Articles tagged "Tolerance"

2018 American Transplant Congress
Increased Expression of CEACAM1 is Cytoprotective during Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation
R. Sosa,¹ J. Nevarez-Mejia,¹ M. Rossetti,¹ A. Zarrinpar,² F. Kaldas,² C. Lassman,¹ B. Naini,¹ N. Datta,² R. Busuttil,² D. Gjertson,¹ J. Kupiec-Weglinski,² E. Reed.¹
¹Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA; ²Surgery, University of California, Los Angeles, Los Angeles, CA.
Background T cell exhaustion has recently been proposed as an alternative mechanism to prevent memory development and tissue damage arising during ischemia-reperfusion injury (IRI) in…
2018 American Transplant Congress
C5aR Regulates Myeloid Derived Suppressor Cells (MDSCs) in Transplantation
I. Llaudo, J. Ochando, P. Heeger.
Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Prolonged survival of anti-CD154-(MR1)-treated murine heart transplant recipients is dependent on regulatory T cells (Treg) and MDSC. Based on studies in the tumor literature suggesting…
2018 American Transplant Congress
Relationship between Mixed Chimerism and Acceptance of HLA-Matched and Mismatched Kidney Transplants after Withdrawal of Immunosuppressive Drugs
J. Scandling, S. Busque, R. Lowsky, J. Shizuru, K. Jensen, A. Shori, E. Engleman, E. Meyer, R. Hoppe, S. Strober.
Stanford University, Stanford, CA.
Classical studies in cattle and rodents showed that mixed chimerism (MXC) established in fetuses and neonates was permanent, linked to immune tolerance and graft acceptance…
2018 American Transplant Congress
Type-1 Interferon Impairs the Immunoregulatory Activity of IL-10: Understanding the Mechanisms of Abrogation of Transplant Tolerance
M. Iglesias, A. Arun, M. Chicco, B. Lam, V. Ivanova, W. Lee, G. Brandacher, G. Raimondi.
Plastic Surgery, Johns Hopkins UIniversity, Baltimore, MD.
A growing body of evidence shows that induction of long term transplant survival by costimulation blockade (CoB) regimens is impaired by inflammatory responses (e.g. engagement…
2018 American Transplant Congress
Thymus Co-Transplantation Promotes Donor-Specific Tolerance in Allogeneic Heart Transplantation
J. Kwun,¹ J. Li,² C. Rouse,³ J. Park,¹ A. Kirk,¹ L. Markert.²
¹Surgery, Duke University, Durham, NC; ²Pediatrics, Duke University, Durham, NC; ³Laboratory Animal Resources, Duke University, Durham, NC.
Background: Allogeneic thymus has been investigated to achieve donor-specific tolerance in organ transplantation. Often thymus co-transplantation induces long-term graft survival in immunodeficient and total lymphoid…
2018 American Transplant Congress
Low Intensity Conditioning Protocol for Inducing Chimerism-Based Tolerance in Non-Obese Diabetic Mice
A. Chhabra, Y. Huang, H. Xu, A. Merchak, S. Ildstad.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
Type 1 diabetes is the most common chronic disease affecting children. Islet cell or pancreas transplantation offer the most physiologic approach to glucose homostasis. However…
2018 American Transplant Congress
Assessment of Donor Specific Anti-HLA Antibodies throughout SLK Transplantation
P. Jindra, M. Kueht, S. Gray, D. Giang, M. Cusick, A. Rana, B. Murthy, W. Etheridge, J. Goss, R. Kerman.
Division of Abdominal Transplantation and Hepatobiliary Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX.
Simultaneous Liver-Kidney transplantation provides a mechanism to protect the transplanted kidney from recognition by the recipient's immune response compared to solitary kidney transplant alone. High…
2018 American Transplant Congress
CD4⁺ T Cells Are Key Barriers to Tolerance Resistance to Islet Allografts in Autoimmune NOD Mice
A. Burrack,¹ K. Beard,² M. Coulombe,² R. Gill.²
¹Microbiology, Immunology, and Cancer Biology, University of Minnesota, Minneapolis, MN; ²Surgery, University of Colorado Denver, Aurora, CO.
Pancreatic islet allografts are effective for restoring euglycemia in type 1 diabetics (T1D) but are vulnerable to rejection by autoreactive (islet-specific) and/or conventional alloreactive T…
2018 American Transplant Congress
Long-Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients
J. Leventhal,¹ J. Galvin,¹ J. Mathew,¹ L. Gallon,¹ D. Stare,¹ K. Kurtenbach,¹ K. Ravindra,³ M. Horwitz,³ J. Miller,¹ M. Abecassis,¹ S. Ildstad.²
¹Surgery, Northwestern U, Chicago; ²U of Louisville, Louisville; ³Duke U, Durham.
37 pts have been transplanted in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts (KTx). The protocol is based…
2018 American Transplant Congress
Tomotherapy and Donor Hematopoietic Cells for Tolerance to Kidney Transplants in Rhesus Macaques
D. Kaufman,¹ L. Haynes,¹ P. Hematti,¹ W. Burlingham,¹ L. Forest,² J. Post,¹ R. Redfield,¹ L. Fernandez,¹ A. D'Alessandro,¹ J. Haynes,¹ K. Jensen,³ S. Strober.³
¹Surgery, University of Wisconsin School of Medicine, Madison, WI; ²Surgical Sciences, University of Wisconsin School of Vet Med, Madison, WI; ³Medicine, Stanford University Medical School, Palo Alto, CA.
The goal of this project was to develop a tolerance induction protocol for MHC 1-haplotype mismatched kidney transplants (txs) in a rhesus macaque model. The…