Articles tagged "Tolerance"

2017 American Transplant Congress
Potential Mechanism Involving Regulatory T Cells in Induction of Tolerance in Mouse Vascularized Composite Allotransplantation Under Combined Costimulation Blockade.
M. Anggelia,^1,2 Y.-Y. Huang,³ W.-Y. Chuang,⁴ H.-Y. Cheng,¹ G. Brandacher,⁵ F.-C. Wei,^1,2 C.-H. Lin.^1,2
¹PRS, Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ²Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan; ³Nephrology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁴Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁵Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD
Background: Role of Regulatory T cells in vascularized composite allotransplantation (VCA) remains to be elucidated. In this study, we investigate potential mechanism involved in Tregs…
2017 American Transplant Congress
Novel Cell Intrinsic Role of the Adaptor Protein TSAd in Maintaining Alloimmune T Regulatory Cell Function.
J. Wedel,^1,2 M. Stack,^1,2 T. Seto,^1,2 M. Sheehan,^1,2 K. Liu,^1,2 E. Flynn,^1,2 D. Briscoe.^1,2
¹Transplant Research Program, Boston Children's Hospital, Boston; ²Department of Pediatrics, Harvard Medical School, Boston
TSAd is an SH2 domain containing intracellular adapter molecule that functions to elicit T cell receptor-mediated signals and cytokine production. TSAd knockout (KO) T cells…
2017 American Transplant Congress
mRNA Biomarkers in Renal Allograft Protocol Biopsies Detected by the Nanostring Platform Predict Tolerance in Non-Human Primates.
M. Matsunami,¹ T. Oura,¹ I. Rosales,² R.-N. Smith,² B. Adam,³ M. Mengel,³ A. Cosimi,¹ R. Colvin,² T. Kawai.¹
¹Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ³Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
Background. Renal allograft tolerance has been achieved in some but not all MHC mismatched kidneys in non-human primates (NHPs) and humans after induction of transient…
2017 American Transplant Congress
Differential Effect of Antibody Removal on ABO Blood Group Type Chain Specific Antibodies Over Time.
A. Bentall,¹ M. Jeyakanthan,² J. Pearcey,² B. Motyka,² C. Cairo,³ T. Lowary,³ J. Buriak,⁴ L. West,² S. Ball.¹
¹Department of Nephrology, University Hospital Birmingham, Birmingham, United Kingdom; ²Departs of Pediatrics, Surgery and Immunology, University of Alberta, Alberta Transplant Institute, Edmonton, Canada; ³Alberta Glycomics Centre, Univ of Alberta, Dept of Chemistry, Edmonton, Canada; ⁴Dept of Chemistry, National Institute of Nanotechnology, Edmonton, Canada
Introduction: The trisaccharide epitope defines A&B blood group antigens where antibody binds to subtype chains (I-VI), but only subtype II is expressed on cardiac vascular…
2017 American Transplant Congress
Liver Targeted Expression of a Single Allogeneic MHC I Molecule Promotes Tolerance to Pancreatic Islet Allograft by Inducing Specific CD8+ Regulatory T Cells in Mice.
V. Le Guen,^1,2 J.-P. Judor,^1,2 V. Gauttier,^1,2 N. Ferry,³ J.-P. Soulillou,^1,2 S. Brouard,^1,2 S. Conchon.^1,2
¹Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France; ²Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France; ³Département de Thérapie Cellulaire, CHU Saint Louis, Paris, France
A. Induction of donor-specific immune tolerance is a good alternative to chronic life-long immunosuppression for transplant patients. Donor major histocompatibility complex (MHC) molecules represent the…
2017 American Transplant Congress
Alloimmune Quiescence in Recipients with Long-Term Surviving Kidney Grafts.
K. Brown,¹ W. Baldwin,¹ E. Poggio,² W. Braun,² R. Fairchild.¹
¹Department of Immunology, Cleveland Clinic, Cleveland, OH; ²Nephrology and Glickman Urological Institue, Cleveland Clinic, Cleveland, OH
Recent studies of tolerant kidney transplant patients have identified increased numbers of circulating B cells expressing an immature/transitional phenotype (IgD+CD27-/IgD+CD27-CD24+CD38+). Similar frequencies of these immature/transitional…
2017 American Transplant Congress
The Gut Microbiota Regulates Murine Cardiac Transplant Outcome.
Y. Xiong, C. Brinkman, L. Hittle, W. Fricke, E. Mongodin, J. Bromberg.
UMB, Baltimore
Background: Gut microbiota regulates systemic immunity and can activate pro- or anti-inflammatory pathways. We hypothesized that the gut microbiota influences the survival of mismatched murine…
2017 American Transplant Congress
Maximizing the Potential of Treg-Based Therapies for Transplant Rejection via Computational Immune-Modeling: Effect of Dose, Timing, and Distribution.
G. Raimondi,¹ A. Arun,¹ O. Dorabiala,² J. Arciero.³
¹Plastic & Reconstructive Surgery, Johns Hopkins University, Baltimore; ²Mathematics, Pennsylvania State University, Philadelphia; ³Mathematical Sciences, Indiana University-Purdue University Indianapolis, Indianapolis
Purpose. Regulatory T cells (Treg), endogenous regulators of the immune system, have a significant therapeutic potential for prevention of transplant rejection. Experimental evidences however, indicate…
2017 American Transplant Congress
Validation of CYP4F11 as a Marker of Accommodation in Biopsies from Recipients of an ABO-Incompatible Renal Transplant.
K. Dominy,¹ M. Willicombe,³ T. Al Johani,² J. Galliford,³ A. McLean,³ T. Cook,³ C. Roufosse.³
¹Centre for Complement and Inflammation Research, Imperial College, London, United Kingdom; ²King Saud University, Riyadh, Saudi Arabia; ³Imperial College Healthcare NHS Trust, London, United Kingdom
Recipients of an ABO incompatible transplant have circulating anti-AB antibodies, A and/or B antigens expressed on endothelium and usually C4d deposition on the endothelium, yet…
2017 American Transplant Congress
Blood Tfh Cells Exhibit Impaired B Cell Help in Operationally Tolerant Patients.
R. Danger,¹ A. Chenouard,¹ M. Chesneau,¹ S. Castagnet,² P. Guérif,¹ N. Degauque,¹ M. Giral,¹ S. Brouard.¹
¹Inserm UMR 1064, Nantes University Hospital, Nantes, France; ²HLA Laboratory, Etablissement Français du Sang, Nantes, France
Introduction: Operationally tolerant (TOL) patients display a defect of B cell differentiation, with a deficiency in circulating plasma cells secreting antibodies, which could partly contribute…