2016 American Transplant Congress
Mechanistic Insights into How Targeting of HDAC10 Promotes Foxp3+ Treg Cell Suppressive Activity, Gene Expression and Metabolism, and Enhances Allograft Survival.
1Children's Hospital of Philadelphia, Philadelphia; 2University of Pennsylvania, Philadelphia.
Foxp3+ T-regulatory (Treg) cells are key regulators of immune responses that can result in unwarranted inflammation and promote allograft rejection. From a theoretical perspective, targeting…2016 American Transplant Congress
The Role of B Cells in Liver Transplant Tolerance.
Scarcely one would argue that donor-specific B cells and antibodies contribute to rejection of transplants. However, studies published in the past few years have provided…2016 American Transplant Congress
In Vitro Reactivity of CD4+ T Cells Subsets from Hosts with Antigen Specific Transplant Tolerance Mediated by CD4+CD25+T Cells.
Immune Tolerance Laboratory, UNSW Australia, Sydney, NSW, Australia.
In animals with transplant tolerance without lympho-hemopoietic chimerism peripheral T cells reactive to donor are not deleted, but their capacity to effect rejection is inhibited…2016 American Transplant Congress
Memory Regulatory T Cell: A Potential Actor in Immunological Operational Tolerance in Kidney-Transplant Patients via the ATP Degradation into Adenosine.
Regulatory T cells (Tregs) are essential actors in the control of self-tolerance and exacerbated inflammation. In experimental transplantation Tregs are critical to achieve alloantigen tolerance…2016 American Transplant Congress
αLFA-1 Monotherapy Induced Tolerance Is Dependent on Indirect CD8 T-Cells and Augments a Population of CD8 Cells with a Suppressor Phenotype.
We sought to investigate some of the requirements for tolerance induction to cardiac allografts utilizing αLFA-1 mAb monotherapy. Having previously demonstrated that CD8 T-cells are…2016 American Transplant Congress
Type-I Interferon Induced Cross-Competition of IL-10 Signaling and Its Role in the Abrogation of Transplant Tolerance.
Plastic Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD.
PurposeA growing body of evidence shows that induction of long term transplant survival by “costimulation blockade” (CoB) regimens is impaired by inflammatory responses. In particular,…2016 American Transplant Congress
End-Stage Renal Disease Does Not Impair the Large-Scale Generation of Potent Alloantigen-Specific Regulatory T Cells for Immunotherapy.
Background Alloantigen-specific natural occurring regulatory T cells (nTregs) have the potential to offer a more targeted approach of immunosuppression and are the cell type of…2016 American Transplant Congress
Impact of Mixed Xenogeneic Chimerism on Human B Cell Response to Pig Antigens.
Columbia Center for Translational Immunology, Columbia University, New York, NY.
Xenotransplantation is a potential solution to the organ shortage in clinical transplantation. Pigs are regarded as the most suitable donors. Studies in pig-to-nonhuman primates have…2016 American Transplant Congress
Genetic TIM-4 Deletion Promotes Immunoregulatory Tissue-Resident Macrophage Survival and Lowers the Barrier to Cardiac Allograft Tolerance.
We report that the CD169+TIM-4+ tissue-resident macrophage (TRM) subset is the dominant tissue-resident leukocyte in skin, heart, and pancreas from C57BL/6 mice and skin and…2016 American Transplant Congress
Role of Regulatory T Cells in Induction of Tolerance in Mouse Vascularized Osteomyocutaneous Allotransplantation Under Combined Costimulation Blockade.
Background: The role of regulatory T cells (Tregs) in allograft tolerance has been studied using various transplant models, but the mechanism in vascularized composite allotransplantation…
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