Articles tagged "Tolerance"

2016 American Transplant Congress
Impact of Mixed Xenogeneic Chimerism on Human B Cell Response to Pig Antigens.
H. Li, S. Shao, P. Vishwasrao, M. Holzl, M. Sykes.
Columbia Center for Translational Immunology, Columbia University, New York, NY.
Xenotransplantation is a potential solution to the organ shortage in clinical transplantation. Pigs are regarded as the most suitable donors. Studies in pig-to-nonhuman primates have…
2016 American Transplant Congress
Genetic TIM-4 Deletion Promotes Immunoregulatory Tissue-Resident Macrophage Survival and Lowers the Barrier to Cardiac Allograft Tolerance.
T. Thornley,¹ P. Kyriazis,¹ K. Agarwal,¹ Z. Fang,¹ L. Ma,¹ V. Chipashvili,¹ M. Koulmanda,^1,2 T. Strom.^1,2
¹Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA; ²Surgery, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA.
We report that the CD169+TIM-4+ tissue-resident macrophage (TRM) subset is the dominant tissue-resident leukocyte in skin, heart, and pancreas from C57BL/6 mice and skin and…
2016 American Transplant Congress
Role of Regulatory T Cells in Induction of Tolerance in Mouse Vascularized Osteomyocutaneous Allotransplantation Under Combined Costimulation Blockade.
M. Anggelia,¹ H.-Y. Cheng,¹ Y.-L. Wang,¹ W.-Y. Chuang,¹ C.-H. Lin,¹ G. Brandacher,² F.-C. Wei,¹ C.-H. Lin.¹
¹Center for Vascularized Composite Allotransplantation, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; ²Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA) Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: The role of regulatory T cells (Tregs) in allograft tolerance has been studied using various transplant models, but the mechanism in vascularized composite allotransplantation…
2016 American Transplant Congress
Pre-Transplant Infusion of Extracorporeal Photopheresis Treated Donor Splenocytes Leads to Long-Term Liver Allograft Survival and Donor Specific Tolerance in Rats.
X. Kang,¹ Y. Xie,² X. Yeap,² J. Wang,² J. Schneiderman,² Z. Zhang.²
¹Hepatopancreatobiliary Surgery, The Third Hospital of Jilin University, Changchun, Jilin, China; ²Comprehensive Transplant Center, Northwestern University Feinberg School of Medicin, Chicago, IL.
Extracorporeal photopheresis (ECP), a procedure that exposes isolated WBC to photoactivatable 8-methoxypsoralen and ultraviolet A radiation, is used clinically to treat patients with cutaneous T-cell…
2016 American Transplant Congress
In Vitro Induction of T Regulatory Cells by Multipotent Adult Progenitor Cells.
S. Stubblefield, N. Williams, A. Ting.
Regenerative Medicine, Athersys, Inc, Cleveland, OH.
There is increasing evidence that transplanted adult stemcells remain undifferentiated and often are cleared after a short time.However, these short-lived stem cells still promote recovery…
2016 American Transplant Congress
Function of Sertoli Cells in Regulating Allogeneic T Cell Differentiation into Treg and Th17 In Vitro.
L. Xie,¹ W. Jiang.²
¹Institute of Organ Transplantation, Tongji Hospital, HUST, Wuhan, China; ²Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China.
The testis as an immune-privileged site allows long-term survival of allogeneic and xenogeneic transplants. Testicular Sertoli cells (SCs) can confer local immunoprotection for cotransplanted cells…
2016 American Transplant Congress
Accepted Mouse Kidney Allografts Are Characterized by Widespread Nitrosylation.
I. Aljabban, B. Jiang, C. Yang, D. Ndishabandi, R. White, P. Russell, J. Madsen, R. Colvin, A. Alessandrini.
Center for Transplantation Sciences, Dept. of Surgery, Dept. of Pathology, Massachusetts General Hospital, Boston, MA.
Leukocytes can modulate the immune response through manipulation of amino acid metabolism. Research indicates that depletion of L-arginine and generation of nitric oxide (NO) suppresses…
2016 American Transplant Congress
Mechanisms of Alloantigen-Specific Regulation After Donor Specific Transfusion and Costimulatory Blockade in YFP-Foxp3/TdTomRed-Ebi3 Marker Mice.
Y. Tomita,¹ W. Bracamonte-Baran,¹ D. Vignali,² W. Burlingham.¹
¹Department of Surgery, Division of Transplantation, University of Wisconsin-Madison, Madison, WI; ²Department of Immunology, University of Pittsburgh, Pittsburgh.
Background: In mice, donor specific transfusion (DST) plus anti-CD40L costimulatory blockade (MR-1) treatment is a standard and successful protocol to induced donor-specific transplant tolerance. Hypothesis:…
2016 American Transplant Congress
Toll-Like Receptor (TLR) 9-Induced Resistance to Murine Cardiac Allograft Tolerance Is Dependent Upon C3a and C5a Receptor (C3aR/C5aR) Signaling.
J. Sheen, P. Heeger.
Translational Transplant Research Center, Department of Medicine and Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
TLR stimulation has been shown by others to prevent costimulatory blockade-induced allograft tolerance. Immune cell derived complement activation products C3a and C5a amplify inflammation, enhance…
2016 American Transplant Congress
Tolerance Induction in Vascularized Composite Allotransplantation with Peri-Transplant Combined Costimulation Blockade.
B. Oh,¹ G. Furtmüller,¹ M. Fryer,¹ J. Grahammer,² S. Schneeberger,² D. Cooney,¹ G. Raimondi,¹ G. Brandacher.¹
¹Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ²Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria.
[Background] Vascularized composite allotransplantation (VCA) is an emerging new era in transplant medicine and has become a valid therapeutic option after devastating tissue loss, such…