2015 American Transplant Congress
Immune Reconstitution in Recipients of Living Donor Kidney/Hematopoietic Stem + Facilitating Cell Transplants
We report the long-term results from a reduced-intensity nonmyeloablative conditioning approach to establish high levels of donor chimerism without graft-versus-host disease (GVHD) in mismatched related…2015 American Transplant Congress
An Economic Analysis of Tolerance Induction for Two-Haplotype Match Kidney Living Donor Transplant Recipients
1Medicine, Stanford University, Palo Alto, CA; 2Medicine, Baylor College of Medicine, Houston, TX.
Purpose:Tolerance induction is a novel therapy that enables some living donor kidney transplant recipients (LDKTR) to safely discontinue immunosuppressive (IS) therapy. We examine whether tolerance…2015 American Transplant Congress
Peritransplant Costimulation Blockade and Rapamycin Therapy Induces Permanent Limb Allograft Survival
Aim: Using murine models, we sought to identify the mechanisms of responsible for vascularized composite allotransplant (VCA) rejection, and to thereafter, using clinically relevant peri-transplant…2015 American Transplant Congress
IL-33 Enhances Host Tolerance to Candida albicans Kidney Infections Through Induction of IL-13 Production by CD4+ T Cells
Susceptibility to systemic Candida albicans infection is determined not only by immune resistance but also by the ability to control Candida-induced immunopathologies. We previously showed…2015 American Transplant Congress
Eomesodermin Expression By Alloreactive Non-Human Primate CD8+ Memory T Cells: Influence of CTLA4Ig and Regulatory DC Infusion in Renal Allograft Recipients
Background:Memory T cells (Tmem), particularly those resistant to costimulation blockade (CoSB), are considered a major barrier to transplant tolerance. The T-box transcription factor Eomesodermin (Eomes)…2015 American Transplant Congress
Changes in Health Related Quality of Life (HRQOL) in Pediatric Liver Transplant (LT) Recipients During Protocolized Immunosuppression Withdrawal (ISW): The iWITH Trial
ISW may limit medication-related comorbidities but intensive monitoring and unexpected rejection episodes may compromise HRQOL. We studied longitudinal HRQOL in pediatric LT recipients undergoing ISW…2015 American Transplant Congress
Identifying the “Operational Tolerant” Pediatric Liver Transplant Recipient by Cytometry by Time-of-Flight
Liver allografts are known to be well tolerated and indeed, some recipients of liver allografts retain stable graft function in the absence of immunosuppression. The…2015 American Transplant Congress
Vascularized Bone Marrow Plays a Critical Role in Inducing Tolerance of Osteomyocutaneous Allografts
Background: Vascularized composite allograft (VCA) that includes medullary bone may provide proposed benefits ofvascularized bone marrow transplantation (VBMT), such as a continuous supply of donor…2015 American Transplant Congress
A Novel Post-Transplant High-Dose Cyclophosphamide-Based Regimen to Promote Immune Tolerance After VCA
Background: VCA has become a viable treatment option for devastating tissue defects. However, the life-long need of immunosuppressive medications curtails the wider use of VCA.…2015 American Transplant Congress
Identification of miRNAs Associated With Induced Tolerance to Allografts
Surgery-Transplantation, Stanford University School of Medicine, Stanford, CA.
Introduction: Although the liver is less immunogenic than other solid organs, most liver transplant recipients receive lifelong immunosuppression. Total lymphoid irradiation (TLI) is part of…
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