Articles tagged "Tolerance"

2016 American Transplant Congress
Combination of Veto Cell Transfer and iNKT Cell Therapy Establishes Complete Hematopoietic Chimerism in Non-Myeloablative BMT Recipients.
R. Ishii,¹ T. Hirai,¹ Y. Ishii,² K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Laboratory for Vaccine Design, RIKEN IMS-RCAI, Yokohama, Japan.
Hematopoietic chimerism after non-myeloablative bone marrow transplantation (nmBMT) has been found beneficial for establishment of transplant tolerance. Since bone marrow cells (BMCs) are endowed with…
2016 American Transplant Congress
Distinct Effects of Chronic Hyperglycemia on Cellular and Humoral Alloresponses In Vivo.
N. Bishop,¹ K. Beard,² R. Gill.²
¹Immunology and Microbiology, University of Colorado Denver, Aurora, CO; ²Surgery, University of Colorado Denver, Aurora, CO; ³Surgery, University of Colorado Denver, Aurora, CO.
Background: Diabetes constitutes a significant problem in the transplant recipient. Diabetes is associated with impaired immunity to pathogens but its effect on alloimmunity remains ambiguous.…
2016 American Transplant Congress
In Vitro and In Vivo Characterization of Human Hematopoietic Chimeric Cells – A Novel Approach for Tolerance Induction in Transplantation.
M. Siemionow, E. Tfaily, M. Cyran, R. Gendek, M. Strojny, E. Szilagyi, J. Cwykiel.
Department of Orthopaedics, University of Illinois at Chicago, Chicago, IL.
Background: Cell-based therapies represent a new promising approach for tolerance induction in transplantation. One of the methods for immune response modulation in solid organ and…
2016 American Transplant Congress
Early Post-Transplant Immunosuppression (IS) Withdrawal – Final Outcomes of the ITN030ST AWISH Study.
A. Shaked,¹ S. Feng,² J. Punch,³ J. Reyes,⁴ J. Levitsky,⁵ G. Klintmalm,⁶ H. Kopetskie,⁷ M. DesMarais,² A. Priore,⁸ N. Bridges,⁸ P. Sayre.²
¹UPenn, Philadelphia; ²UCSF, San Francisco; ³U Michigan, Ann Arbor; ⁴U Washington, Seattle; ⁵Northwestern, Chicago; ⁶Baylor, Dallas; ⁷RhoFed, Chapel Hill; ⁸NIAID, Bethesda.
ITN030ST is a prospective randomized trial designed to determine the clinical benefit of early IS withdrawal in adult liver transplant (LT) recipients. Recipients did not…
2016 American Transplant Congress
Receptor Tyrosine Kinase Mer Mediates Expansion of MDSCs Critical for Transplantation Tolerance.
L. Zhang,¹ M. DeBerge,² X. Zhang,³ J. Wang,³ Z. Zhang,³ E. Thorp,² X. Luo.^1,2,3
¹Medicine, Northwestern University, Chicago, IL; ²Microbiology and Immunology, Northwestern University, Chicago, IL; ³Comprehensive Transplant Center, Northwestern University, Chicago, IL.
Introduction: The TAM (Tyro3, Axl and Mer) receptor tyrosine kinases (RTKs) mediate homeostatic phagocytosis of apoptotic cells, and transmit regulatory signals that modulate immune response.…
2016 American Transplant Congress
Post Transplantation High-Dose Cyclophosphamide Treatment Promotes Immune Tolerance After Skin, Solid Organ, and Vascularized Composite Allotransplantation.
G. Furtmüller,¹ B. Oh,¹ M. Fryer,^1,4 P. Akre,¹ S. Ganguly,² J. Dodd-o,³ D. Cooney,¹ G. Raimondi,¹ W. Lee,¹ L. Luznik,² G. Brandacher.¹
¹Department of Plastic and Reconstructive Surgery, Johns Hopkins Medicine, Baltimore, MD; ²Immunology - Sydney Kimmel Cancer Center, Johns Hopkins Medicine, Baltimore, MD; ³Department of Anesthesiology, Johns Hopkins Medicine, Baltimore, MD; ⁴Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA.
Background: Developing novel approaches to minimize/avoid immunosuppression by induction of immune tolerance represents the prime task in the field of transplantation. Methods: Murine skin, heart,…
2016 American Transplant Congress
Eomesodermin Expression by CD8+ Alloreactive T Cells in Human and Nonhuman Primate Allograft Recipients.
A. Perez-Gutierrez, L. Lu, A. Zahorchak, Y. Ono, A. Thomson, M. Ezzelarab.
Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
Background:The transcription factor Eomesodermin (Eomes) is critical in the maintenance of antigen-specific memory T cells (Tmem). We have shown previously that prolonged kidney allograft survival…
2016 American Transplant Congress
Inflammatory Conditions Switch the Effect of MSC on B Cells from Pro-Tolerogenic to Anti-Proliferative.
M. Franquesa,^1,2 F. Luk,¹ S. Korevaar,¹ L. Boon,³ F. Borras,² M. Betjes,¹ C. Baan,¹ M. Hoogduijn.¹
¹Transplantation and Nephrology Lab, Internal Medicine, Erasmus MC, Rotterdam, Netherlands; ²IVECAT, Nephrology Department, IGTP, Badalona, Spain; ³Bioceros, Utrecht, Netherlands.
The immunomodulatory capacity of mesenchymal stem cells (MSC) makes them a promising therapeutic tool in transplantation. MSC are recently gaining interest for their immunomodulatory effects…
2016 American Transplant Congress
Primary Outcome of iWITH: A Multi-Center Clinical Trial of Complete Immunosuppression Withdrawal (ISW) in Stable Pediatric Liver Transplant (LT) Recipients.
S. Feng,¹ J. Bucuvalas,² A. Demetris,³ K. Spain,⁴ S. Kanaparthi,⁵ J. Magee,⁶ G. Mazariegos,³ The iWITH Investigators.⁷
¹UCSF, San Francisco; ²CCHMC, Cincinnati; ³U Pitt, Pittsburgh; ⁴Rho, Chapel Hill; ⁵ITN, Bethesda; ⁶U Mich, Ann Arbor; ⁷NIAID/NIDDK/ITN, Bethesda.
AIM: Test the hypothesis that a selected cohort of pediatric LT recipients can safely undergo complete ISW followed by assessment for operational tolerance (OT)METHODS: 88…
2016 American Transplant Congress
NK Cells Are Required in B-Cell Dependent, Antibody Mediated Islet Transplant Tolerance.
C. Schuetz, K. Lee, L. Kojima, L. Washburn, L. Liu, W.-H. Liu, J. Kim, J. Markmann.
Dept of Surgery, Transplant Surgery Division, Massachusetts General Hospital, Boston, MA.
Immunologic tolerance to islets has been achieved in various rodent models using antibodies directed at CD45RB and Tim-1. We have shown that this tolerance mechanism…