2019 American Transplant Congress
Effects of Standard Drug Immunosuppression on Peripheral Transitional B Cells and Gene Expression in Non-Human Primates
*Purpose: Operationally tolerant renal transplant recipients exhibit an increased number of transitional B cells and an upregulation of selected B-cell associated genes in the periphery…2019 American Transplant Congress
Identification of Adult Liver Transplant Recipients Eligible to Participate in an Immunosuppression Withdrawal Trial Employing Non-Invasive Assessments of Allograft Status
*Purpose: Liver Immunosuppression Free Trial (LIFT) is a multicentre international prospective randomised controlled trial of biomarker-guided immunosuppression withdrawal in adult liver transplant recipients who meet…2019 American Transplant Congress
Immunologically Tolerant Liver Transplant Recipients Are Characterized by Donor-Specific Hypo Responsiveness of Circulating T-cells
*Purpose: Lifelong treatment with immunosuppressive drugs (IS) to prevent graft rejection in transplant recipients is accompanied by side effects. Some recipients are considered to be…2019 American Transplant Congress
Persistent Mixed Chimerism, Immune Reconstitution, and Tolerance in Recipients of HLA Matched Kidney and Hematopoietic Cell Transplants
Stanford University School of Medicine, Stanford, CA
*Purpose: We evaluated the immune reconstitution of recipients of HLA matched combined kidney and hematopoietic cell transplants after tolerance induction*Methods: Twenty nine recipients of living…2019 American Transplant Congress
High Fibre Diet Prevents Transplant-Associated Dysbiosis and Prevents Kidney Allograft Rejection
*Purpose: To investigate the impact of high fibre (HF) diet or dietary supplementation with the short chain fatty acid (SCFA) sodium acetate (SA) on kidney…2019 American Transplant Congress
Efficacy of Photobiomodulatory Therapy Combined with Short-Term Immunosuppressants Prolonged Allograft Survival in a Rodent Hind-Limb Model
*Purpose: Photobiomodulation has been applied for accelerating the skeletal muscle repair process. Our formal study demonstrated vitamin D could be involved in allograft survival and…2019 American Transplant Congress
A Novel Protocol to Produce Massive Amounts of Autologous Thymus-Derived Treg Cells (ThyTreg) to Be Employed as Cellular Therapy in Heart Transplanted Children: A New Paradigm for the Prevention of Graft Rejection
*Purpose: Immune allograft rejection remains the main obstacle to successful transplants. Although transfer of regulatory T cells (Treg) has acquired growing interest in achieving indefinite…2019 American Transplant Congress
Deficiency of the Transcription Factor Satb1 in T Cells Promotes Solid Organ Allograft Survival
*Purpose: Conventional CD4+ T cells are key effectors of allograft rejection and novel therapies limiting their response may hold promise in the context of organ…2019 American Transplant Congress
Use of Low Dose Interleukin-2 to Expand Regulatory T-cells and Facilitate the Complete Discontinuation of Immunosuppression in Human Liver Transplantation
*Purpose: Low dose interleukin-2 (LDIL-2) is capable of expanding endogenous CD4+CD25+FoxP3+ regulatory T-cells (Tregs) in vivo but its role in human solid organ transplantation is…2019 American Transplant Congress
Treg And Bone Marrow Infusion Promotes Survival Of Donor Kidney Grafted Months After Disappearance Of Mixed Chimerism
Columbia Center for Translational Immunology, Columbia University, New York City, NY
*Purpose: Transient mixed chimerism induced with non-myeloablative conditioning in monkeys and humans induces tolerance to about 70% of donor kidney grafts transplanted at the time…
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