Articles tagged "Tolerance"

2017 American Transplant Congress
Vital Role of the CoREST Complex as a Master Regulator of Foxp3+ T-Regulatory Cell Gene Expression and Suppressive Function.
L. Wang,¹ A. Samanta,¹ M. Levine,¹ U. Beier,¹ R. Han,¹ J. Kalin,² E. Holson,³ P. Cole,² W. Hancock.¹
¹Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; ²Johns Hopkins University, Baltimore, MD; ³Broad Institute, Cambridge, MA
While the Foxp3 promoter and its three associated conserved non-coding sequence (CNS)/enhancer regions have received much attention, literally nothing is known of the contribution of…
2017 American Transplant Congress
Type-1 Interferon Impairs the Immunoregulatory Activity of IL-10: A Mechanism in the Abrogation of Transplant Tolerance.
M. Iglesias, A. Arun, B. Lam, W. Lee, G. Raimondi, G. Brandacher.
Plastic Surgery, Johns Hopkins University. School of Medicine, Baltimore, MD
PurposeA growing body of experimental evidence shows that engagement of toll like receptors (TLR) can abrogate or revert the tolerogenic effect of “costimulation blockade” in…
2017 American Transplant Congress
Operational Tolerance in Intestinal Transplantation: A Proven Possibility.
B. Houlihan,¹ P. Cha,^1,2 C. Cosentino,^1,2 J. Kaiser,^1,2 A. Shukla,¹ J. Hawksworth,^1,2 C. Matsumoto,¹ T. Fishbein,¹ A. Kroemer.¹
¹Transplant Department, Medstar Georgetown University Hospital, Washington, DC; ²Surgery, Walter Reed National Military Medical Center, Bethesda, MD
A The purpose of this study is to immunologically characterize the first operationally tolerant intestinal transplant (ITx) patient known to date.B Flow cytometry and rtPCR…
2017 American Transplant Congress
Liver Transplantation Tolerance Using Outbred Mice.
M. Morita,¹ C. Miller,² J. Fung,³ L. Lu,^1,2 S. Qian.^1,2
¹Immunology, Cleveland Clinic, Cleveland, OH; ²General Surgery, Cleveland Clinic, Cleveland, OH; ³University of Michigan, Chicago, MI
Success of organ transplantation currently depends on life-time immunosuppression, resulting in severe side effects. Induction of donor specific tolerance is ideal, which actually spontaneously occurs…
2017 American Transplant Congress
A Molecular Signature Characterized by Dominance of Negative Regulation over Cytotoxic Effectors in Tolerant Kidney Allograft Recipients.
J. Lee,¹ J. Leventhal,² C. Li,¹ A. Katapodis,³ S. Ildstad,⁴ M. Suthanthiran.¹
¹Medicine, Weill Cornell, NY, NY; ²Surgery, Northwestern Medicine, Chicago, IL; ³Novartis, Basel, Switzerland; ⁴Regenerex, Louisville, KY
Introduction. Development of tolerance biomarkers is important for interrogating the in-vivo immune status of patients entered in clinical trials of tolerance.Methods. To determine the feasibility…
2017 American Transplant Congress
Prominence of Graft-Infiltrating PD-L1^hi Cross-Dressed Dendritic Cells in Mouse Liver Transplant Tolerance.
Y. Ono, A. Perez Gutierrez, S. Yokota, O. Yoshida, T. Nakao, G. Camirand, D. Geller, A. Thomson.
Surgery, University of Pittsburgh, Pittsburgh, PA
Background: The mechanism underlying spontaneous liver allograft tolerance remains unclear. Given recent reports on the key role of recipient mouse dendritic cells (DCs) in host…
2017 American Transplant Congress
Differences in Kinetics of IFN-y Production Between Endogenous and Allotransplant-Induced Memory T Cells.
B. Gonzalez-Nolasco, J. Marino, W. Orent, G. Benichou.
Center for Transplantation Sciences, Massachusetts General Hospital / Harvard Medical School, Boston, MA
Background:CD8+ memory T cells produce IFN-g in a faster and stronger fashion than their naïve counterparts after allorecognition. Unmanipulated mice possess a proportion of endogenous…
2017 American Transplant Congress
A-Antigen (Ag)-Specific Tolerance Following A-Ag Administration to Infant Mice.
B. Motyka,¹ Y. Wang,¹ B. Lamarche,¹ I. Adam,¹ J. Pearcey,¹ K. Tao,¹ C. Cairo,² P. Cowan,³ L. West.¹
¹Dept Pediatrics, Alberta Transplant Institute, Canadian National Transplant Research Program, University of Alberta, Edmonton, Canada; ²Dept Chemistry, Alberta Glycomics Centre, University of Alberta, Edmonton, Canada; ³Immunology Research Centre, St Vincent's Hospital, University of Melbourne, Melbourne, Australia
Purpose: In contrast to adults, ABO-incompatible heart transplantation (ABOi HTx) can safely be performed in infants due to absent/low levels of anti-A/B antibodies (Ab). Tolerance…
2017 American Transplant Congress
Exosomes Containing IL35 Are Secreted by Donor-Specific Regulatory T Cells and Cause Linked-Suppression.
Y. Tomita,¹ W. Bracamonte-Baran,¹ E. Jankowska-Gan,¹ Q. Zhang,² D. Vignali,² W. Burlingham.¹
¹Surgery, Transplant Division, University of Wisconsin-Madison, Madison, WI; ²Immunology, University of Pittsburgh, Pittsburgh
Introduction: We previously reported that donor specific splenocytes transfusion (DST) plus anti-CD40L costimulatory blockade treatment causes allo-specific regulation approximately 5 weeks after the tolerization. The…
2017 American Transplant Congress
Dominant Role of Clonal Deletion in Achieving Immune Tolerance After Unrelated Cord Blood Transplantation.
P. Szabolcs,^1,2 X. Chen,¹ M. Hill.¹
¹BMT and Cell Therapy, Children Hospital of Pittsburgh UPMC, Pittsburgh, PA; ²Immunology, University of Pittsburgh, Pittsburgh, PA
The mechanism of immune tolerance after successful hematopoietic stem cell transplantation is not fully understood. Both central (clonal deletion) and peripheral (anergy, Treg, Tr1) mechanisms…