Cells Expanded by Activated iNKT Cells Facilitate Migration of Donor Dendritic Cells Into the Recipient Thymus and Subsequent Establishment of Clonal Deletion
We previously reported that combination therapy using liposomal α-galactosylceramide (lipo-αGC) and anti-CD154 mAb could expand regulatory T cells (Tregs) in vivo through activation of the…2015 American Transplant Congress
Effects of Heart and Lung Co-Transplantation Across a Full MHC Barrier in Miniature Swine
Background: We have previously shown that tolerance of heart allografts across a full MHC barrier can be induced in miniature swine after a 12-day course…2015 American Transplant Congress
The Role of Skin-Specific Immunobiology and Major Histocompatibility Complex Sharing in Vascularized Composite Allograft Tolerance
Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA.
Background: We have developed a reproducible model for induction of tolerance of all components of VCAs across haploidentical MHC barriers in miniature swine. The purpose…2015 American Transplant Congress
Stable and Unstable Chimerism During Immunosuppressive Drug Withdrawal in Tolerant Recipients of HLA Matched Combined Kidney and Hematopoietic Cell Transplants
1Surgery, Stanford University, Palo Alto, CA; 2Medicine, Stanford University, Palo Alto, CA.
Our previous studies showed that 75-80% of HLA matched recipients of combined kidney and hematopoietic cell transplants conditioned with total lymphoid irradiation (TLI) and anti-thymocyte…2015 American Transplant Congress
Myeloid Cells as a Key Mediator for Impairment of Transplant Tolerance by CMV Infection
Cytomegalovirus (CMV) is a ubiquitous virus that presents a significant risk for reactivation or de novo infection in transplant recipients. Clinical transplant tolerance has recently…2015 American Transplant Congress
Human Adipose Derived Mesenchymal Stem Cells Enhance Bone Marrow Engraftment and Induce Immunological Tolerance
1UMASS, Worcester; 2Alpert Medical School of Brown University, Providence.
Organ transplantation currently requires long-term immunosuppression. This is associated with multiple complications including infection, malignancy and other toxicities. Immunologic tolerance is considered the optimal solution…
American Transplant Congress abstracts