Articles tagged "Tolerance"

2019 American Transplant Congress
Endothelial Cell Replacement – A Closer Step to Personalized, Tissue-Engineered Transplants
S. Cohen, S. Partouche, M. Gurevich, V. Mezhybovsky, V. Tennak, S. Eisner, E. Nesher, E. Mor
Rabin Medical Center, Petah-Tiqwa, Israel
*Purpose: Whole organ perfusion decellularization has been proposed as a promising method for the generation of non-immunogenic organs from allogeneic or xenogeneic donors. However, the…
2019 American Transplant Congress
Interruption of Notch Signaling via Blockade of Delta-Like Ligands 1 and 4 Prevents Co-Stimulation Blockade Resistant Allograft Rejection
A. Matar, Y. Dong, B. Lovasik, D. Mathews, A. Ghosh, C. Breeden, A. Stephenson, W. Kitchens, A. Adams
Surgery and Transplantation, Emory University, Atlanta, GA
*Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy with the advent of belatacept, a novel CTLA4-Ig fusion protein that blocks CD28-mediated T…
2019 American Transplant Congress
After 10 Years: The Results of HLA Mismatched Combined Kidney and Bone Marrow Transplantation for Renal Allograft Tolerance
T. Kawai¹, D. H. Sachs¹, T. Spitzer¹, N. Tolkoff-Rubin¹, R. B. Colvin¹, N. Elias¹, M. Sykes², A. Cosimi¹
¹Massachusetts General Hospital, Boston, MA, ²Columbia University, NYC, NY
*Purpose: Based on decades-long basic studies in animal models, we have applied combined kidney and donor bone marrow transplantation (CKBMT) for induction of allograft tolerance…
2019 American Transplant Congress
Rcor1 and Regulation of Foxp3+ T-Regulatory Cells In Vitro and In Vivo
Y. Xiong, L. Wang, R. Han, W. W. Hancock
Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: While Foxp3+ T-regulatory (Treg) cells are well established as central players in regulation of allograft acceptance and tolerance, the contributions of several types of…
2019 American Transplant Congress
T Cell-Intrinsic Dysfunction in Donor-Specific Transplantation Tolerance
C. M. McIntosh¹, M. L. Miller², Y. Wang¹, A. Chong³, M. Alegre¹
¹Department of Medicine, University of Chicago, Chicago, IL, ²Department of Immunology, University of Pittsburgh, Pittsburgh, PA, ³Department of Surgery, University of Chicago, Chicago, IL
*Purpose: Donor-specific tolerance offers many advantages over current lifelong non-specific immunosuppression strategies, but the mechanisms by which it may be durably maintained remain to be…
2019 American Transplant Congress
Microparticle Delivery to Lymph Nodes Induces Specific Suppression to Prolong Islet Survival
Y. Xiong¹, L. Tostanoski², C. Jewell³, J. Bromberg¹
¹Surgery, U. Maryland, Baltimore, MD, ²U.Maryland, Baltimore, MD, ³U. Maryland, College Park, MD
*Purpose: Microparticles (MP) loaded with peptide antigen plus other immune signals and delivered directly into lymph nodes (LN) can result in either proinflammatory or antiinflammatory…
2019 American Transplant Congress
Adipose Stem Cells Promote Composite Tissue Engraftment
N. Shockcor¹, B. Buckingham¹, W. Hassanein¹, D. Parsell¹, U. Dhru¹, B. Akinsiku², E. Elster², T. Davis², J. Gimble³, A. Nam¹, S. Bartlett¹, R. Barth¹
¹Surgery, University of Maryland, Baltimore, MD, ²Uniformed Services University of the Health Sciences, Bethesda, MD, ³LaCell LLC, New Orleans, LA
*Purpose: Adipose-derived stem cells (ASC) have increased levels of anti-inflammatory and immunoregulatory factors. Murine studies have shown stable macrochimerism and long-term full thickness skin graft…
2019 American Transplant Congress
Alloreactive B Cells in Transplant Tolerant Recipients Cannot Differentiate into Antibody-Secreting Cells but Can Suppress Donor-Specific IgG Production By Naïve B Cells
S. H. Khiew¹, J. Chen¹, D. Jain¹, Q. Wang¹, D. Yin¹, M. Alegre², A. S. Chong¹
¹Department of Surgery, Section of Transplant, University of Chicago, Chicago, IL, ²Department of Medicine, University of Chicago, Chicago, IL
*Purpose: Donor specific transplantation tolerance has long been the goal of clinical transplantation. Clinical observations suggest that donor-specific antibodies (DSA) are a major cause of…
2019 American Transplant Congress
High-Throughput Immune Synapse Detection as a Tool for the Measurement of T Cell Alloreactivity
S. Moshkelgosha, S. C. Juvet
UHN, Toronto, ON, Canada
*Purpose: Measurement of T cell alloreactivity may facilitate a more accurate prediction of graft outcome and the selection of patients for immunosuppression optimization. However, current…
2019 American Transplant Congress
Endogenous Erythropoietin is Required for Spontaneous Acceptance of Murine Renal Allografts
J. Horwitz, P. Cravedi, P. Heeger
Icahn School of Medicine at Mount Sinai, NY, NY
*Purpose: B6 recipients spontaneously accept MHC-disparate renal allografts from allogeneic DBA/2 x B6 (H-2d x H-2b) F1 donors via mechanisms that are in part regulatory…