Articles tagged "Tolerance"

2022 American Transplant Congress
Novel Phenotype of Intragraft Endothelial Cells That Modulates CD4⁺ T Effector-Mediated Rejection
J. Wedel, K. Liu, T. Seto, S. Kong, D. M. Briscoe
Boston Children's Hospital, Boston, MA
*Purpose: Previous studies have suggested that early adoptive transfer of Teff into Rag KO mice bearing cardiac transplants results in acute rejection. However, if transfer…
2022 American Transplant Congress
Intrinsic DEPTOR Activity Modulates Treg Subset Differentiation
J. Wedel¹, M. Maslyar¹, B. Alsairafi¹, S. Kong², D. M. Briscoe¹
¹Transplant Research Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, ²Computational Health Informatics Program, Boston Children's Hospital, Harvard Medical School, Boston, MA
*Purpose: We have previously reported that DEPTOR activity within CD4+Foxp3+ Tregs increases immunomodulation following transplantation. DEPTOR functions by both stabilization of Foxp3 expression through epigenetic…
2022 American Transplant Congress
Belatacept Augments Mixed Chimerism in a Novel Nonhuman Primate Kidney Transplant Tolerance Induction Protocol
S. C. Kim, C. J. Little, J. H. Fechner, P. J. Chlebeck, J. Post, A. D'Alessandro, D. B. Kaufman
University of Wisconsin, Madison, WI
*Purpose: A novel protocol of antilymphocyte globulin (ATG), tomotherapy-based total lymphoid irradiation (TomoTLI), and adoptive cellular transfer was developed in a preclinical model of MHC-mismatched…
2022 American Transplant Congress
A Novel IL-2 Mutein Selectively Expands Regulatory T Cells and Prolongs Skin Graft Survival
O. Efe¹, T. J. Borges¹, R. B. Gassen¹, L. Morena¹, A. Al Jurdi¹, I. T. Lape¹, G. J. Bobcock², J. C. Madsen¹, L. V. Riella¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²Visterra, Inc., Waltham, MA
*Purpose: Promoting immune regulation through expansion of regulatory T cell (Treg) may allow immunosuppression minimization and improve long-term graft outcomes. Low-dose IL-2 is known to…
2022 American Transplant Congress
Phase I/ii Car-Treg Cell Therapy Clinical Trial To Induce Long-term Tolerance In Liver Transplant Patients
A. Sanchez-Fueyo¹, A. Taylor¹, D. Collin², C. Nathalie², S. Chris², M. Martinez-Llordella², N. Belmonte², I. McGill², D. Hartl²
¹King's College London, London, United Kingdom, ²Quell Therapeutics Ltd, London, United Kingdom
*Purpose: Life-long pharmacological immunosuppression (IS) is considered essential to prevent rejection following liver transplantation (LT), but is associated with significant side effects such as infections,…
2022 American Transplant Congress
Novel Role of CD74 in Regulatory T Cell Homeostasis and Function in Allo-Immune Response
Z. Solhjou¹, H. Zhang¹, N. Younis¹, J. Choi¹, C. Deban¹, A. Saad¹, A. Halawi¹, Z. Jing¹, R. Bucala², J. Azzi¹
¹Brigham and Women's Hospital, Boston, MA, ²Yale University School of Medicine, New Haven, CT
*Purpose: Identifying new molecular targets based on our understanding of the biology of the allo-immune response in the allograft microenvironment is critical to develop more…
2022 American Transplant Congress
Effector T Cells Potentiate Treg Migration to Allografts
H. Baydoun, M. Fathallah, A. Pena, B. Robinson, G. Camirand
Surgery and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: CD4+ regulatory T cells (Treg) maintain transplantation tolerance through the suppression of immunity in both secondary lymphoid organs and allografts. However, the signals promoting…
2022 American Transplant Congress
Successful Use of Anti-IL-6R Therapy to Achieve Cardiac Allograft Tolerance in Non-Human Primates
C. L. Miller, K. J. Ahrens, J. M. O, P. M. Patel, A. Dehnadi, T. Costa, M. Momodu, J. A. Morrissette, D. Muldoon, I. M. Hanekamp, J. S. Allan, G. Benichou, J. C. Madsen
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: In contrast to kidney allografts, attempts to achieve tolerance of isolated cardiac allografts in non-human primates (NHPs) using a mixed chimerism strategy have been…
2022 American Transplant Congress
Using mTOR Inhibitor Nanoimmunotherapy to Induce Cardiac Allograft Tolerance in Non-Human Primates
J. M. O¹, P. M. Patel², A. J. Teunissen³, C. L. Miller⁴, T. Costa¹, M. Momodu¹, D. Muldoon¹, A. Dehnadi¹, I. M. Hanekamp¹, V. Pothula⁵, R. Sanchez-Tarjuelo⁶, G. Prevot⁶, W. J. Mulder⁶, J. Allan⁷, J. Ochando⁸, J. Madsen⁹
¹MGH, Boston, MA, ²Emory University, Atlanta, GA, ³Icahn School of Medicine at Mount Sinai, New york, NY, ⁴Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ⁵Icahn School of Medicine at Mount Sinai, New York, NM, ⁶Icahn School of Medicine at Mount Sinai, New York, NY, ⁷Massachusetts General Hospital - Harvard Medical S, Marblehead, MA, ⁸Mount Sinai School of Med, New York, NY, ⁹Massachusetts General Hospital, Boston, MA
*Purpose: Though tolerance of kidney allografts has been consistently achieved using a mixed-chimerism model, cardiac allografts remain resistant to tolerance induction. Lipoprotein-based nanobiologics loaded with…
2022 American Transplant Congress
Delivery of Extracellular Matrix Targeted Regulatory T Cells by Novel Nanofiber Coatings for Transplantation Therapies
L. Gallon¹, J. K. Carrow², J. He¹, Y. Sambandam¹, X. Lai¹, J. Mathew¹, L. C. Palmer², J. R. Leventhal¹, Z. Zhang¹, S. I. Stupp²
¹Surgery - Transplant, Northwestern University, Chicago, IL, ²Simpson Querrey Institute, Northwestern University, Chicago, IL
*Purpose: Regulatory CD4+CD25+FOXP3+ T cells (Tregs) have been shown to induce tolerance in transplantation models and can mitigate transplant rejection or injury following ischemic reperfusion…