Articles tagged "Tolerance"

2018 American Transplant Congress
A Phase-I Clinical Trial of Donor-Derived MIC Cell Infusion for the Induction of Donor-Specific Hyporesponsiveness after Living Donor Kidney Transplantation (TOL-1 Study)
C. Morath,¹ A. Schmitt,² C. Kleist,³ V. Daniel,³ G. Opelz,³ C. Süsal,³ F. Fälble,¹ C. Sommerer,¹ L. Wang,² M. Zeier,¹ M. Schmitt,² M. Schaier,¹ P. Terness.³
¹Nephrology, University of Heidelberg, Heidelberg, Germany; ²Hematology, University of Heidelberg, Heidelberg, Germany; ³Transplant Immunology, University of Heidelberg, Heidelberg, Germany.
MIC cells are donor-derived monocytes that gain immunosuppressive properties after incubation with the proliferation inhibitor mitomycin C.PBMCs were harvested from living donors by leukapheresis and…
2018 American Transplant Congress
A Novel Conditioning Approach to Establish Chimerism Using Manipulation of JAK-STAT Pathways
H. Xu, A. Merchak, L. Kahn, A. Chhabra, Y. Wen, Y. Huang, S. Ildstad.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
Hematopoietic chimerism establishes donor-specific tolerance to solid organ allografts. Targeting recipient immune cells (T, NK cells and macrophages) can effectively reduce the dose of total…
2018 American Transplant Congress
Long Noncoding RNA NEAT1 Induces Tolerogenic Dendritic Cells in Heart Transplantation
J. Wu,^1,2 Y. Zheng,^1,2 S. Li,^1,2 M. Zhang,^1,2 H. Zhang,^1,2 X. Zheng,^1,2 Y. Sun,^1,2 B. Yu.^1,2
¹Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China; ²The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, Heilongjiang, China.
Purpose: Tolerogenic dendritic cells have been gaining interest as an efficient means of promoting antigen-specific tolerance in organ transplantation. Long noncoding RNA NEAT1 plays an…
2018 American Transplant Congress
The LncRNA MALAT1 Induces Tolerogenic DCs and Antigen Specific Tregs Subsequently Mediating Cardiac Allograft Tolerance in Mice via MiR-155/DC-SIGN/IL10 Axis
M. Zhang,^1,2 J. Wu,^1,2 H. Zhang,^1,2 M. Liu,^1,2 Y. Zheng,^1,2 X. Jin,^1,2 S. Li,^1,2 Q. Zhao,^1,2 X. Liu,^1,2 Y. Sun,^1,2 B. Yu.^1,2
¹Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China; ²The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, Heilongjiang, China.
Background: Tolerogenic dendritic cells(DCs) by shaping T cells immunity and inducing Tregs play critical roles in the induction of allograft tolerance in transplantation. Long noncoding…
2018 American Transplant Congress
Tacrolimus-Based Maintenance Immunosuppression Decreases the Number of Peripheral Blood Transitional B Cells in Nonhuman Primates
J. Paster, K. Pruner, M. Hanekamp, J. O., W. Sommer, K. Robins, A. Bean, G. Benichou, J. Madsen.
Center for Transplantation Sciences, Mass General Hospital, Boston, MA.
IntroductionElevated frequencies of transitional B cells have been reported in patients tolerant of renal allografts, as defined by stable graft function after withdrawal of immunosuppression…
2018 American Transplant Congress
The Mark of Zorro: IL35-Coated Exosomes Cross-Dress and Exhaust Recipient T & B Cells during Transplant Tolerance
W. Burlingham,¹ J. Sullivan,¹ D. Lema,¹ Y. Tomita,² Y. Zhou,¹ D. Vignali.³
¹Surgery, University of Wisconsin, Madison, WI; ²Surgery, Tokyo Women's Hospital, Tokyo, Japan; ³Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA.
The folk-hero "Zorro" left his mark on by a sword-slashed "Z". In transplant recipients, rare Tregs also leave a mark on their conventional T &…
2018 American Transplant Congress
RNA Expression Profiling of Renal Allografts in the Cynomolgus Monkey Identifies Tolerance
R. Smith,¹ M. Matsunami,³ B. Adam,² A. Rosales,¹ T. Oura,³ A. Cosimi,³ T. Kawai,³ M. Mengel,² R. Colvin.¹
¹Pathology, Massachusetts General Hospital, Boston, MA; ²Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ³Department of Surgery, Massachusetts General Hospital, Boston, MA.
IntroductionTolerance induction is a long standing clinical goal. However, identification remains elusive. Here we profile intra-renal allograft RNA expression in a mixed chimerism renal allograft…
2018 American Transplant Congress
Human CD8⁺CD28^– Ts Cells Expanded by Common Gamma Chain (γc) Cytokines Keep Steady Allospecific Suppressive Capacity In Vivo
G. Liu,¹ F. Feng,¹ P. Zhu,¹ J. Liu,² Y. Liu,¹ Y. Yu.²
¹Department of Immunology, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong, China; ²Department of Urology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.
Background: CD8+CD28- T suppressor (Ts) cells were recently reported to play a critical role in transplant tolerance, harnessing the potential for clinical use in transplantation.…
2018 American Transplant Congress
Heart En Bloc Thymus Cotransplantation in NHPs Controls Cellular but Not Humoral Alloreactivity
W. Sommer, J. O., K. Pruner, J. Paster, M. Hanekamp, A. Dehnadi, I. Rosales, R. Smith, R. Colvin, G. Benichou, J. Allan, J. Madsen.
Massachusetts General Hospital, Boston.
Background: We have achieved tolerance of cardiac allografts in Cynomolgus monkeys for the first time by using a mixed chimerism-based conditioning protocol and by co-transplanting…
2018 American Transplant Congress
Loss of HIF-1α in CD4 T Cell Improve Outcome of Mouse Vascularized Osteomyocutaneous Allotransplantation under Costimulation Blockade
C-.H. Lin,^1,2 M. Anggelia,^1,2 H. Yang,³ W. Chuang,⁴ H. Cheng,¹ F-.C. Wei,^1,2 G. Brandacher.⁵
¹PRS, Center for VCA, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ²Chang Gung Medical College and Chang Gung University, Taoyuan, Taiwan; ³Nephrology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁴Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ⁵PRS, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: Allograft survival depends on the balance of effector T cells (Teff) and regulatory T cells (Tregs). Previous study suggested that the balance is controlled…