Articles tagged "Tolerance"

2016 American Transplant Congress
Tolerogenic Interactions Between Host CD8⁺Myeloid Dendritic Cells and Natural Killer T Cells Are Required for Acceptance of Combined Organ and Bone Marrow Transplants After TLI Conditioning.
D. Hongo Apum,¹ X. Zhang,² E. Engleman,² S. Strober.¹
¹Medicine - Division of Immunology & Rheumatology, Stanford University, Stanford, CA; ²Medicine - Department of Pathology, Stanford University, Stanford, CA.
Combined transplantation of solid organs and bone marrow or hematopoietic progenitor cells has resulted in successful achievement of tolerance in both laboratory animals and in…
2016 American Transplant Congress
Eomesodermin Expression by CD8+ Alloreactive T Cells in Human and Nonhuman Primate Allograft Recipients.
A. Perez-Gutierrez, L. Lu, A. Zahorchak, Y. Ono, A. Thomson, M. Ezzelarab.
Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
Background:The transcription factor Eomesodermin (Eomes) is critical in the maintenance of antigen-specific memory T cells (Tmem). We have shown previously that prolonged kidney allograft survival…
2016 American Transplant Congress
Inflammatory Conditions Switch the Effect of MSC on B Cells from Pro-Tolerogenic to Anti-Proliferative.
M. Franquesa,^1,2 F. Luk,¹ S. Korevaar,¹ L. Boon,³ F. Borras,² M. Betjes,¹ C. Baan,¹ M. Hoogduijn.¹
¹Transplantation and Nephrology Lab, Internal Medicine, Erasmus MC, Rotterdam, Netherlands; ²IVECAT, Nephrology Department, IGTP, Badalona, Spain; ³Bioceros, Utrecht, Netherlands.
The immunomodulatory capacity of mesenchymal stem cells (MSC) makes them a promising therapeutic tool in transplantation. MSC are recently gaining interest for their immunomodulatory effects…
2016 American Transplant Congress
Primary Outcome of iWITH: A Multi-Center Clinical Trial of Complete Immunosuppression Withdrawal (ISW) in Stable Pediatric Liver Transplant (LT) Recipients.
S. Feng,¹ J. Bucuvalas,² A. Demetris,³ K. Spain,⁴ S. Kanaparthi,⁵ J. Magee,⁶ G. Mazariegos,³ The iWITH Investigators.⁷
¹UCSF, San Francisco; ²CCHMC, Cincinnati; ³U Pitt, Pittsburgh; ⁴Rho, Chapel Hill; ⁵ITN, Bethesda; ⁶U Mich, Ann Arbor; ⁷NIAID/NIDDK/ITN, Bethesda.
AIM: Test the hypothesis that a selected cohort of pediatric LT recipients can safely undergo complete ISW followed by assessment for operational tolerance (OT)METHODS: 88…
2016 American Transplant Congress
Long-Lasting Skin Allograft Tolerance Induced and Maintained by Short-Term Vascularized Bone Marrow Transplant in a Mouse Model.
C.-H. Lin,¹ M. Anggelia,¹ H.-Y. Cheng,¹ Y.-L. Wang,¹ W.-Y. Chuang,¹ C.-H. Lin,¹ G. Brandacher.²
¹Center for Vascularized Composite Allotransplantation, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ²Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA) Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: Accumulating evidences indicate that vascularized bone marrow transplantation (VBMT) plays a critical role in inducing tolerance of vascularized composite allografts (VCA). Recipients with long-term…
2016 American Transplant Congress
Regulatory T Cell Infusion Can Enhance Memory T Cell and Alloantibody Responses in Lymphodepleted Nonhuman Primate Heart Allograft Recipients.
M. Ezzelarab,¹ H. Zhang,¹ L. Lu,¹ H. Guo,¹ A. Zahorchak,¹ R. Wiseman,² M. Nalesnik,³ J. Bhama,¹ D. Cooper,¹ A. Thomson.^1,4
¹Surgery, University of Pittsburgh, Starzl Institute, Pittsburgh, PA; ²Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI; ³Pathology, University of Pittsburgh, Pittsburgh, PA; ⁴Immunology, University of Pittsburgh, Pittsburgh, PA.
Background:The ability of regulatory T cells (Treg) to prolong allograft survival and promote transplant tolerance in lymphodepleted rodents is well-established. Few studies have addressed the…
2016 American Transplant Congress
ESAT-6 Inhibits Donor-Specific Memory CD8+ T Cell Generation and Alloimmune Responses.
Z. Dai,¹ H. Dai.²
¹Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China; ²University of Pittsburgh, Pittsburgh.
Inducing long-term transplant survival or tolerance without continuous global immunosuppression is a highly desired goal in organ transplantation because conventional immunosuppressive drugs usually cause severe…
2016 American Transplant Congress
Delaying the Induction of Mixed Chimerism Until Two Months After NHP Heart and Kidney Cotransplantation Results in Long Term Survival.
K. Huh,¹ M. Tonsho,¹ P. Spencer,¹ J. Paster,¹ X. Wu,¹ I. Hanekamp,¹ T. Kawai,^1,3 R. Smith,² A. Cosimi,¹ A. Dehnadi,¹ G. Benichou,¹ R. Colvin,^1,2 J. Madsen.^1,4
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Boston, MA; ³Department of Surgery, Massachusetts General Hospital, Boston, MA; ⁴Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA.
Background. We have previously achieved delayed tolerance in cynomologous recipients cotransplanted with heart and kidney allografts by treating recipients with standard triple drug immunosuppression for…
2016 American Transplant Congress
Seven Year Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients.
J. Leventhal,¹ J. Galvin,¹ D. Stare,¹ L. Gallon,¹ J. Miller,¹ J. Mathew,¹ M. Abecassis,¹ S. Ildstad.²
¹Northwestern University, Chicago; ²University of Louisville, Louisville.
36 subjects have been enrolled and 31 transplanted in a phase 2 protocol (IDE 13947) to induce tolerance in recipients of living donor renal allografts…
2016 American Transplant Congress
TGFb in Regulatory B Cells-Dependent Tolerance.
H. Deirawan, L. Kojima, L. Washburn, J. Markmann, J. Kim.
Surgery, Massachusetts General Hospital, Boston, MA.
In transplantation, increasing evidence support that B cells can play a major regulatory role in addition to their critical functions in allo-immunity and graft rejection.…