2017 American Transplant Congress
Targeting JAK-STAT Pathways with Tofacitinib Provides a Novel Approach for Conditioning in Allogeneic BMT Recipients.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY
Hematopoietic chimerism achieved by bone marrow transplantation (BMT) induces donor-specific tolerance to solid organ grafts. We previously demonstrated that by targeting recipient immune cells (T,…2017 American Transplant Congress
Chimerism-Related Allotolerance Is Induced by Exosome Acquisition and Reprogramming of Host Dendritic Cells.
Maternal microchimerism (MMc) has been associated with allo-specific graft tolerance in mice and humans. This tolerance is associated with membrane allo-antigen acquisition (mAAQ), which is…2017 American Transplant Congress
Ethylene Carbodiimide Fixed Donor Splenocytes Combined with α-1 Antitrypsin Induce Indefinite Donor Specific Protection to Mice Cardiac Allografts.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Peritransplant infusion of ethylene carbodiimide fixed donor splenocytes(ECDI-SPs) induces protection of islet and cardiac allografts. However, pro-inflammatory cytokine production during the peritransplantation period may negate…2017 American Transplant Congress
Identification of a Stable Gene Signature of Transplant Tolerance to Liver Allograft by Meta-Analysis.
Transplant tolerant to a liver graft display a specific blood cell transcriptional pattern but results from six different studies were not consistent, raising the question…2016 American Transplant Congress
The Role of B Cells in Liver Transplant Tolerance.
Scarcely one would argue that donor-specific B cells and antibodies contribute to rejection of transplants. However, studies published in the past few years have provided…2016 American Transplant Congress
In Vitro Reactivity of CD4+ T Cells Subsets from Hosts with Antigen Specific Transplant Tolerance Mediated by CD4+CD25+T Cells.
Immune Tolerance Laboratory, UNSW Australia, Sydney, NSW, Australia.
In animals with transplant tolerance without lympho-hemopoietic chimerism peripheral T cells reactive to donor are not deleted, but their capacity to effect rejection is inhibited…2016 American Transplant Congress
Memory Regulatory T Cell: A Potential Actor in Immunological Operational Tolerance in Kidney-Transplant Patients via the ATP Degradation into Adenosine.
Regulatory T cells (Tregs) are essential actors in the control of self-tolerance and exacerbated inflammation. In experimental transplantation Tregs are critical to achieve alloantigen tolerance…2016 American Transplant Congress
αLFA-1 Monotherapy Induced Tolerance Is Dependent on Indirect CD8 T-Cells and Augments a Population of CD8 Cells with a Suppressor Phenotype.
We sought to investigate some of the requirements for tolerance induction to cardiac allografts utilizing αLFA-1 mAb monotherapy. Having previously demonstrated that CD8 T-cells are…2016 American Transplant Congress
Type-I Interferon Induced Cross-Competition of IL-10 Signaling and Its Role in the Abrogation of Transplant Tolerance.
Plastic Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD.
PurposeA growing body of evidence shows that induction of long term transplant survival by “costimulation blockade” (CoB) regimens is impaired by inflammatory responses. In particular,…2016 American Transplant Congress
End-Stage Renal Disease Does Not Impair the Large-Scale Generation of Potent Alloantigen-Specific Regulatory T Cells for Immunotherapy.
Background Alloantigen-specific natural occurring regulatory T cells (nTregs) have the potential to offer a more targeted approach of immunosuppression and are the cell type of…
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