ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Tolerance"

  • 2022 American Transplant Congress

    Trajectory Analysis Of Single Cell RNAseq Data Suggest Intrarenal Induction Of Tregs In Spontaneously Accepted Kidney Allografts

    M. Guinn1, E. S. Szuter1, T. Yokose1, J. Ge2, B. Kwon1, I. Rosales3, P. S. Russell1, A. Cuenca2, J. Madsen1, R. Colvin3, A. Alessandrini1

    1Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Surgery, Boston Children's Hospital, Boston, MA, 3Department of Pathology, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    *Purpose: Kidney allografts transplanted across certain mouse strain combinations (e.g. DBA/2 to B6) are spontaneously accepted independent of the recipient’s thymus, spleen, and lymph nodes.…
  • 2022 American Transplant Congress

    A FRET-Based Technique to Quantify Foxp3 Acetylation in TREG

    F. F. Gonzalez1, G. Vilanova2, M. Fribourg1

    1Icahn School of Medicine at Mount Sinai, New York, NY, 2Universitat Politècnica de Catalunya-BarcelonaTech, Barcelona, Spain

    *Purpose: Foxp3 acetylation is essential to TREG stability and function. Acetylation protects Foxp3 from degradation, and acetylated Foxp3 translocates to the nucleus to activate the…
  • 2022 American Transplant Congress

    Regulatory T Cell PopulationsMay be Associated with Transplant Outcomes

    H. Shin, S. Heo, Y. Kim, N. Lee, Y. Kim, Y. Jung, H. Rim

    Internal Medicine, Kosin University College of Medicine,Transplantation Research Institute,Gospel Hospital, Busan, Korea, Republic of

    *Purpose: The development of immunosuppressants has enabled remarkable progress in kidney transplantation (KT). However, current immunosuppressants cannot achieve induction of immune tolerance and their nonspecific…
  • 2022 American Transplant Congress

    Donor-Specific T Cell Senescence In Operationally Tolerant Liver Transplant Recipients

    K. Deng1, N. Tanimine2, C. Breeden3, B. Burrell3, G. Gaile3, K. Lee1, R. Matheson1, F. Qiang1, C. Rickert1, C. LeGuern1, J. Markmann1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Gastroenterological and Transplantation Surgery, Hiroshima University, Hiroshima, Japan, 3Immune Tolerance Network, Bethesda, MD

    *Purpose: Recent evidence indicates a correlation in liver transplant recipients between successful operational tolerance (OT) post immunosuppression withdrawal (ISW) with both recipient age and time…
  • 2022 American Transplant Congress

    Differing Gene Expression Profiles and Signaling Pathways Observed Between Alloreactive and Tolerant T Cells in a Recipient Following Bilateral Orthotopic Lung Transplant (BOLT) and Bone Marrow Transplant (BMT) from the Same Cadaveric UNOS Donor

    P. Szabolcs, E. Garchar, D. Rajasundaram, X. Chen

    UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA

    *Purpose: Primary immunodeficiency (PID) patients may develop pulmonary complications, and most are ineligible for either BOLT or BMT due to futility. A prospective trial in…
  • 2022 American Transplant Congress

    Characterization Of Gzmb+ Bregs Using Single Cell Rnaseq

    N. Sailliet, H. Le Mai, A. Dupuy, C. Fourgeux, M. Chesneau, J. Poschmann, R. Danger, S. Brouard

    CRT2I INSERM UMR1064, Nantes, France

    *Purpose: Granzyme B (GZMB)+ B cells are increased in blood from transplanted patients who tolerate a kidney graft without immunosuppressive treatment. We demonstrated that these…
  • 2022 American Transplant Congress

    Leveraging Car T Cells To Achieve Desensitization And Enable Transplantation

    V. BHOJ

    UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

    *Purpose: Pre-existing allo-antibodies (allo-Abs), that preclude transplant due to the risk of hyperacute rejection, lead to prolonged wait times and high mortality rates. Current desensitization…
  • 2022 American Transplant Congress

    Role of CD8+T Cells Exhaustion in Long Term Spontaneous Acceptance of Mouse Kidney Allograft

    J. Ge1, E. Szuter1, T. Yokose1, I. Rosales2, A. Cuenca3, P. Russell1, J. Madsen1, R. Colvin2, A. Alessandrini1

    1Center of Transplant Science, Massachusetts General Hospital, Boston, MA, 2Department of Pathology, Massachusetts General Hospital, Boston, MA, 3Department of Surgery, Boston Children's Hospital, Boston, MA

    *Purpose: CD8+ T cells exhaustion has been shown to promote chronic viral infection and tumor development, resulting from long term exposure to foreign antigen. We…
  • 2022 American Transplant Congress

    Long Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Kidney Transplant Recipients

    J. Leventhal1, J. Galvin2, J. Mathew3, L. Gallon3, D. Belshe4, M. Gibson4, K. Ravindra5, M. Horwitz6, S. Ildstad7

    1Feinberg School of Medicine, Northwestern University, Chicago, IL, 2University of Illinois Chicago, Chicago, IL, 3Northwestern University, Chicago, IL, 4Comprehensive Transplant Center, Northwestern University, Chicago, IL, 5Department of Surgery, Duke University Medical Center, Durham, NC, 6Adult Blood and Marrow Transplant Program, Duke University Medical Center, Durham, NC, 7Talaris Therapeutics Inc, Louisville, KY

    *Purpose: 37 subjects were transplanted in a phase 2 protocol based upon tolerogenic CD8+/TCR-facilitating cells (FCR001) to induce tolerance in recipients of living donor kidney…
  • 2022 American Transplant Congress

    Neuropilin-2 is a Novel Checkpoint Inhibitor That is Required for Long-Term Allograft Survival

    J. Wedel, S. Kong, K. Liu, N. Kochupurakkal, D. Bala, D. Bielenberg, H. Nakayama, D. M. Briscoe

    Boston Children's Hospital, Boston, MA

    *Purpose: We have previously reported that Neuropilin (NRP) 2-associated signaling events modulate PI3K/mTOR/Akt activity in several human cell lines. While intrinsic NRP1 activity has been…
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