Articles tagged "Tolerance"

2017 American Transplant Congress
Targeting JAK-STAT Pathways with Tofacitinib Provides a Novel Approach for Conditioning in Allogeneic BMT Recipients.
H. Xu, A. Merchak, M. Xu, C. Mort, T. Dowling, L. Kahn, M. Binion, A. Chhabra, Y. Wen, Y. Huang, S. Ildstad.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY
Hematopoietic chimerism achieved by bone marrow transplantation (BMT) induces donor-specific tolerance to solid organ grafts. We previously demonstrated that by targeting recipient immune cells (T,…
2017 American Transplant Congress
Chimerism-Related Allotolerance Is Induced by Exosome Acquisition and Reprogramming of Host Dendritic Cells.
D. Lema,¹ W. Bracamonte-Baran,² E. Jankowska-Gan,¹ F. Claas,³ J. van Rood,³ A. Mulder,³ W. Burlingham.¹
¹Surgery - Transplant Division, University of Wisconsin-Madison, Madison, WI; ²Pathology, Division of Immunology, Johns Hopkins University, Baltimore, MD; ³Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands
Maternal microchimerism (MMc) has been associated with allo-specific graft tolerance in mice and humans. This tolerance is associated with membrane allo-antigen acquisition (mAAQ), which is…
2017 American Transplant Congress
Ethylene Carbodiimide Fixed Donor Splenocytes Combined with α-1 Antitrypsin Induce Indefinite Donor Specific Protection to Mice Cardiac Allografts.
G. Chen, X. Lai, L. Qiu, Y. Zhao, S. Yu, J. Zhang, L. Chen.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Peritransplant infusion of ethylene carbodiimide fixed donor splenocytes(ECDI-SPs) induces protection of islet and cardiac allografts. However, pro-inflammatory cytokine production during the peritransplantation period may negate…
2017 American Transplant Congress
Identification of a Stable Gene Signature of Transplant Tolerance to Liver Allograft by Meta-Analysis.
G. Gu, H. Hang, Q. Xia.
Department of Hepatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Transplant tolerant to a liver graft display a specific blood cell transcriptional pattern but results from six different studies were not consistent, raising the question…
2017 American Transplant Congress
Relationship Between Mixed Chimerism and Tolerance in HLA-Matched and -Mismatched Recipients of Kidney and Hematopoietic Cell Transplants.
S. Busque, J. Scandling, J. Shizuru, R. Lowsky, A. Shori, J. Kent, E. Engleman, S. Strober.
Stanford University, Stanford
Twenty-eight fully HLA-matched and 18 HLA haplotype- matched recipients were given combined kidney and hematopoietic cell transplants using a completely post-transplant conditioning regimen consisting of…
2017 American Transplant Congress
Vital Role of the CoREST Complex as a Master Regulator of Foxp3+ T-Regulatory Cell Gene Expression and Suppressive Function.
L. Wang,¹ A. Samanta,¹ M. Levine,¹ U. Beier,¹ R. Han,¹ J. Kalin,² E. Holson,³ P. Cole,² W. Hancock.¹
¹Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; ²Johns Hopkins University, Baltimore, MD; ³Broad Institute, Cambridge, MA
While the Foxp3 promoter and its three associated conserved non-coding sequence (CNS)/enhancer regions have received much attention, literally nothing is known of the contribution of…
2017 American Transplant Congress
Type-1 Interferon Impairs the Immunoregulatory Activity of IL-10: A Mechanism in the Abrogation of Transplant Tolerance.
M. Iglesias, A. Arun, B. Lam, W. Lee, G. Raimondi, G. Brandacher.
Plastic Surgery, Johns Hopkins University. School of Medicine, Baltimore, MD
PurposeA growing body of experimental evidence shows that engagement of toll like receptors (TLR) can abrogate or revert the tolerogenic effect of “costimulation blockade” in…
2017 American Transplant Congress
Operational Tolerance in Intestinal Transplantation: A Proven Possibility.
B. Houlihan,¹ P. Cha,^1,2 C. Cosentino,^1,2 J. Kaiser,^1,2 A. Shukla,¹ J. Hawksworth,^1,2 C. Matsumoto,¹ T. Fishbein,¹ A. Kroemer.¹
¹Transplant Department, Medstar Georgetown University Hospital, Washington, DC; ²Surgery, Walter Reed National Military Medical Center, Bethesda, MD
A The purpose of this study is to immunologically characterize the first operationally tolerant intestinal transplant (ITx) patient known to date.B Flow cytometry and rtPCR…
2017 American Transplant Congress
Liver Transplantation Tolerance Using Outbred Mice.
M. Morita,¹ C. Miller,² J. Fung,³ L. Lu,^1,2 S. Qian.^1,2
¹Immunology, Cleveland Clinic, Cleveland, OH; ²General Surgery, Cleveland Clinic, Cleveland, OH; ³University of Michigan, Chicago, MI
Success of organ transplantation currently depends on life-time immunosuppression, resulting in severe side effects. Induction of donor specific tolerance is ideal, which actually spontaneously occurs…
2017 American Transplant Congress
A Molecular Signature Characterized by Dominance of Negative Regulation over Cytotoxic Effectors in Tolerant Kidney Allograft Recipients.
J. Lee,¹ J. Leventhal,² C. Li,¹ A. Katapodis,³ S. Ildstad,⁴ M. Suthanthiran.¹
¹Medicine, Weill Cornell, NY, NY; ²Surgery, Northwestern Medicine, Chicago, IL; ³Novartis, Basel, Switzerland; ⁴Regenerex, Louisville, KY
Introduction. Development of tolerance biomarkers is important for interrogating the in-vivo immune status of patients entered in clinical trials of tolerance.Methods. To determine the feasibility…