Articles tagged "Tolerance"

2016 American Transplant Congress
The Effects of Brain Death and Ischemia on Tolerance Induction Are Organ-Specific.
S. Michel,^1,2 M. Madariaga,¹ G. LaMuraglia II,¹ R. Colvin,³ E. Farkash,³ J. Allan,^1,4 D. Sachs,¹ K. Yamada,¹ J. Madsen.^1,5
¹Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ²Department of Cardiac Surgery, Ludwig-Maximilians-University, Munich, Germany; ³Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁴Division of Thoracic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁵Division of Cardiac Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Background. We have previously shown that 12 days of high-dose calcineurin inhibition induced tolerance in miniature swine transplanted with MHC mismatched lung or cotransplanted heart…
2016 American Transplant Congress
The UK ONE Study: Safety and Feasibility of Regulatory T Cell Therapy in Renal Transplantation.
A. Bushell,¹ J. van der Net,^1,2 D. Game,³ R. Hilton,³ S. Thirkell,⁴ P. Friend,² E. Geissler,⁵ K. Wood,¹ P. Harden,² G. Lombardi.⁴
¹Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ²Oxford Transplant Centre, Oxford, United Kingdom; ³Guy's Hospital, London, United Kingdom; ⁴Immunoregulation Laboratory, King's College London, Guy's Hospital, London, United Kingdom; ⁵Department of Surgery, University Hospital Regensburg, Regensburg, Germany.
Introduction: The UK ONE Study trial investigates the safety and feasibility of regulatory T (Treg) cell therapy in renal transplantation.Materials and Methods: Eleven (9m;2f) living…
2016 American Transplant Congress
Ageing as a Barrier to Transplant Tolerance.
J. Kim, R. Stott, H. Deirawan, L. Kojima, L. Washburn, G. Zhao, H. Yeh, J. Markmann.
Surgery/Transplant, Massachusetts General Hospital, Harvard Medical, Boston, MA.
We recently demonstrated that ageing also impedes development of transplantation tolerance. Unlike their young counterparts (8-12 weeks of age) aged male recipients (greater than 12…
2016 American Transplant Congress
C5a Induces CSF1-Dependent Regulatory Macrophage (Mreg) Development Required for Murine Allograft Tolerance.
I. Llaudo, P. Conde, J. Ochando, P. Heeger.
Icahn School of Medicine at Mount Sinai, New York, NY.
Anti-CD40L (MR1) induced heart transplant tolerance has been recently shown to be dependent on early post-transplant intragraft accumulation of CD11b+Ly6CLoLy6G- DC-SIGN expressing Mreg that develop…
2016 American Transplant Congress
Developing a PCR-Based System to Access the Correlation of Local Chimerism and Fate of the Vascularized Composite Allotransplant.
X.-T. Huang,¹ H.-Y. Cheng,¹ C.-F. Lin,¹ S.-S. Qiu,² L.-Y. Shih,¹ F.-C. Wei.^1,2,3
¹Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Gueishan, Taoyuan, Taiwan; ²Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Gueishan, Taoyuan, Taiwan; ³College of Medicine, Chang Gung University, Gueishan, Taoyuan, Taiwan.
It is established that development of mixed chimerism following allotransplantation is associated with induction of tolerance to allotransplants. Although chimerism in peripheral blood can be…
2016 American Transplant Congress
The Function of CD8⁺TCR^– Facilitating Cells and Regulatory T Cells Is Impaired in Flt3-Ligand Knockout Mice.
Y. Huang, H. Xu, T. Miller, Y. Wen, S. Ildstad.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
Graft CD8+TCR- facilitating cells (FC) enhance engraftment of hematopoietic stem cells (HSC) in allogeneic mouse recipients without causing graft-versus-host disease. FC induce antigen-specific CD4+CD25+FoxP3+ regulatory…
2016 American Transplant Congress
Impact of Mixed Xenogeneic Porcine Hematopoietic Chimerism on Human NK Cell Recognition in a Humanized Mouse Model.
H. Li,¹ P. Vishwasrao,^1,2 M. Holzl,¹ S. Chen,¹ G. Choi,^2,3 G. Zhao,¹ M. Sykes.¹
¹Columbia Center for Translational Immunology, Columbia University, New York, NY; ²Department of Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands; ³Department of Hematology, University Medical Center Groningen, Groningen, Netherlands.
Xenotransplantation is a potential solution for the shortage of organs for transplantation. However, potent xenograft rejection responses present a formidable barrier. Mixed xenogeneic hematopoietic chimerism…
2016 American Transplant Congress
Enhanced IL-6 Production Impedes Transplant Tolerance Induction in Lupus-Prone Mice.
B. Stocks, C. Wilson, M. Seto, A. Marshall, D. Moore.
Pediatrics and Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN.
Significance: Autoimmunity is a significant barrier to transplantation. Based on previous studies, it is apparent that there are separate genetic regions that control susceptibility to…
2016 American Transplant Congress
Modification of DC Phenotype and Function via Targeted Porous Silicon Nanoparticles.
S. Stead,¹ S. McInnes,² S. Kireta,³ P. Rose,¹ D. Rojas-Canales,³ S. Jesudason,³ S. Grey,⁴ R. Carroll,³ N. Voelcker,² P. Coates.^1,3
¹School of Medicine, University of Adelaide, Adelaide, Australia; ²Future Industries Institute, University of South Australia, Adelaide, Australia; ³CNARTS, Royal Adelaide Hospital, Adealide, Australia; ⁴Transplantation Immunology, Garvan Institute of Medical Research, Sydney, Australia.
Aims: Dendritic cells (DC) are the most potent antigen-presenting cell and are fundamental in the establishment of transplant tolerance. Targeting DC via the DC-SIGN receptor…
2016 American Transplant Congress
Membrane Proteome Profiling Reveals Molecular Changes Associated with Donor-Specific Tolerance to Vascularized Composite Allotransplants.
H.-Y. Cheng,¹ C.-L. Han,² F.-W. Jiang,² L.-Y. Shih,¹ C.-F. Lin,¹ Y.-J. Chen,³ F.-C. Wei.^1,4
¹Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Gueishan, Taoyuan, Taiwan; ²Master Program for Pharmacogenomics and Pharmacoproteomics, Taipei Medical University, Taipei, Taiwan; ³Institute of Chemistry, Academia Sinica, Taipei, Taiwan; ⁴College of Medicine, Chang Gung University, Gueishan, Taoyuan, Taiwan.
Background: although donor-specific tolerance to vascularized composite allotransplants (VCAs) has been successfully induced with different regimes, molecular changes associated with tolerance are not well understood.Materials…