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Articles tagged "Tolerance"

  • 2015 American Transplant Congress

    Liver-Specific Transcription Factor ATF5 Participates in Regulation of IFN-γ/B7-H1 Signaling Pathway in Liver Mesenchymal Cells

    G.-Q. Shen, L. Wang, J. Fung, L. Lu, S. Qian.

    Immunology, Lerner Research Institute; 2General Surgery, Digestive Disease Insttute, Cleveland Clinic, Cleveland, OH.

    Liver transplant tolerance was initially discovered in pigs, rats and mice. A recent paper reviewed ∼400 liver transplant patients worldwide who had undergone weaning of…
  • 2015 American Transplant Congress

    Sequential Monitoring and Stability of Ex Vivo-Expanded Autologous and Non-Autologous Regulatory T Cells Following Infusion in Non-Human Primates

    H. Zhang,1 H. Guo,1 L. Lu,1 A. Zahorchak,1 R. Wiswman,2 G. Raimondi,1 D. Cooper,1 M. Ezzelarab,1 A. Thomson.1

    1University of Pittsburgh, pittsburgh, PA; 2University of Wisconsin, Madison.

    Ex vivo-expanded cynomolgus monkey CD4+CD25+CD127- regulatory T cells (Treg) maintained Foxp3 demethylation status at the Treg-Specific Demethylation Region (TSDR), and potently suppressed T cell proliferation…
  • 2015 American Transplant Congress

    Noncanonical Anergic Alloreactive B Cells in Transplantation Tolerance

    J. Chen, M. Daniels, D. Yin, R. Sciammas, A. Chong.

    Depart of Surgery, University of Chicago, Chicago.

    The observation that operationally tolerant patients (TOL) display higher numbers of blood B cells and a B cell gene signature compared to stable kidney allograft…
  • 2015 American Transplant Congress

    Notch-1 Inhibition Promotes Immune Regulation in Solid Organ Transplantation

    C. Magee,1 M. Ohari,1 T. Shimizu,1 S. Ohori,1 N. Najafian,2 L. Riella.1

    1Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston; 2Cleveland Clinic, Weston.

    Notch receptor signaling plays a key role in T cell activation and differentiation, though limited data exist on its importance in immune regulation. Herein, we…
  • 2015 American Transplant Congress

    Relative In Vitro Immunoregulatory Effects of Everolimus, Sirolimus, Tacrolimus, Mycophenolic Acid and Drug Combinations

    J. Mathew, X. Huang, J. Leventhal, L. Gallon, J. Miller, J. Levitsky.

    Surgery - Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL.

    Everolimus (EVL) is a modified form of the mTOR-inhibitor Sirolimus (SRL) and is used clinically in combination with Mycophenolate (MMF) and/or Tacrolimus (TAC). The purpose…
  • 2015 American Transplant Congress

    Hepatic Stellate Cells Inhibit T Cells Through Active TGFβ1 from a Cell-Surface-Bound Latent TGFβ1/GARP Complex

    Y. Li, B.-G. Kim, S. Qian, J. Letterio, J. Fung, L. Lu, F. Lin.

    Immunology, Lerner Research Institute, Cleveland Clinic; 2Pediatric Hematology-Oncology, Case Western Reserve University; 3General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.

    Nonparenchymal cells appear to be critical to maintain the immunoprivileged status of liver as whole liver allografts are well-tolerated in mice, but allo-hepatocytes are rapidly…
  • 2015 American Transplant Congress

    Iron Deficiency Impairs Regulatory T Cell Induction

    R. Danger,1 E. Bonaccorsi-Riani,1 E. Kodela,1 H. Collins,2 R. Hider,3 M. Martínez-Llordella,1 A. Sánchez-Fueyo.1

    1Department of Liver Sciences, Faculty of Life Sciences & Medicine, MRC Transplant Centre, King's College London, London, United Kingdom; 2Department of Immunology, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom; 3Institute of Pharmaceutical Science, King's College London, London, United Kingdom.

    In a recent clinical trial of immunosuppression withdrawal in adult liver transplant recipients, operational tolerance was associated with development of a transient lymphocyte infiltration rich…
  • 2015 American Transplant Congress

    TGFβ Production By B Cells Is Critical for Transplant Tolerance Induction

    J. Kim,1 W. Liu,1,2 L. Liu,1,2 K. Lee,1 R. Stott,1 H. Yeh,1 J. Markmann.1

    1Surgery, Massachusetts General Hospital / Harvard Medical School, Boston, MA; 2Surgery, Chengdu Military General Hospital, Chengdu, Sichuan, China.

    Regulatory B cells (Bregs) have been shown to play a critical role in immune homeostasis and in autoimmunity models. We have recently demonstrated that combined…
  • 2015 American Transplant Congress

    B-Cell Tolerance to Donor Alloantigens

    A. Patil, M. Climov, A. Matar, A. Musa, E. Harrington, D. Sachs, R. Duran-Struuck, C. Huang.

    Department of Surgery, Transplantation Biology Research Center, Massachusetts General Hospital, Boston, MA.

    Pre-existing panel-reactive antibodies and development of donor-specific alloantibodies are known to play important roles in graft dysfunction and deterioration. Preventing and/or eliminating alloantibody responses would…
  • 2015 American Transplant Congress

    Cell Type of the Tolerizing Inoculum Plays a Role in the Formation of of Molecular Chimerism in Murine Neonatal Tolerance

    X. Wang,1 H. Mewhort,1 S. Wang,1 S. Tollenaar,1 K. Tao,1 L. West.1,2,3

    1Department of Pediatrics, University of Alberta, Edmonton, AB, Canada; 2Department of Surgery, University of Alberta, Edmonton, AB, Canada; 3Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada.

    Background: Heart transplantation is a lifesaving measure for many infants with severe congenital heart diseases. The acceptance of cardiac allografts without immunosuppression, or operational tolerance,…
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