2022 American Transplant Congress
Tolerance of Allogeneic Kidneys with Durable (>200 Days) Multilineage Chimerism and Bone Marrow Engraftment in Cynomolgus Macaques
*Purpose: We have previously reported that a regimen including anti-CD3 immunotoxin, 45 days of cyclosporine, and pre-transplant total body irradiation (TBI) promoted tolerance of kidney…2022 American Transplant Congress
A Signature of Tolerance Which Identifies Subclinical Rejection-Free Patients at One Year After Kidney Transplantation
*Purpose: Spontaneous and rare cases of patients undergoing a functional renal transplant in the absence of immunosuppression represent a particular situation of immune tolerance. We…2022 American Transplant Congress
Single-Cell CyTOF Profiling of Pediatric Immune Responses to Organ Transplantation Reveals a Novel Subpopulation of T Cells Significantly Correlating with Graft Health
1Stanford University, Palo Alto, CA, 2Rho, Durham, NC, 3National Institutes of Health, Bethesda, MD
*Purpose: Solid organ transplant is lifesaving for children with end-stage heart, liver, or kidney disease. Protection of the transplanted organ from rejection requires long-standing immunosuppression.…2022 American Transplant Congress
Chimeric Antigen Receptor Regulatory T Cells (CAR-Tregs) Provide Significantly Greater Modulation of Alloimmune Responses Than Alternative Alloantigen-Specific Treg Strategies
1King's College London, London, United Kingdom, 2Quell Therapeutics, London, United Kingdom
*Purpose: Conferring alloantigen-specificity to ex vivo expanded CD4+CD25+Foxp3+ Tregs increases their capacity to counteract effector alloimmune responses following adoptive transfer into transplant recipients. This has…2022 American Transplant Congress
Development of an M2 Macrophage Signature in Spontaneously Accepted Kidney Allografts
*Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) are spontaneously accepted. We have recently shown that novel regulatory Tertiary Lymphoid…2022 American Transplant Congress
Absence of DAP12 Expression by Donor Liver-Derived Dendritic Cells Enhances Their Contact with T Cells in Host Secondary Lymphoid Tissue: Implications for Abrogation of MHC-mismatched Liver Transplant Tolerance in Mice
University of Pittsburgh, Pittsburgh, PA
*Purpose: Multiphoton intravital microscopy is a high-resolution, real-time, fluorescence imaging technique that enables study of interactions between cells in their native, 3-dimensional environment including organ…2022 American Transplant Congress
The Impact of Early Graft Infiltrating TCF-1LowPD-1HighCD8+ T Cells in Delayed Fc Nonbinding Anti-CD3 Antibody Protocol in the Sensitized Mouse Model
*Purpose: Fc nonbinding anti(a)-CD3 antibody has a unique effect that delayed treatment protocol induces a transplant tolerance. Delayed protocol allows early graft infiltrating cells which…2022 American Transplant Congress
T Cell Overexpression of PD-1 Increases Treg Suppressive Function via an ICOS-Dependent Mechanism
*Purpose: The PD-1: PD-L1 signaling has inhibitory properties and is a potential therapeutic target in transplantation. We have previously demonstrated that overexpression of PD-1 on…2022 American Transplant Congress
Single-Cell Multiomics Defines Tolerogenic Extrathymic Aire-Expressing Cells
*Purpose: The Autoimmune Regulator (Aire) gene, essential for central tolerance through its regulation of tissue-specific antigens in medullary thymic epithelial cells, is also expressed in…2022 American Transplant Congress
Alloreactive Regulatory T Cells Release Distinct Subpopulations of Extracellular Vesicles Bearing Immune Regulatory Proteins and the TCR/CD3 Complex Under Antigen Specific Stimulation
Brigham and Women's Hospital, Boston, MA
*Purpose: Extracellular vesicles (EVs) are vital mediators of intercellular communication, playing an important role in the immune synapse and the T cell response. However, regulatory…
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