Articles tagged "Tolerance"

2018 American Transplant Congress
Thymus Co-Transplantation Promotes Donor-Specific Tolerance in Allogeneic Heart Transplantation
J. Kwun,¹ J. Li,² C. Rouse,³ J. Park,¹ A. Kirk,¹ L. Markert.²
¹Surgery, Duke University, Durham, NC; ²Pediatrics, Duke University, Durham, NC; ³Laboratory Animal Resources, Duke University, Durham, NC.
Background: Allogeneic thymus has been investigated to achieve donor-specific tolerance in organ transplantation. Often thymus co-transplantation induces long-term graft survival in immunodeficient and total lymphoid…
2018 American Transplant Congress
Low Intensity Conditioning Protocol for Inducing Chimerism-Based Tolerance in Non-Obese Diabetic Mice
A. Chhabra, Y. Huang, H. Xu, A. Merchak, S. Ildstad.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
Type 1 diabetes is the most common chronic disease affecting children. Islet cell or pancreas transplantation offer the most physiologic approach to glucose homostasis. However…
2018 American Transplant Congress
Assessment of Donor Specific Anti-HLA Antibodies throughout SLK Transplantation
P. Jindra, M. Kueht, S. Gray, D. Giang, M. Cusick, A. Rana, B. Murthy, W. Etheridge, J. Goss, R. Kerman.
Division of Abdominal Transplantation and Hepatobiliary Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX.
Simultaneous Liver-Kidney transplantation provides a mechanism to protect the transplanted kidney from recognition by the recipient's immune response compared to solitary kidney transplant alone. High…
2018 American Transplant Congress
CD4⁺ T Cells Are Key Barriers to Tolerance Resistance to Islet Allografts in Autoimmune NOD Mice
A. Burrack,¹ K. Beard,² M. Coulombe,² R. Gill.²
¹Microbiology, Immunology, and Cancer Biology, University of Minnesota, Minneapolis, MN; ²Surgery, University of Colorado Denver, Aurora, CO.
Pancreatic islet allografts are effective for restoring euglycemia in type 1 diabetics (T1D) but are vulnerable to rejection by autoreactive (islet-specific) and/or conventional alloreactive T…
2018 American Transplant Congress
Long-Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients
J. Leventhal,¹ J. Galvin,¹ J. Mathew,¹ L. Gallon,¹ D. Stare,¹ K. Kurtenbach,¹ K. Ravindra,³ M. Horwitz,³ J. Miller,¹ M. Abecassis,¹ S. Ildstad.²
¹Surgery, Northwestern U, Chicago; ²U of Louisville, Louisville; ³Duke U, Durham.
37 pts have been transplanted in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts (KTx). The protocol is based…
2018 American Transplant Congress
Tomotherapy and Donor Hematopoietic Cells for Tolerance to Kidney Transplants in Rhesus Macaques
D. Kaufman,¹ L. Haynes,¹ P. Hematti,¹ W. Burlingham,¹ L. Forest,² J. Post,¹ R. Redfield,¹ L. Fernandez,¹ A. D'Alessandro,¹ J. Haynes,¹ K. Jensen,³ S. Strober.³
¹Surgery, University of Wisconsin School of Medicine, Madison, WI; ²Surgical Sciences, University of Wisconsin School of Vet Med, Madison, WI; ³Medicine, Stanford University Medical School, Palo Alto, CA.
The goal of this project was to develop a tolerance induction protocol for MHC 1-haplotype mismatched kidney transplants (txs) in a rhesus macaque model. The…
2018 American Transplant Congress
Renal Allograft Molecular Pathways Associated with Tolerance Induction in Renal Transplantation
L. Gallon,¹ J. Mathew,¹ S. Bontha,² C. Dumur,² P. Dalal,¹ L. Nadimpalli,¹ D. Maluf,² A. Shetty,¹ S. Ildstad,³ J. Leventhal,¹ V. Mas.²
¹Department of Medicine-Nephrology, Northwestern University, Chicago, IL; ²Department of Surgery, University of Virginia, Charlottesville, VA; ³Departments of Surgery, Physiology and Immunology, University of Louisville, Louisville, KY.
Background: Chronic exposure to immunosuppressive agents for organ transplant results in graft nephrotoxicity, infections and malignancies We have established durable immune tolerance in mismatched related…
2018 American Transplant Congress
Association between Everolimus Trough Levels, Onset of Related Adverse Events, and Treatment Discontinuation after Liver Transplantation: 24-Month Results from the H2304 Study
J. Fung,¹ F. Saliba,¹ H. Schlitt,¹ G. Junge,² K. McCague,³ D. Patel,³ M. Charlton.¹
¹H2304 Study Group, Chicago; ²Novartis Pharma AG, Basel, Switzerland; ³Novartis Pharmaceuticals Corporation, East Hanover.
Purpose: Evaluation of mammalian target of rapamycin inhibitor (mTORi)-related adverse events (AEs) and drug trough levels (C0) at onset may aid their management in liver…
2018 American Transplant Congress
Enhancement of Muscle Regeneration and Function via Transplantation of Human Dystrophin Expressing Chimeric Cells as a Novel Myoblast Stem-Cell Based Therapy
M. Siemionow,¹ J. Cwykiel,¹ E. Marchese,¹ G. Rafidi,¹ K. Futoma,¹ A. Heydemann,² J. Garcia-Martinez,² E. Szilagyi.¹
¹Orthopaedics, University of Illinois at Chicago, Chicago; ²Physiology and Biophysics, University of Illinois at Chicago, Chicago.
PURPOSE: Allogeneic myogenic stem cell transplantation aims to restore muscle tissue after traumatic loss or to treat muscular dystrophies. Limited engraftment due to allogeneic rejection…
2017 American Transplant Congress
Potential Mechanism Involving Regulatory T Cells in Induction of Tolerance in Mouse Vascularized Composite Allotransplantation Under Combined Costimulation Blockade.
M. Anggelia,^1,2 Y.-Y. Huang,³ W.-Y. Chuang,⁴ H.-Y. Cheng,¹ G. Brandacher,⁵ F.-C. Wei,^1,2 C.-H. Lin.^1,2
¹PRS, Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ²Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan; ³Nephrology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁴Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁵Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD
Background: Role of Regulatory T cells in vascularized composite allotransplantation (VCA) remains to be elucidated. In this study, we investigate potential mechanism involved in Tregs…