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Articles tagged "Tolerance"

  • 2020 American Transplant Congress

    Eosinophils Maintain Lung Allograft Tolerance by Sequestering CD8+ T Cells in Bronchial Associated Lymphoid Tissue

    Z. Mei1, Y. Guo1, A. Hata1, A. Banerjee1, D. Li1, A. Manafi1, B. Mahgoub1, D. Kreisel2, A. Gelman2, A. S. Krupnick1

    1Department of Surgery, University of Virginia, Charlottesville, VA, 2Department of Surgery, Washington University in St. Louis, St. Louis, MO

    *Purpose: It has been recently described that eosinophils can facilitate immunosuppression-mediated acceptance of murine lung allografts. But the role of eosinophils in long term maintenance…
  • 2020 American Transplant Congress

    IL-10 Exposure Enhances IRAK-M Expression to Promote Endotoxin Tolerance and the T Cell Tolerogenic Potential of Liver Conventional DCs

    Y. Zheng, R. Nakano, A. Thomson

    Surgery, Starzl Transplantation Institute, Pittsburgh, PA

    *Purpose: Liver conventional myeloid (m)DC contribute to liver transplant tolerance. When freshly-isolated, they produce low levels of IL-12 but high levels of IL-10 compared with…
  • 2020 American Transplant Congress

    ABO Self-Tolerance in a Mouse Model: Evidence of Tolerance at B Cell but Not T Cell Level

    I. Adam, B. Motyka, K. Tao, L. West

    Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada

    *Purpose: We showed that human infants become tolerant to donor A/B-antigens (Ag) after ABO-incompatible heart transplantation (ABOi-HTx) by mechanisms not well-defined. To expand ABOi-HTx effectively…
  • 2020 American Transplant Congress

    Liver Plasmacytoid Dendritic Cells Express High Levels of DAP12, TREM2 and PD-L1 and Promote Effector T Cell Exhaustion and Augmented Treg Responses in Spontaneous Liver Transplant Tolerance

    R. Nakano, O. Yoshida, S. Kimura, D. Geller, A. Thomson

    University of Pittsburgh, Pittsburgh, PA

    *Purpose: The precise mechanisms of liver transplant tolerance are yet to be elucidated. Non-conventional plasmacytoid dendritic cells (pDCs) are thought to promote immune regulation, including…
  • 2020 American Transplant Congress

    The Gut Microbiota Stimulates Dendritic Cells for Immune Modulation

    V. Saxena, W. Piao, L. Hittle, L. Li, T. Simon, C. Palusckievicz, Y. Xiong, T. Zhang, M. Shirkey, E. F. Mongodin, J. S. Bromberg

    University of Maryland, Baltimore, Baltimore, MD

    *Purpose: The gut microbiota is a driving force in host immune regulation, and thus a potential target for intervention and drug development. We previously showed…
  • 2020 American Transplant Congress

    The Role of Antigen Presentation in B Regulatory Cell Function

    A. Cuenca1, N. Feeney2, K. Deng2, Q. Fu2, G. Huai2, C. Rickert2, K. Lee2, J. Markmann2

    1Boston Children's Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA

    *Purpose: B regulatory cells (B regs) represent a subset of B cells with non-canonical regulatory function. The majority of effort has been focused on the…
  • 2020 American Transplant Congress

    Neuropilin 2 is a Novel Coinhibitory Molecule That Suppresses Alloimmune Responses Following Transplantation

    J. Wedel, J. Lee, N. Kochupurakkal, E. Chernov, M. Poreddy, K. Liu, S. Kong, D. Bielenberg, H. Nakayama, D. M. Briscoe

    Boston Children's Hospital, Boston, MA

    *Purpose: We have previously reported that signaling via the transmembrane receptor neuropilin 2 (NRP2) regulates PI3K/mTOR/Akt activity in several human cell lines. Furthermore, it is…
  • 2020 American Transplant Congress

    Immune Checkpoint PD-L1 Pathway as an Effective Platform for Localized Immunomodulation to Attain Indefinite Allogeneic Islet Graft Survival

    L. Batra1, P. Shrestha1, H. Zhao1, K. B. Woodward1, M. Tan1, O. G. Nuno1, A. Togay1, M. M. Coronel2, A. J. Garcia2, H. Shirwan1, E. S. Yolcu1

    1Institute for Cellular Therapeutics and Department of Microbiology and Immunology, University of Louisville, Louisville, KY, 2Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA

    *Purpose: Allogenic islet transplantation is an effective therapeutic approach for the treatment of T1D. However, chronic immunosuppression to control rejection is a major limitation. The…
  • 2020 American Transplant Congress

    Preventing Allograft Rejection by Circrna FSCN1 Mediated Tolerogenic Dendritic Cells

    B. Wang, Q. Zhou, V. Veramkovich, A. Greasley, S. Li, X. Zheng

    Pathology, University of Western Ontario-LHSC, London, ON, Canada

    *Purpose: Induction of immune tolerance is a major challenge in heart transplants. There is no robust treatment with fewer side effects for preventing chronic rejection.…
  • 2020 American Transplant Congress

    HLA Cross-Dressing of Dendritic Cells by Maternal Exosomes is Associated with PD-L1 Expression in Newborns

    D. Lema1, S. Kanaan2, J. Nelson2, W. Burlingham1

    1University of Wisconsin-Madison, Madison, WI, 2Fred Hutchinson Cancer Research Center, Seattle, WA

    *Purpose: Recipients of a kidney transplant from a haplo-identical sibling had accelerated early acute rejection episodes, followed by improved long-term graft survival if the transplant…
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