Articles tagged "Tolerance"

2017 American Transplant Congress
IgM Immunotherapy Restores Immune Homeostasis in Type 1 Diabetes.
P. Chhabra,¹ C. Wilson,² D. Moore,² K. Brayman.¹
¹Surgery, University of Virginia, Charlottesville, VA; ²Pediatric Endocrinology, Vanderbilt University, Nashville, TN
Goal: To determine the mechanism(s) by which IgM immunotherapy restores immune homeostasis in Type 1 Diabetes (T1D).Background: IgM immunotherapy prevents the onset and progression of…
2017 American Transplant Congress
Transient High Dose Tacrolimus Allows Tolerance of a Vascularized Composite Allograft Tolerance Across a Full MHC Mismatch.
A. Leto Barone, H. Wang, E. Swanson, K. Kolegraff, J. Lopez, G. Furtmüller, B. Oh, S. Alfadil, S. Mermulla, J. Sacks, S. Bonawitz, G. Raimondi, J. Shores, D. Cooney, W. Lee, G. Brandacher.
Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, MD
Purpose: The achievement of tolerance in Vascularized composite allografts (VCA) could avoid the risks of immunosuppression in this setting. We investigated strategies for tolerance induction…
2017 American Transplant Congress
Aryl Hydrocarbon Receptor Regulates Myeloid Derived Suppressor Cells by Activating the ERK Signaling in a Murine Cardiac Transplantation Model.
T. Nakamura, K. Masuda, N. Yoshimura.
Department of Organ Transplantation and General Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
There is a growing evidence that Myeloid-derived suppressor cells (MDSCs) have a crucial role in organ transplantation; however, the detail condition where MDSCs are sufficiently…
2017 American Transplant Congress
Depletion of T-Cells from G-CSF Mobilized Human PBMC Prevents Acute GVHD in NSG Mice.
Y. Huang, H. Xu, A. Merchak, A. Chhabra, Y. Wen, L. Kahn, S. Ildstad.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY
Allogeneic HSC transplantation is commonly utilized for the treatment of hematologic malignancies and autoimmune diseases. However, allogeneic HSC transplantation is limited by potential for the…
2016 American Transplant Congress
ESAT-6 Inhibits Donor-Specific Memory CD8+ T Cell Generation and Alloimmune Responses.
Z. Dai,¹ H. Dai.²
¹Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China; ²University of Pittsburgh, Pittsburgh.
Inducing long-term transplant survival or tolerance without continuous global immunosuppression is a highly desired goal in organ transplantation because conventional immunosuppressive drugs usually cause severe…
2016 American Transplant Congress
Delaying the Induction of Mixed Chimerism Until Two Months After NHP Heart and Kidney Cotransplantation Results in Long Term Survival.
K. Huh,¹ M. Tonsho,¹ P. Spencer,¹ J. Paster,¹ X. Wu,¹ I. Hanekamp,¹ T. Kawai,^1,3 R. Smith,² A. Cosimi,¹ A. Dehnadi,¹ G. Benichou,¹ R. Colvin,^1,2 J. Madsen.^1,4
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Boston, MA; ³Department of Surgery, Massachusetts General Hospital, Boston, MA; ⁴Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA.
Background. We have previously achieved delayed tolerance in cynomologous recipients cotransplanted with heart and kidney allografts by treating recipients with standard triple drug immunosuppression for…
2016 American Transplant Congress
Seven Year Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients.
J. Leventhal,¹ J. Galvin,¹ D. Stare,¹ L. Gallon,¹ J. Miller,¹ J. Mathew,¹ M. Abecassis,¹ S. Ildstad.²
¹Northwestern University, Chicago; ²University of Louisville, Louisville.
36 subjects have been enrolled and 31 transplanted in a phase 2 protocol (IDE 13947) to induce tolerance in recipients of living donor renal allografts…
2016 American Transplant Congress
Long-Lasting Skin Allograft Tolerance Induced and Maintained by Short-Term Vascularized Bone Marrow Transplant in a Mouse Model.
C.-H. Lin,¹ M. Anggelia,¹ H.-Y. Cheng,¹ Y.-L. Wang,¹ W.-Y. Chuang,¹ C.-H. Lin,¹ G. Brandacher.²
¹Center for Vascularized Composite Allotransplantation, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ²Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA) Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: Accumulating evidences indicate that vascularized bone marrow transplantation (VBMT) plays a critical role in inducing tolerance of vascularized composite allografts (VCA). Recipients with long-term…
2016 American Transplant Congress
Regulatory T Cell Infusion Can Enhance Memory T Cell and Alloantibody Responses in Lymphodepleted Nonhuman Primate Heart Allograft Recipients.
M. Ezzelarab,¹ H. Zhang,¹ L. Lu,¹ H. Guo,¹ A. Zahorchak,¹ R. Wiseman,² M. Nalesnik,³ J. Bhama,¹ D. Cooper,¹ A. Thomson.^1,4
¹Surgery, University of Pittsburgh, Starzl Institute, Pittsburgh, PA; ²Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI; ³Pathology, University of Pittsburgh, Pittsburgh, PA; ⁴Immunology, University of Pittsburgh, Pittsburgh, PA.
Background:The ability of regulatory T cells (Treg) to prolong allograft survival and promote transplant tolerance in lymphodepleted rodents is well-established. Few studies have addressed the…
2016 American Transplant Congress
Anti-BTLA Antibody (6B2) Induced Prolongation of Fully MHC-Mismatched Murine Cardiac Allograft and Generation of Foxp3+ Regulatory T Cells.
M. Uchiyama,^1,2 E. Yin,^2,3 X. Jin,^2,4 T. Shimokawa,¹ H. Yagita,⁵ M. Niimi.²
¹Cardiovascular Surgery, Teikyo University, Tokyo, Japan; ²Surgery, Teikyo University, Tokyo, Japan; ³Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China; ⁴Thoracic Surgery, The 3rd Affiliated Hospital of Harbin Medical University, Harbin, China; ⁵Immunology, Juntendo University Hospital, Tokyo, Japan.
Background: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) has been implicated in the regulation of autoimmune and may potentially play an important…