Articles tagged "Tolerance"

2017 American Transplant Congress
Novel Cell Intrinsic Role of the Adaptor Protein TSAd in Maintaining Alloimmune T Regulatory Cell Function.
J. Wedel,^1,2 M. Stack,^1,2 T. Seto,^1,2 M. Sheehan,^1,2 K. Liu,^1,2 E. Flynn,^1,2 D. Briscoe.^1,2
¹Transplant Research Program, Boston Children's Hospital, Boston; ²Department of Pediatrics, Harvard Medical School, Boston
TSAd is an SH2 domain containing intracellular adapter molecule that functions to elicit T cell receptor-mediated signals and cytokine production. TSAd knockout (KO) T cells…
2017 American Transplant Congress
mRNA Biomarkers in Renal Allograft Protocol Biopsies Detected by the Nanostring Platform Predict Tolerance in Non-Human Primates.
M. Matsunami,¹ T. Oura,¹ I. Rosales,² R.-N. Smith,² B. Adam,³ M. Mengel,³ A. Cosimi,¹ R. Colvin,² T. Kawai.¹
¹Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ³Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
Background. Renal allograft tolerance has been achieved in some but not all MHC mismatched kidneys in non-human primates (NHPs) and humans after induction of transient…
2017 American Transplant Congress
Differential Effect of Antibody Removal on ABO Blood Group Type Chain Specific Antibodies Over Time.
A. Bentall,¹ M. Jeyakanthan,² J. Pearcey,² B. Motyka,² C. Cairo,³ T. Lowary,³ J. Buriak,⁴ L. West,² S. Ball.¹
¹Department of Nephrology, University Hospital Birmingham, Birmingham, United Kingdom; ²Departs of Pediatrics, Surgery and Immunology, University of Alberta, Alberta Transplant Institute, Edmonton, Canada; ³Alberta Glycomics Centre, Univ of Alberta, Dept of Chemistry, Edmonton, Canada; ⁴Dept of Chemistry, National Institute of Nanotechnology, Edmonton, Canada
Introduction: The trisaccharide epitope defines A&B blood group antigens where antibody binds to subtype chains (I-VI), but only subtype II is expressed on cardiac vascular…
2017 American Transplant Congress
Liver Targeted Expression of a Single Allogeneic MHC I Molecule Promotes Tolerance to Pancreatic Islet Allograft by Inducing Specific CD8+ Regulatory T Cells in Mice.
V. Le Guen,^1,2 J.-P. Judor,^1,2 V. Gauttier,^1,2 N. Ferry,³ J.-P. Soulillou,^1,2 S. Brouard,^1,2 S. Conchon.^1,2
¹Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Nantes, France; ²Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France; ³Département de Thérapie Cellulaire, CHU Saint Louis, Paris, France
A. Induction of donor-specific immune tolerance is a good alternative to chronic life-long immunosuppression for transplant patients. Donor major histocompatibility complex (MHC) molecules represent the…
2017 American Transplant Congress
Alloimmune Quiescence in Recipients with Long-Term Surviving Kidney Grafts.
K. Brown,¹ W. Baldwin,¹ E. Poggio,² W. Braun,² R. Fairchild.¹
¹Department of Immunology, Cleveland Clinic, Cleveland, OH; ²Nephrology and Glickman Urological Institue, Cleveland Clinic, Cleveland, OH
Recent studies of tolerant kidney transplant patients have identified increased numbers of circulating B cells expressing an immature/transitional phenotype (IgD+CD27-/IgD+CD27-CD24+CD38+). Similar frequencies of these immature/transitional…
2017 American Transplant Congress
The Gut Microbiota Regulates Murine Cardiac Transplant Outcome.
Y. Xiong, C. Brinkman, L. Hittle, W. Fricke, E. Mongodin, J. Bromberg.
UMB, Baltimore
Background: Gut microbiota regulates systemic immunity and can activate pro- or anti-inflammatory pathways. We hypothesized that the gut microbiota influences the survival of mismatched murine…
2017 American Transplant Congress
Maximizing the Potential of Treg-Based Therapies for Transplant Rejection via Computational Immune-Modeling: Effect of Dose, Timing, and Distribution.
G. Raimondi,¹ A. Arun,¹ O. Dorabiala,² J. Arciero.³
¹Plastic & Reconstructive Surgery, Johns Hopkins University, Baltimore; ²Mathematics, Pennsylvania State University, Philadelphia; ³Mathematical Sciences, Indiana University-Purdue University Indianapolis, Indianapolis
Purpose. Regulatory T cells (Treg), endogenous regulators of the immune system, have a significant therapeutic potential for prevention of transplant rejection. Experimental evidences however, indicate…
2017 American Transplant Congress
Validation of CYP4F11 as a Marker of Accommodation in Biopsies from Recipients of an ABO-Incompatible Renal Transplant.
K. Dominy,¹ M. Willicombe,³ T. Al Johani,² J. Galliford,³ A. McLean,³ T. Cook,³ C. Roufosse.³
¹Centre for Complement and Inflammation Research, Imperial College, London, United Kingdom; ²King Saud University, Riyadh, Saudi Arabia; ³Imperial College Healthcare NHS Trust, London, United Kingdom
Recipients of an ABO incompatible transplant have circulating anti-AB antibodies, A and/or B antigens expressed on endothelium and usually C4d deposition on the endothelium, yet…
2017 American Transplant Congress
Blood Tfh Cells Exhibit Impaired B Cell Help in Operationally Tolerant Patients.
R. Danger,¹ A. Chenouard,¹ M. Chesneau,¹ S. Castagnet,² P. Guérif,¹ N. Degauque,¹ M. Giral,¹ S. Brouard.¹
¹Inserm UMR 1064, Nantes University Hospital, Nantes, France; ²HLA Laboratory, Etablissement Français du Sang, Nantes, France
Introduction: Operationally tolerant (TOL) patients display a defect of B cell differentiation, with a deficiency in circulating plasma cells secreting antibodies, which could partly contribute…
2017 American Transplant Congress
Induction of Tolerance to Renal Allografts in Non Human Primates by Concomitant Donor-Matched Vascularized Osteomyocutaneous Allotransplantation.
F. Zhong,¹ G. Zhao,² Y. Wang,³ J. Jiang,³ Y. Wang,¹ S. Ye,¹ S. Tao,¹ L. Cai,¹ X. Wang,¹ Q. Ye,¹ G. Chen,² X. Zheng.¹
¹Center for Transplantation Medicine, Wuhan University Zhongnan Hospital, Wuhan, Hubei, China; ²Transplantation, Tongji Hospital, Wuhan, Hubei, China; ³Surgery, Shanghai Dongfan Hospital, Shanghai, China
Introduction: We hypothesized that hematopoietic stem cell (HSC) niches in bone marrow of vascularized osteomyocutaneous allografts (VOMA) will facilitate mixed chimerism (MC) and tolerance to…